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Article: Risk factors of nephrotoxicity of maintenance pemetrexed in patients with metastatic non-squamous non-small cell carcinoma of lung

TitleRisk factors of nephrotoxicity of maintenance pemetrexed in patients with metastatic non-squamous non-small cell carcinoma of lung
Authors
KeywordsChemotherapy
Lung cancer
Nephrotoxicity
Pemetrexed
Issue Date2021
Citation
Lung Cancer, 2021, v. 162, p. 169-174 How to Cite?
AbstractBackground: Nephrotoxicity is one of the concerns of prolonged maintenance therapy with pemetrexed. No reversible risk factors for pemetrexed-induced nephrotoxicity have been identified in previous studies. Identification of such factors would be clinically meaningful to maximize the chemotherapeutic benefits by avoiding premature termination of maintenance therapy which might otherwise result from the development of renal impairment. Methods: This was a retrospective single-center cohort study conducted in Queen Mary Hospital in Hong Kong. The study included 134 patients with advanced stage non-squamous NSCLC that received first line pemetrexed-platinum doublets followed by maintenance pemetrexed. The primary endpoint was the occurrence of nephrotoxicity. The risk factors of nephrotoxicity were identified. Results: Presence of non-evacuated third-space fluid during treatment course (OR 4.185, 95% CI = 1.150–15.191, p-value 0.030), the use of cisplatin (instead of carboplatin) during the induction phase (OR 8.761, 95% CI = 1.684–45.577, p-value 0.010) and receiving more than 15 cycles of maintenance pemetrexed (OR 3.839, 95% CI = 1.022–14.413, p-value 0.046) were identified as independent risk factors to the development of nephrotoxicity associated with maintenance pemetrexed use. Conclusions: In order to reduce the risk of development of nephrotoxicity in NSCLC patient receiving first-line pemetrexed-platinum doublets, third-space fluid should be evacuated and carboplatin should be chosen over cisplatin whenever possible.
Persistent Identifierhttp://hdl.handle.net/10722/315369
ISSN
2023 Impact Factor: 4.5
2023 SCImago Journal Rankings: 1.761
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKwok, Wang Chun-
dc.contributor.authorChiang, Ka Yan-
dc.contributor.authorHo, James Chung Man-
dc.contributor.authorLam, David Chi Leung-
dc.contributor.authorIp, Mary Sau Man-
dc.contributor.authorTam, Terence Chi Chun-
dc.date.accessioned2022-08-05T10:18:38Z-
dc.date.available2022-08-05T10:18:38Z-
dc.date.issued2021-
dc.identifier.citationLung Cancer, 2021, v. 162, p. 169-174-
dc.identifier.issn0169-5002-
dc.identifier.urihttp://hdl.handle.net/10722/315369-
dc.description.abstractBackground: Nephrotoxicity is one of the concerns of prolonged maintenance therapy with pemetrexed. No reversible risk factors for pemetrexed-induced nephrotoxicity have been identified in previous studies. Identification of such factors would be clinically meaningful to maximize the chemotherapeutic benefits by avoiding premature termination of maintenance therapy which might otherwise result from the development of renal impairment. Methods: This was a retrospective single-center cohort study conducted in Queen Mary Hospital in Hong Kong. The study included 134 patients with advanced stage non-squamous NSCLC that received first line pemetrexed-platinum doublets followed by maintenance pemetrexed. The primary endpoint was the occurrence of nephrotoxicity. The risk factors of nephrotoxicity were identified. Results: Presence of non-evacuated third-space fluid during treatment course (OR 4.185, 95% CI = 1.150–15.191, p-value 0.030), the use of cisplatin (instead of carboplatin) during the induction phase (OR 8.761, 95% CI = 1.684–45.577, p-value 0.010) and receiving more than 15 cycles of maintenance pemetrexed (OR 3.839, 95% CI = 1.022–14.413, p-value 0.046) were identified as independent risk factors to the development of nephrotoxicity associated with maintenance pemetrexed use. Conclusions: In order to reduce the risk of development of nephrotoxicity in NSCLC patient receiving first-line pemetrexed-platinum doublets, third-space fluid should be evacuated and carboplatin should be chosen over cisplatin whenever possible.-
dc.languageeng-
dc.relation.ispartofLung Cancer-
dc.subjectChemotherapy-
dc.subjectLung cancer-
dc.subjectNephrotoxicity-
dc.subjectPemetrexed-
dc.titleRisk factors of nephrotoxicity of maintenance pemetrexed in patients with metastatic non-squamous non-small cell carcinoma of lung-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.lungcan.2021.11.005-
dc.identifier.pmid34823107-
dc.identifier.scopuseid_2-s2.0-85119421231-
dc.identifier.volume162-
dc.identifier.spage169-
dc.identifier.epage174-
dc.identifier.eissn1872-8332-
dc.identifier.isiWOS:000724823600005-

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