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Article: Sensitisation profile of Chinese allergic rhinitis patients and effectiveness of a joint allergy-ENT clinic

TitleSensitisation profile of Chinese allergic rhinitis patients and effectiveness of a joint allergy-ENT clinic
Authors
KeywordsEndoscopy
Hong Kong
House dust mite
Pyroglyphidae
Sublingual immunotherapy
Issue Date2022
PublisherSpringer Medizin.
Citation
Allergo Journal International, 2022, p. 1-9 How to Cite?
AbstractPurpose: House dust mite (HDM) is the predominant cause of allergic rhinitis (AR) in Hong Kong but remains under-diagnosed and -treated. The association between patient-reported outcome measures (PROMs) and nasoendoscopy findings for AR have also not been investigated. This study investigated the demographics, sensitisation patterns, quality of life, use of sublingual immunotherapy and the association of PROMs and nasoendoscopy findings in AR patients through the first allergist-otorhinolaryngologists AR joint (ARJ) clinic in Hong Kong. Methods: This single-centred, retrospective observational study was conducted between January 2021 and December 2021. Clinical data from AR patients attending the ARJ clinic were analysed to identify the prevalence of HDM allergens, change in PROMs and the association of PROMs with nasoendoscopy scores. Results: The three most common sensitising HDM allergens were Dermatophagoides pterynosinus (94.4%), Dermatophagoides farinae (88.9%) and Euroglyphus maynei (88.9%). At the 13- to 32-week follow-up (median 28 weeks), patients who attended the ARJ clinic had significant improvement in Total Nasal Symptom Score (TNSS; p = 0.038). The visual analogue scale (VAS) was associated with nasoendoscopy score (p = 0.018). Patients using SLIT (sublingual immunotherapy) showed overall improvements in PROMs. Conclusion: The ARJ clinic significantly improved AR symptoms. SLIT was effective and safe for patients who failed conventional treatments. VAS positively correlated with nasoendoscopy findings. Testing for Dermatophagoides pterynosinus as a single agent during skin testing was sufficient for the diagnosis of HDM AR and should be prioritized when resources are restricted. Further studies should be done to investigate the treatment outcome of AR patients and the effectiveness of SLIT in the Chinese population.
Persistent Identifierhttp://hdl.handle.net/10722/314516
ISSN
2023 SCImago Journal Rankings: 0.526
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorHui, HKS-
dc.contributor.authorLi, TS-
dc.contributor.authorLo, WLW-
dc.contributor.authorKan, AKC-
dc.contributor.authorHo, SY-
dc.contributor.authorYeung, WYW-
dc.contributor.authorWong, JCY-
dc.contributor.authorChiang, V-
dc.contributor.authorWong, BYH-
dc.contributor.authorLi, PH-
dc.date.accessioned2022-07-22T05:26:01Z-
dc.date.available2022-07-22T05:26:01Z-
dc.date.issued2022-
dc.identifier.citationAllergo Journal International, 2022, p. 1-9-
dc.identifier.issn2197-0378-
dc.identifier.urihttp://hdl.handle.net/10722/314516-
dc.description.abstractPurpose: House dust mite (HDM) is the predominant cause of allergic rhinitis (AR) in Hong Kong but remains under-diagnosed and -treated. The association between patient-reported outcome measures (PROMs) and nasoendoscopy findings for AR have also not been investigated. This study investigated the demographics, sensitisation patterns, quality of life, use of sublingual immunotherapy and the association of PROMs and nasoendoscopy findings in AR patients through the first allergist-otorhinolaryngologists AR joint (ARJ) clinic in Hong Kong. Methods: This single-centred, retrospective observational study was conducted between January 2021 and December 2021. Clinical data from AR patients attending the ARJ clinic were analysed to identify the prevalence of HDM allergens, change in PROMs and the association of PROMs with nasoendoscopy scores. Results: The three most common sensitising HDM allergens were Dermatophagoides pterynosinus (94.4%), Dermatophagoides farinae (88.9%) and Euroglyphus maynei (88.9%). At the 13- to 32-week follow-up (median 28 weeks), patients who attended the ARJ clinic had significant improvement in Total Nasal Symptom Score (TNSS; p = 0.038). The visual analogue scale (VAS) was associated with nasoendoscopy score (p = 0.018). Patients using SLIT (sublingual immunotherapy) showed overall improvements in PROMs. Conclusion: The ARJ clinic significantly improved AR symptoms. SLIT was effective and safe for patients who failed conventional treatments. VAS positively correlated with nasoendoscopy findings. Testing for Dermatophagoides pterynosinus as a single agent during skin testing was sufficient for the diagnosis of HDM AR and should be prioritized when resources are restricted. Further studies should be done to investigate the treatment outcome of AR patients and the effectiveness of SLIT in the Chinese population.-
dc.languageeng-
dc.publisherSpringer Medizin.-
dc.relation.ispartofAllergo Journal International-
dc.subjectEndoscopy-
dc.subjectHong Kong-
dc.subjectHouse dust mite-
dc.subjectPyroglyphidae-
dc.subjectSublingual immunotherapy-
dc.titleSensitisation profile of Chinese allergic rhinitis patients and effectiveness of a joint allergy-ENT clinic-
dc.typeArticle-
dc.identifier.emailLi, PH: liphilip@hku.hk-
dc.identifier.authorityLi, PH=rp02669-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1007/s40629-022-00218-5-
dc.identifier.pmid35822075-
dc.identifier.pmcidPMC9261891-
dc.identifier.hkuros334365-
dc.identifier.spage1-
dc.identifier.epage9-
dc.publisher.placeGermany-

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