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Article: The Architecture of Inactivated SARS-CoV-2 with Postfusion Spikes Revealed by Cryo-EM and Cryo-ET

TitleThe Architecture of Inactivated SARS-CoV-2 with Postfusion Spikes Revealed by Cryo-EM and Cryo-ET
Authors
Liu, ChuangMendonça, LuizaYang, YangGao, YuanzhuShen, ChenguangLiu, JiweiNi, TaoJu, BinLiu, CongcongTang, XianWei, JinliMa, XiaominZhu, YananLiu, WeilongXu, ShumanLiu, YingxiaYuan, JingWu, JingLiu, ZhengZhang, ZhengLiu, LeiWang, PeiyiZhang, Peijun
KeywordsCOVID-19
cryo-EM
cryo-ET
glycosylation
postfusion
SARS-CoV-2
spike
subtomogram averaging
vaccine
β-propiolactone-inactivated viruses
Issue Date2020
Citation
Structure, 2020, v. 28, n. 11, p. 1218-1224.e4 How to Cite?
DOI: http://dx.doi.org/10.1016/j.str.2020.10.001
AbstractSeveral vaccine candidates using inactivated SARS-CoV-2 viruses are under development. Liu et al. used state-of-the-art cryoelectron microscopy technologies to characterize the architecture of inactivated SARS-CoV-2 viruses. They found that the viral spikes are mostly in a postfusion state, which is not desirable for vaccine development.
Persistent Identifierhttp://hdl.handle.net/10722/316558
ISSN
0969-2126
2021 Impact Factor: 5.871
2020 SCImago Journal Rankings: 2.907
PubMed Central ID
PMC7557167
ISI Accession Number ID
WOS:000587327300006

 

DC FieldValueLanguage
dc.contributor.authorLiu, Chuang-
dc.contributor.authorMendonça, Luiza-
dc.contributor.authorYang, Yang-
dc.contributor.authorGao, Yuanzhu-
dc.contributor.authorShen, Chenguang-
dc.contributor.authorLiu, Jiwei-
dc.contributor.authorNi, Tao-
dc.contributor.authorJu, Bin-
dc.contributor.authorLiu, Congcong-
dc.contributor.authorTang, Xian-
dc.contributor.authorWei, Jinli-
dc.contributor.authorMa, Xiaomin-
dc.contributor.authorZhu, Yanan-
dc.contributor.authorLiu, Weilong-
dc.contributor.authorXu, Shuman-
dc.contributor.authorLiu, Yingxia-
dc.contributor.authorYuan, Jing-
dc.contributor.authorWu, Jing-
dc.contributor.authorLiu, Zheng-
dc.contributor.authorZhang, Zheng-
dc.contributor.authorLiu, Lei-
dc.contributor.authorWang, Peiyi-
dc.contributor.authorZhang, Peijun-
dc.date.accessioned2022-09-14T11:40:44Z-
dc.date.available2022-09-14T11:40:44Z-
dc.date.issued2020-
dc.identifier.citationStructure, 2020, v. 28, n. 11, p. 1218-1224.e4-
dc.identifier.issn0969-2126-
dc.identifier.urihttp://hdl.handle.net/10722/316558-
dc.description.abstractSeveral vaccine candidates using inactivated SARS-CoV-2 viruses are under development. Liu et al. used state-of-the-art cryoelectron microscopy technologies to characterize the architecture of inactivated SARS-CoV-2 viruses. They found that the viral spikes are mostly in a postfusion state, which is not desirable for vaccine development.-
dc.languageeng-
dc.relation.ispartofStructure-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectCOVID-19-
dc.subjectcryo-EM-
dc.subjectcryo-ET-
dc.subjectglycosylation-
dc.subjectpostfusion-
dc.subjectSARS-CoV-2-
dc.subjectspike-
dc.subjectsubtomogram averaging-
dc.subjectvaccine-
dc.subjectβ-propiolactone-inactivated viruses-
dc.titleThe Architecture of Inactivated SARS-CoV-2 with Postfusion Spikes Revealed by Cryo-EM and Cryo-ET-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1016/j.str.2020.10.001-
dc.identifier.pmid33058760-
dc.identifier.pmcidPMC7557167-
dc.identifier.scopuseid_2-s2.0-85092693017-
dc.identifier.volume28-
dc.identifier.issue11-
dc.identifier.spage1218-
dc.identifier.epage1224.e4-
dc.identifier.eissn1878-4186-
dc.identifier.isiWOS:000587327300006-

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