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Article: A comparison of ultrasound and magnetic resonance imaging shows that kidney length predicts chronic kidney disease in autosomal dominant polycystic kidney disease

TitleA comparison of ultrasound and magnetic resonance imaging shows that kidney length predicts chronic kidney disease in autosomal dominant polycystic kidney disease
Authors
KeywordsMagnetic resonance imaging
Total kidney volume
Ultrasound
Issue Date2015
Citation
Kidney International, 2015, v. 88, n. 1, p. 146-151 How to Cite?
AbstractAutosomal dominant polycystic kidney disease (ADPKD) is marked by gradual renal cyst and kidney enlargement and ultimately renal failure. Magnetic resonance-based, height-adjusted total kidney volume (htTKV) over 600 cc/m predicts the development of CKD stage 3 within 8 years in the Consortium for Radiologic Imaging in Polycystic Kidney Disease cohort. Here we compared simultaneous ultrasound and magnetic resonance imaging to determine whether ultrasound and kidney length (KL) predict future CKD stage 3 over longer periods of follow-up. A total of 241 ADPKD patients, 15-46 years, with creatinine clearance of 70 ml/min and above had iothalamate clearance, magnetic resonance, and ultrasound evaluations. Participants underwent an average of five repeat clearance measurements over a mean follow-up of 9.3 years. Ultrasound and magnetic resonance-based TKV and KL were compared using Bland-Altman plots and intraclass correlations. Each measure was tested to predict future CKD stage 3. Relatively strong intraclass correlations between ultrasound and magnetic resonance were found for both htTKV and KL (0.81 and 0.85, respectively). Ultrasound and magnetic resonance-based htTKV and KL predicted future CKD stage 3 similarly (AUC of 0.87, 0.88, 0.87, and 0.88, respectively). An ultrasound kidney length over 16.5 cm and htTKV over 650 ml/min had the best cut point for predicting the development of CKD stage 3. Thus, kidney length alone is sufficient to stratify the risk of progression to renal insufficiency early in ADPKD using either ultrasound or magnetic resonance imaging.
Persistent Identifierhttp://hdl.handle.net/10722/316109
ISSN
2023 Impact Factor: 14.8
2023 SCImago Journal Rankings: 3.886
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorBhutani, Harpreet-
dc.contributor.authorSmith, Vikram-
dc.contributor.authorRahbari-Oskoui, Frederic-
dc.contributor.authorMittal, Ankush-
dc.contributor.authorGrantham, Jared J.-
dc.contributor.authorTorres, Vicente E.-
dc.contributor.authorMrug, Michal-
dc.contributor.authorBae, Kyongtae T.-
dc.contributor.authorWu, Zhiyuan-
dc.contributor.authorGe, Yinghui-
dc.contributor.authorLandslittel, Doug-
dc.contributor.authorGibbs, Patrice-
dc.contributor.authorO'Neill, W. Charles-
dc.contributor.authorChapman, Arlene B.-
dc.date.accessioned2022-08-24T15:49:16Z-
dc.date.available2022-08-24T15:49:16Z-
dc.date.issued2015-
dc.identifier.citationKidney International, 2015, v. 88, n. 1, p. 146-151-
dc.identifier.issn0085-2538-
dc.identifier.urihttp://hdl.handle.net/10722/316109-
dc.description.abstractAutosomal dominant polycystic kidney disease (ADPKD) is marked by gradual renal cyst and kidney enlargement and ultimately renal failure. Magnetic resonance-based, height-adjusted total kidney volume (htTKV) over 600 cc/m predicts the development of CKD stage 3 within 8 years in the Consortium for Radiologic Imaging in Polycystic Kidney Disease cohort. Here we compared simultaneous ultrasound and magnetic resonance imaging to determine whether ultrasound and kidney length (KL) predict future CKD stage 3 over longer periods of follow-up. A total of 241 ADPKD patients, 15-46 years, with creatinine clearance of 70 ml/min and above had iothalamate clearance, magnetic resonance, and ultrasound evaluations. Participants underwent an average of five repeat clearance measurements over a mean follow-up of 9.3 years. Ultrasound and magnetic resonance-based TKV and KL were compared using Bland-Altman plots and intraclass correlations. Each measure was tested to predict future CKD stage 3. Relatively strong intraclass correlations between ultrasound and magnetic resonance were found for both htTKV and KL (0.81 and 0.85, respectively). Ultrasound and magnetic resonance-based htTKV and KL predicted future CKD stage 3 similarly (AUC of 0.87, 0.88, 0.87, and 0.88, respectively). An ultrasound kidney length over 16.5 cm and htTKV over 650 ml/min had the best cut point for predicting the development of CKD stage 3. Thus, kidney length alone is sufficient to stratify the risk of progression to renal insufficiency early in ADPKD using either ultrasound or magnetic resonance imaging.-
dc.languageeng-
dc.relation.ispartofKidney International-
dc.subjectMagnetic resonance imaging-
dc.subjectTotal kidney volume-
dc.subjectUltrasound-
dc.titleA comparison of ultrasound and magnetic resonance imaging shows that kidney length predicts chronic kidney disease in autosomal dominant polycystic kidney disease-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/ki.2015.71-
dc.identifier.pmid25830764-
dc.identifier.scopuseid_2-s2.0-84934436868-
dc.identifier.volume88-
dc.identifier.issue1-
dc.identifier.spage146-
dc.identifier.epage151-
dc.identifier.eissn1523-1755-
dc.identifier.isiWOS:000357138000019-
dc.identifier.f1000725416014-

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