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Article: Single-nucleotide polymorphisms based genetic risk score in the prediction of pancreatic cancer risk

TitleSingle-nucleotide polymorphisms based genetic risk score in the prediction of pancreatic cancer risk
Authors
KeywordsChinese population
Genetic risk score
Genome-wide association study
Pancreatic cancer
Single nucleotide polymorphisms
Issue Date2020
Citation
World Journal of Gastroenterology, 2020, v. 26, n. 22, p. 3076-3086 How to Cite?
AbstractBACKGROUND Disease-related single nucleotide polymorphisms (SNPs) based genetic risk score (GRS) has been proven to provide independent inherited risk other than family history in multiple cancer types. AIM To evaluate the potential of GRS in the prediction of pancreatic cancer risk. METHODS In this case-control study (254 cases and 1200 controls), we aimed to evaluate the association between GRS and pancreatic ductal adenocarcinoma (PDAC) risk in the Chinese population. The GRS was calculated based on the genotype information of 18 PDAC-related SNPs for each study subject (personal genotyping information of the SNPs) and was weighted by external odd ratios (ORs). RESULTS GRS was significantly different in cases and controls (1.96 ± 3.84 in PDACs vs 1.09 ± 0.94 in controls, P < 0.0001). Logistic regression revealed GRS to be associated with PDAC risk [OR = 1.23, 95% confidence interval (CI): 1.13-1.34, P < 0.0001]. GRS remained significantly associated with PDAC (OR = 1.36, 95%CI: 1.06-1.74, P = 0.015) after adjusting for age and sex. Further analysis revealed an association of increased risk for PDAC with higher GRS. Compared with low GRS (< 1.0), subjects with high GRS (2.0) were 99% more likely to have PDAC (OR: 1.99, 95%CI: 1.30-3.04, P = 0.002). Participants with intermediate GRS (1.0-1.9) were 39% more likely to have PDAC (OR: 1.39, 95%CI: 1.03-1.84, P = 0.031). A positive trend was observed (P trend = 0.0006). CONCLUSION GRS based on PDAC-associated SNPs could provide independent information on PDAC risk and may be used to predict a high risk PDAC population.
Persistent Identifierhttp://hdl.handle.net/10722/314406
ISSN
2023 Impact Factor: 4.3
2023 SCImago Journal Rankings: 1.063
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWang, Xiao Yi-
dc.contributor.authorChen, Hai Tao-
dc.contributor.authorNa, Rong-
dc.contributor.authorJiang, De Ke-
dc.contributor.authorLin, Xiao Ling-
dc.contributor.authorYang, Feng-
dc.contributor.authorJin, Chen-
dc.contributor.authorFu, De Liang-
dc.contributor.authorXu, Jian Feng-
dc.date.accessioned2022-07-20T12:03:58Z-
dc.date.available2022-07-20T12:03:58Z-
dc.date.issued2020-
dc.identifier.citationWorld Journal of Gastroenterology, 2020, v. 26, n. 22, p. 3076-3086-
dc.identifier.issn1007-9327-
dc.identifier.urihttp://hdl.handle.net/10722/314406-
dc.description.abstractBACKGROUND Disease-related single nucleotide polymorphisms (SNPs) based genetic risk score (GRS) has been proven to provide independent inherited risk other than family history in multiple cancer types. AIM To evaluate the potential of GRS in the prediction of pancreatic cancer risk. METHODS In this case-control study (254 cases and 1200 controls), we aimed to evaluate the association between GRS and pancreatic ductal adenocarcinoma (PDAC) risk in the Chinese population. The GRS was calculated based on the genotype information of 18 PDAC-related SNPs for each study subject (personal genotyping information of the SNPs) and was weighted by external odd ratios (ORs). RESULTS GRS was significantly different in cases and controls (1.96 ± 3.84 in PDACs vs 1.09 ± 0.94 in controls, P < 0.0001). Logistic regression revealed GRS to be associated with PDAC risk [OR = 1.23, 95% confidence interval (CI): 1.13-1.34, P < 0.0001]. GRS remained significantly associated with PDAC (OR = 1.36, 95%CI: 1.06-1.74, P = 0.015) after adjusting for age and sex. Further analysis revealed an association of increased risk for PDAC with higher GRS. Compared with low GRS (< 1.0), subjects with high GRS (2.0) were 99% more likely to have PDAC (OR: 1.99, 95%CI: 1.30-3.04, P = 0.002). Participants with intermediate GRS (1.0-1.9) were 39% more likely to have PDAC (OR: 1.39, 95%CI: 1.03-1.84, P = 0.031). A positive trend was observed (P trend = 0.0006). CONCLUSION GRS based on PDAC-associated SNPs could provide independent information on PDAC risk and may be used to predict a high risk PDAC population.-
dc.languageeng-
dc.relation.ispartofWorld Journal of Gastroenterology-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectChinese population-
dc.subjectGenetic risk score-
dc.subjectGenome-wide association study-
dc.subjectPancreatic cancer-
dc.subjectSingle nucleotide polymorphisms-
dc.titleSingle-nucleotide polymorphisms based genetic risk score in the prediction of pancreatic cancer risk-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3748/wjg.v26.i22.3076-
dc.identifier.pmid32587449-
dc.identifier.pmcidPMC7304113-
dc.identifier.scopuseid_2-s2.0-85087138161-
dc.identifier.volume26-
dc.identifier.issue22-
dc.identifier.spage3076-
dc.identifier.epage3086-
dc.identifier.eissn2219-2840-
dc.identifier.isiWOS:000556588200013-

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