File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: A canine model for production of severe unilateral panacinar emphysema

TitleA canine model for production of severe unilateral panacinar emphysema
Authors
KeywordsCanine
Elastase
Emphysema
Panacinar
Issue Date2004
Citation
Experimental Lung Research, 2004, v. 30, n. 4, p. 319-332 How to Cite?
AbstractThe authors created a canine model of severe emphysema using whole lung lavage to deliver repeated porcine pancreatic elastase solution to the terminal airways and alveoli of the right lung. This model produces extreme unilateral panacinar emphysema closely resembling that encountered in patients with α1-antitrypsin deficiency. Because the contralateral lung remains functional, the animals can be maintained indefinitely. The model will be of value in developing imaging techniques capable of safely evaluating the effect of treatment on panacinar emphysema in α1-antitrypsin- deficient patients.
Persistent Identifierhttp://hdl.handle.net/10722/315965
ISSN
2023 Impact Factor: 1.5
2023 SCImago Journal Rankings: 0.493

 

DC FieldValueLanguage
dc.contributor.authorChino, Kimiaki-
dc.contributor.authorChoong, Cliff K.-
dc.contributor.authorToeniskoefler, P. Diane-
dc.contributor.authorCooper, Joel D.-
dc.contributor.authorLausberg, Henning F.-
dc.contributor.authorBae, Kyongtae T.-
dc.contributor.authorPierce, John A.-
dc.contributor.authorHogg, James C.-
dc.date.accessioned2022-08-24T15:48:45Z-
dc.date.available2022-08-24T15:48:45Z-
dc.date.issued2004-
dc.identifier.citationExperimental Lung Research, 2004, v. 30, n. 4, p. 319-332-
dc.identifier.issn0190-2148-
dc.identifier.urihttp://hdl.handle.net/10722/315965-
dc.description.abstractThe authors created a canine model of severe emphysema using whole lung lavage to deliver repeated porcine pancreatic elastase solution to the terminal airways and alveoli of the right lung. This model produces extreme unilateral panacinar emphysema closely resembling that encountered in patients with α1-antitrypsin deficiency. Because the contralateral lung remains functional, the animals can be maintained indefinitely. The model will be of value in developing imaging techniques capable of safely evaluating the effect of treatment on panacinar emphysema in α1-antitrypsin- deficient patients.-
dc.languageeng-
dc.relation.ispartofExperimental Lung Research-
dc.subjectCanine-
dc.subjectElastase-
dc.subjectEmphysema-
dc.subjectPanacinar-
dc.titleA canine model for production of severe unilateral panacinar emphysema-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1080/01902140490439022-
dc.identifier.pmid15204837-
dc.identifier.scopuseid_2-s2.0-2642584282-
dc.identifier.volume30-
dc.identifier.issue4-
dc.identifier.spage319-
dc.identifier.epage332-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats