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Article: Evaluation of PSA-age volume score in predicting prostate cancer in Chinese population

TitleEvaluation of PSA-age volume score in predicting prostate cancer in Chinese population
Authors
Keywordsage
China
prostate cancer
prostate-specific antigen
volume
Issue Date2018
Citation
Asian Journal of Andrology, 2018, v. 20, n. 4, p. 324-329 How to Cite?
AbstractThis study was performed to evaluate prostate-specific antigen-age volume (PSA-AV) scores in predicting prostate cancer (PCa) in a Chinese biopsy population. A total of 2355 men who underwent initial prostate biopsy from January 2006 to November 2015 in Huashan Hospital were recruited in the current study. The PSA-AV scores were calculated and assessed together with PSA and PSA density (PSAD) retrospectively. Among 2133 patients included in the analysis, 947 (44.4%) were diagnosed with PCa. The mean age, PSA, and positive rates of digital rectal examination result and transrectal ultrasound result were statistically higher in men diagnosed with PCa (all P < 0.05). The values of area under the receiver operating characteristic curves (AUCs) of PSAD and PSA-AV were 0.864 and 0.851, respectively, in predicting PCa in the entire population, both performed better than PSA (AUC = 0.805; P < 0.05). The superiority of PSAD and PSA-AV was more obvious in subgroup with PSA ranging from 2.0 ng ml -1 to 20.0 ng ml -1 . A PSA-AV score of 400 had a sensitivity and specificity of 93.7% and 40.0%, respectively. In conclusion, the PSA-AV score performed equally with PSAD and was better than PSA in predicting PCa. This indicated that PSA-AV score could be a useful tool for predicting PCa in Chinese population.
Persistent Identifierhttp://hdl.handle.net/10722/314422
ISSN
2023 Impact Factor: 3.0
2023 SCImago Journal Rankings: 0.689
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWu, Yi Shuo-
dc.contributor.authorWu, Xiao Bo-
dc.contributor.authorZhang, Ning-
dc.contributor.authorJiang, Guang Liang-
dc.contributor.authorYu, Yang-
dc.contributor.authorTong, Shi Jun-
dc.contributor.authorJiang, Hao Wen-
dc.contributor.authorMao, Shan Hua-
dc.contributor.authorNa, Rong-
dc.contributor.authorDing, Qiang-
dc.date.accessioned2022-07-20T12:04:01Z-
dc.date.available2022-07-20T12:04:01Z-
dc.date.issued2018-
dc.identifier.citationAsian Journal of Andrology, 2018, v. 20, n. 4, p. 324-329-
dc.identifier.issn1008-682X-
dc.identifier.urihttp://hdl.handle.net/10722/314422-
dc.description.abstractThis study was performed to evaluate prostate-specific antigen-age volume (PSA-AV) scores in predicting prostate cancer (PCa) in a Chinese biopsy population. A total of 2355 men who underwent initial prostate biopsy from January 2006 to November 2015 in Huashan Hospital were recruited in the current study. The PSA-AV scores were calculated and assessed together with PSA and PSA density (PSAD) retrospectively. Among 2133 patients included in the analysis, 947 (44.4%) were diagnosed with PCa. The mean age, PSA, and positive rates of digital rectal examination result and transrectal ultrasound result were statistically higher in men diagnosed with PCa (all P < 0.05). The values of area under the receiver operating characteristic curves (AUCs) of PSAD and PSA-AV were 0.864 and 0.851, respectively, in predicting PCa in the entire population, both performed better than PSA (AUC = 0.805; P < 0.05). The superiority of PSAD and PSA-AV was more obvious in subgroup with PSA ranging from 2.0 ng ml -1 to 20.0 ng ml -1 . A PSA-AV score of 400 had a sensitivity and specificity of 93.7% and 40.0%, respectively. In conclusion, the PSA-AV score performed equally with PSAD and was better than PSA in predicting PCa. This indicated that PSA-AV score could be a useful tool for predicting PCa in Chinese population.-
dc.languageeng-
dc.relation.ispartofAsian Journal of Andrology-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectage-
dc.subjectChina-
dc.subjectprostate cancer-
dc.subjectprostate-specific antigen-
dc.subjectvolume-
dc.titleEvaluation of PSA-age volume score in predicting prostate cancer in Chinese population-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.4103/aja.aja_81_17-
dc.identifier.pmid29405172-
dc.identifier.pmcidPMC6038173-
dc.identifier.scopuseid_2-s2.0-85049534850-
dc.identifier.volume20-
dc.identifier.issue4-
dc.identifier.spage324-
dc.identifier.epage329-
dc.identifier.eissn1745-7262-
dc.identifier.isiWOS:000437440200002-

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