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Article: Determinants of renal volume in autosomal-dominant polycystic kidney disease

TitleDeterminants of renal volume in autosomal-dominant polycystic kidney disease
Authors
KeywordsCell growth
Polycystic kidney
Prolifiration cyst volume
Renal cysts
Tubules
Issue Date2008
Citation
Kidney International, 2008, v. 73, n. 1, p. 108-116 How to Cite?
AbstractThe Consortium of Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) recently showed that renal enlargement in autosomal-dominant polycystic kidney disease mimicked exponential growth. We determined the effects of cyst initiation rate, total number, and growth rate on the time-dependent change of total cyst volume (TCV). Mathematical models with equations integrating cyst surface area, volume, and an invariant growth rate constant were used to compute the time-dependent change in volume of solitary and multiple cysts. Multiple expanding cysts increased TCV in an exponential-like pattern even when individual cysts formed at different rates or exhibited different but constant growth rates. TCV depended on the rate of cyst initiation and on the total number of cysts; however, the compounding effect of exponential-like growth was the most powerful determinant of long-term cyst expansion. Extrapolation of TCV data plots for individual subjects back to an age of 18 predicted TCV values within an established range. We conclude that cysts started early in life were the main contributor to eventual TCV while their growth rate primarily determined renal size; although the rate of formation and the ultimate number of cysts also contributed. The good fit between the exponential models and the extrapolated CRISP data indicates that the TCV growth rate is a defining trait for individual patients and may be used as a prognostic marker. © 2008 International Society of Nephrology.
Persistent Identifierhttp://hdl.handle.net/10722/315994
ISSN
2023 Impact Factor: 14.8
2023 SCImago Journal Rankings: 3.886
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorGrantham, J. J.-
dc.contributor.authorCook, L. T.-
dc.contributor.authorTorres, V. E.-
dc.contributor.authorBost, J. E.-
dc.contributor.authorChapman, A. B.-
dc.contributor.authorHarris, P. C.-
dc.contributor.authorGuay-Woodford, L. M.-
dc.contributor.authorBae, K. T.-
dc.date.accessioned2022-08-24T15:48:52Z-
dc.date.available2022-08-24T15:48:52Z-
dc.date.issued2008-
dc.identifier.citationKidney International, 2008, v. 73, n. 1, p. 108-116-
dc.identifier.issn0085-2538-
dc.identifier.urihttp://hdl.handle.net/10722/315994-
dc.description.abstractThe Consortium of Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) recently showed that renal enlargement in autosomal-dominant polycystic kidney disease mimicked exponential growth. We determined the effects of cyst initiation rate, total number, and growth rate on the time-dependent change of total cyst volume (TCV). Mathematical models with equations integrating cyst surface area, volume, and an invariant growth rate constant were used to compute the time-dependent change in volume of solitary and multiple cysts. Multiple expanding cysts increased TCV in an exponential-like pattern even when individual cysts formed at different rates or exhibited different but constant growth rates. TCV depended on the rate of cyst initiation and on the total number of cysts; however, the compounding effect of exponential-like growth was the most powerful determinant of long-term cyst expansion. Extrapolation of TCV data plots for individual subjects back to an age of 18 predicted TCV values within an established range. We conclude that cysts started early in life were the main contributor to eventual TCV while their growth rate primarily determined renal size; although the rate of formation and the ultimate number of cysts also contributed. The good fit between the exponential models and the extrapolated CRISP data indicates that the TCV growth rate is a defining trait for individual patients and may be used as a prognostic marker. © 2008 International Society of Nephrology.-
dc.languageeng-
dc.relation.ispartofKidney International-
dc.subjectCell growth-
dc.subjectPolycystic kidney-
dc.subjectProlifiration cyst volume-
dc.subjectRenal cysts-
dc.subjectTubules-
dc.titleDeterminants of renal volume in autosomal-dominant polycystic kidney disease-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/sj.ki.5002624-
dc.identifier.pmid17960141-
dc.identifier.scopuseid_2-s2.0-37249043883-
dc.identifier.volume73-
dc.identifier.issue1-
dc.identifier.spage108-
dc.identifier.epage116-
dc.identifier.eissn1523-1755-
dc.identifier.isiWOS:000251945900014-

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