File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Novel methodology to evaluate renal cysts in polycystic kidney disease

TitleNovel methodology to evaluate renal cysts in polycystic kidney disease
Authors
KeywordsKidney
Magnetic resonance imaging
Polycystic kidney disease
Renal cysts
Segmentation
Issue Date2014
Citation
American Journal of Nephrology, 2014, v. 39, n. 3, p. 210-217 How to Cite?
AbstractAim: To develop and assess a semiautomated method for segmenting and counting individual renal cysts from mid-slice MR images in patients with autosomal dominant polycystic kidney disease (ADPKD). Methods: A semiautomated method was developed to segment and count individual renal cysts from mid-slice MR images in 241 subjects with ADPKD from the Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease. For each subject, a mid-slice MR image was selected from each set of coronal T2-weighted MR images covering the entire kidney. The selected mid-slice image was processed with the semiautomated method to segment and count individual renal cysts. The number of cysts from the mid-slice image of each kidney was also measured by manual counting. The level of agreement between the semiautomated and manual cyst counts was compared using intraclass correlation (ICC) and a Bland-Altman plot. Results: Individual renal cysts were successfully segmented using the semiautomated method in all 241 cases. The number of cysts in each kidney measured with the semiautomated and manual counting methods correlated well (ICC = 0.96 for the right or left kidney), with a small average difference (-0.52, with higher semiautomated counts, for the right kidney, and 0.13, with higher manual counts, for the left kidney) in the semiautomated method. However, there was substantial variation in a small number of subjects; 6 of 241 participants (2.5%) had a difference in the total cyst count of more than 15. Conclusion: We have developed a semiautomated method to segment individual renal cysts from mid-slice MR images in ADPKD kidneys as a quantitative indicator of characterization and disease progression of ADPKD. © 2014 S. Karger AG, Basel.
Persistent Identifierhttp://hdl.handle.net/10722/316092
ISSN
2023 Impact Factor: 4.3
2023 SCImago Journal Rankings: 1.218
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorBae, Kyongtae T.-
dc.contributor.authorSun, Hongliang-
dc.contributor.authorLee, June Goo-
dc.contributor.authorBae, Kyungsoo-
dc.contributor.authorWang, Jinhong-
dc.contributor.authorTao, Cheng-
dc.contributor.authorChapman, Arlene B.-
dc.contributor.authorTorres, Vicente E.-
dc.contributor.authorGrantham, Jared J.-
dc.contributor.authorMrug, Michal-
dc.contributor.authorBennett, William M.-
dc.contributor.authorFlessner, Michael F.-
dc.contributor.authorLandsittel, Doug P.-
dc.date.accessioned2022-08-24T15:49:13Z-
dc.date.available2022-08-24T15:49:13Z-
dc.date.issued2014-
dc.identifier.citationAmerican Journal of Nephrology, 2014, v. 39, n. 3, p. 210-217-
dc.identifier.issn0250-8095-
dc.identifier.urihttp://hdl.handle.net/10722/316092-
dc.description.abstractAim: To develop and assess a semiautomated method for segmenting and counting individual renal cysts from mid-slice MR images in patients with autosomal dominant polycystic kidney disease (ADPKD). Methods: A semiautomated method was developed to segment and count individual renal cysts from mid-slice MR images in 241 subjects with ADPKD from the Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease. For each subject, a mid-slice MR image was selected from each set of coronal T2-weighted MR images covering the entire kidney. The selected mid-slice image was processed with the semiautomated method to segment and count individual renal cysts. The number of cysts from the mid-slice image of each kidney was also measured by manual counting. The level of agreement between the semiautomated and manual cyst counts was compared using intraclass correlation (ICC) and a Bland-Altman plot. Results: Individual renal cysts were successfully segmented using the semiautomated method in all 241 cases. The number of cysts in each kidney measured with the semiautomated and manual counting methods correlated well (ICC = 0.96 for the right or left kidney), with a small average difference (-0.52, with higher semiautomated counts, for the right kidney, and 0.13, with higher manual counts, for the left kidney) in the semiautomated method. However, there was substantial variation in a small number of subjects; 6 of 241 participants (2.5%) had a difference in the total cyst count of more than 15. Conclusion: We have developed a semiautomated method to segment individual renal cysts from mid-slice MR images in ADPKD kidneys as a quantitative indicator of characterization and disease progression of ADPKD. © 2014 S. Karger AG, Basel.-
dc.languageeng-
dc.relation.ispartofAmerican Journal of Nephrology-
dc.subjectKidney-
dc.subjectMagnetic resonance imaging-
dc.subjectPolycystic kidney disease-
dc.subjectRenal cysts-
dc.subjectSegmentation-
dc.titleNovel methodology to evaluate renal cysts in polycystic kidney disease-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1159/000358604-
dc.identifier.pmid24576800-
dc.identifier.scopuseid_2-s2.0-84895656752-
dc.identifier.volume39-
dc.identifier.issue3-
dc.identifier.spage210-
dc.identifier.epage217-
dc.identifier.eissn1421-9670-
dc.identifier.isiWOS:000334156700004-
dc.identifier.f1000718293582-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats