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Article: Pathogenicity, transmissibility, and fitness of SARS-CoV-2 Omicron in Syrian hamsters

TitlePathogenicity, transmissibility, and fitness of SARS-CoV-2 Omicron in Syrian hamsters
Authors
Issue Date2022
Citation
Science, 2022, v. 377, n. 6604, p. 428-433 How to Cite?
AbstractThe in vivo pathogenicity, transmissibility, and fitness of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron (B.1.1.529) variant are not well understood. We compared these virological attributes of this new variant of concern (VOC) with those of the Delta (B.1.617.2) variant in a Syrian hamster model of COVID-19. Omicron-infected hamsters lost significantly less body weight and exhibited reduced clinical scores, respiratory tract viral burdens, cytokine and chemokine dysregulation, and lung damage than Delta-infected hamsters. Both variants were highly transmissible through contact transmission. In noncontact transmission studies Omicron demonstrated similar or higher transmissibility than Delta. Delta outcompeted Omicron without selection pressure, but this scenario changed once immune selection pressure with neutralizing antibodies - active against Delta but poorly active against Omicron - was introduced. Next-generation vaccines and antivirals effective against this new VOC are therefore urgently needed.
Persistent Identifierhttp://hdl.handle.net/10722/315208
ISSN
2021 Impact Factor: 63.714
2020 SCImago Journal Rankings: 12.556
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYuan, Shuofeng-
dc.contributor.authorYe, Zi Wei-
dc.contributor.authorLiang, Ronghui-
dc.contributor.authorTang, Kaiming-
dc.contributor.authorZhang, Anna Jinxia-
dc.contributor.authorLu, Gang-
dc.contributor.authorOng, Chon Phin-
dc.contributor.authorPoon, Vincent Kwok Man-
dc.contributor.authorChan, Chris Chung Sing-
dc.contributor.authorMok, Bobo Wing Yee-
dc.contributor.authorQin, Zhenzhi-
dc.contributor.authorXie, Yubin-
dc.contributor.authorChu, Allen Wing Ho-
dc.contributor.authorChan, Wan Mui-
dc.contributor.authorIp, Jonathan Daniel-
dc.contributor.authorSun, Haoran-
dc.contributor.authorTsang, Jessica Oi Ling-
dc.contributor.authorYuen, Terrence Tsz Tai-
dc.contributor.authorChik, Kenn Ka Heng-
dc.contributor.authorChan, Chris Chun Yiu-
dc.contributor.authorCai, Jian Piao-
dc.contributor.authorLuo, Cuiting-
dc.contributor.authorLu, Lu-
dc.contributor.authorYip, Cyril Chik Yan-
dc.contributor.authorChu, Hin-
dc.contributor.authorTo, Kelvin Kai Wang-
dc.contributor.authorChen, Honglin-
dc.contributor.authorJin, Dong Yan-
dc.contributor.authorYuen, Kwok Yung-
dc.contributor.authorChan, Jasper Fuk Woo-
dc.date.accessioned2022-08-05T10:18:03Z-
dc.date.available2022-08-05T10:18:03Z-
dc.date.issued2022-
dc.identifier.citationScience, 2022, v. 377, n. 6604, p. 428-433-
dc.identifier.issn0036-8075-
dc.identifier.urihttp://hdl.handle.net/10722/315208-
dc.description.abstractThe in vivo pathogenicity, transmissibility, and fitness of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron (B.1.1.529) variant are not well understood. We compared these virological attributes of this new variant of concern (VOC) with those of the Delta (B.1.617.2) variant in a Syrian hamster model of COVID-19. Omicron-infected hamsters lost significantly less body weight and exhibited reduced clinical scores, respiratory tract viral burdens, cytokine and chemokine dysregulation, and lung damage than Delta-infected hamsters. Both variants were highly transmissible through contact transmission. In noncontact transmission studies Omicron demonstrated similar or higher transmissibility than Delta. Delta outcompeted Omicron without selection pressure, but this scenario changed once immune selection pressure with neutralizing antibodies - active against Delta but poorly active against Omicron - was introduced. Next-generation vaccines and antivirals effective against this new VOC are therefore urgently needed.-
dc.languageeng-
dc.relation.ispartofScience-
dc.titlePathogenicity, transmissibility, and fitness of SARS-CoV-2 Omicron in Syrian hamsters-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1126/science.abn8939-
dc.identifier.pmid35737809-
dc.identifier.scopuseid_2-s2.0-85134504514-
dc.identifier.volume377-
dc.identifier.issue6604-
dc.identifier.spage428-
dc.identifier.epage433-
dc.identifier.eissn1095-9203-
dc.identifier.isiWOS:000830834600040-

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