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Article: Overweight and Obesity Are Predictors of Progression in Early Autosomal Dominant Polycystic Kidney Disease

TitleOverweight and Obesity Are Predictors of Progression in Early Autosomal Dominant Polycystic Kidney Disease
Authors
Issue Date2018
Citation
Journal of the American Society of Nephrology, 2018, v. 29, n. 2, p. 571-578 How to Cite?
AbstractThe association of overweight/obesity with disease progression in patients with autosomal dominant polycystic kidney disease (ADPKD) remains untested. We hypothesized that overweight/obesity associates with faster progression in early-stage ADPKD. Overall, 441 nondiabetic participants with ADPKD and an eGFR.60 ml/min per 1.73 m2 who participated in the Halt Progression of Polycystic Kidney Disease Study A were categorized on the basis of body mass index (BMI; calculated using nonkidney and nonliver weight) as normal weight (18.5-24.9 kg/m2; reference; n=192), overweight (25.0-29.9 kg/m2; n=168), or obese ($30 kg/m2; n=81). We evaluated the longitudinal (5-year) association of overweight/obesity with change in total kidney volume (TKV) by magnetic resonance imaging using linear regression and multinomial logistic regression models. Among participants, mean6SD age was 3768 years, annual percent change in TKV was 7.4%65.1%, and BMI was 26.364.9 kg/m2. The annual percent change in TKV increased with increasing BMI category (normal weight: 6.1%64.7%, overweight: 7.9%64.8%, obese: 9.4%66.2%; P,0.001). In the fully adjusted model, higher BMI associated with greater annual percent change in TKV (b=0.79; 95% confidence interval [95% CI], 0.18 to 1.39, per 5-unit increase in BMI). Overweight and obesity associated with increased odds of annual percent change in TKV $7% compared with,5% (overweight: odds ratio, 2.02; 95% CI, 1.15 to 3.56; obese: odds ratio, 3.76; 95% CI, 1.81 to 7.80). Obesity also independently associated with greater eGFR decline (slope) versus normal weight (fully adjusted b =20.08; 95% CI, 20.15 to 20.02). In conclusion, overweight and, particularly, obesity are strongly and independently associated with rate of progression in early-stage ADPKD.
Persistent Identifierhttp://hdl.handle.net/10722/316164
ISSN
2023 Impact Factor: 10.3
2023 SCImago Journal Rankings: 3.409
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorNowak, Kristen L.-
dc.contributor.authorYou, Zhiying-
dc.contributor.authorGitomer, Berenice-
dc.contributor.authorBrosnahan, Godela-
dc.contributor.authorTorres, Vicente E.-
dc.contributor.authorChapman, Arlene B.-
dc.contributor.authorPerrone, Ronald D.-
dc.contributor.authorSteinman, Theodore I.-
dc.contributor.authorAbebe, Kaleab Z.-
dc.contributor.authorRahbari-Oskoui, Frederic F.-
dc.contributor.authorYu, Alan S.L.-
dc.contributor.authorHarris, Peter C.-
dc.contributor.authorBae, Kyongtae T.-
dc.contributor.authorHogan, Marie-
dc.contributor.authorMiskulin, Dana-
dc.contributor.authorChonchol, Michel-
dc.date.accessioned2022-08-24T15:49:28Z-
dc.date.available2022-08-24T15:49:28Z-
dc.date.issued2018-
dc.identifier.citationJournal of the American Society of Nephrology, 2018, v. 29, n. 2, p. 571-578-
dc.identifier.issn1046-6673-
dc.identifier.urihttp://hdl.handle.net/10722/316164-
dc.description.abstractThe association of overweight/obesity with disease progression in patients with autosomal dominant polycystic kidney disease (ADPKD) remains untested. We hypothesized that overweight/obesity associates with faster progression in early-stage ADPKD. Overall, 441 nondiabetic participants with ADPKD and an eGFR.60 ml/min per 1.73 m2 who participated in the Halt Progression of Polycystic Kidney Disease Study A were categorized on the basis of body mass index (BMI; calculated using nonkidney and nonliver weight) as normal weight (18.5-24.9 kg/m2; reference; n=192), overweight (25.0-29.9 kg/m2; n=168), or obese ($30 kg/m2; n=81). We evaluated the longitudinal (5-year) association of overweight/obesity with change in total kidney volume (TKV) by magnetic resonance imaging using linear regression and multinomial logistic regression models. Among participants, mean6SD age was 3768 years, annual percent change in TKV was 7.4%65.1%, and BMI was 26.364.9 kg/m2. The annual percent change in TKV increased with increasing BMI category (normal weight: 6.1%64.7%, overweight: 7.9%64.8%, obese: 9.4%66.2%; P,0.001). In the fully adjusted model, higher BMI associated with greater annual percent change in TKV (b=0.79; 95% confidence interval [95% CI], 0.18 to 1.39, per 5-unit increase in BMI). Overweight and obesity associated with increased odds of annual percent change in TKV $7% compared with,5% (overweight: odds ratio, 2.02; 95% CI, 1.15 to 3.56; obese: odds ratio, 3.76; 95% CI, 1.81 to 7.80). Obesity also independently associated with greater eGFR decline (slope) versus normal weight (fully adjusted b =20.08; 95% CI, 20.15 to 20.02). In conclusion, overweight and, particularly, obesity are strongly and independently associated with rate of progression in early-stage ADPKD.-
dc.languageeng-
dc.relation.ispartofJournal of the American Society of Nephrology-
dc.titleOverweight and Obesity Are Predictors of Progression in Early Autosomal Dominant Polycystic Kidney Disease-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1681/ASN.2017070819-
dc.identifier.pmid29118087-
dc.identifier.scopuseid_2-s2.0-85041477827-
dc.identifier.volume29-
dc.identifier.issue2-
dc.identifier.spage571-
dc.identifier.epage578-
dc.identifier.eissn1533-3450-
dc.identifier.isiWOS:000424142700026-
dc.identifier.f1000732096513-

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