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Article: Microstructured Surfaces for Reducing Chances of Fomite Transmission via Virus-Containing Respiratory Droplets

TitleMicrostructured Surfaces for Reducing Chances of Fomite Transmission via Virus-Containing Respiratory Droplets
Authors
Keywordsdirectional particle aggregation
fomite transmission
microstructured surfaces
nanoparticles
respiratory droplets
virus particles
Issue Date2021
Citation
ACS Nano, 2021, v. 15, n. 9, p. 14049-14060 How to Cite?
AbstractEvaporation-induced particle aggregation in drying droplets is of significant importance in the prevention of pathogen transfer due to the possibility of indirect fomite transmission of the infectious virus particles. In this study, particle aggregation was directionally controlled using contact line dynamics (pinned or slipping) and geometrical gradients on microstructured surfaces by the systematic investigation of the evaporation process on sessile droplets and sprayed microdroplets laden with virus-simulant nanoparticles. Using this mechanism, we designed robust particle capture surfaces by significantly inhibiting the contact transfer of particles from fomite surfaces. For the proof-of-concept, interconnected hexagonal and inverted pyramidal microwall were fabricated using ultraviolet-based nanoimprint lithography, which is considered to be a promising scalable manufacturing process. We demonstrated the potentials of an engineered microcavity surface to limit the contact transfer of particle aggregates deposited with the evaporation of microdroplets by 93% for hexagonal microwall and by 96% for inverted pyramidal microwall. The particle capture potential of the interconnected microstructures was also investigated using biological particles, including adenoviruses and lung-derived extracellular vesicles. The findings indicate that the proposed microstructured surfaces can reduce the indirect fomite transmission of highly infectious agents, including norovirus, rotavirus, or SARS-CoV-2, via respiratory droplets.
Persistent Identifierhttp://hdl.handle.net/10722/318945
ISSN
2023 Impact Factor: 15.8
2023 SCImago Journal Rankings: 4.593
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKim, Seok-
dc.contributor.authorKim, Woo Young-
dc.contributor.authorNam, Sang Hoon-
dc.contributor.authorShin, Seunghang-
dc.contributor.authorChoi, Su Hyun-
dc.contributor.authorKim, Do Hyeog-
dc.contributor.authorLee, Heedoo-
dc.contributor.authorChoi, Hyeok Jae-
dc.contributor.authorLee, Eungman-
dc.contributor.authorPark, Jung Hyun-
dc.contributor.authorJo, Inho-
dc.contributor.authorFang, Nicholas X.-
dc.contributor.authorCho, Young Tae-
dc.date.accessioned2022-10-11T12:24:55Z-
dc.date.available2022-10-11T12:24:55Z-
dc.date.issued2021-
dc.identifier.citationACS Nano, 2021, v. 15, n. 9, p. 14049-14060-
dc.identifier.issn1936-0851-
dc.identifier.urihttp://hdl.handle.net/10722/318945-
dc.description.abstractEvaporation-induced particle aggregation in drying droplets is of significant importance in the prevention of pathogen transfer due to the possibility of indirect fomite transmission of the infectious virus particles. In this study, particle aggregation was directionally controlled using contact line dynamics (pinned or slipping) and geometrical gradients on microstructured surfaces by the systematic investigation of the evaporation process on sessile droplets and sprayed microdroplets laden with virus-simulant nanoparticles. Using this mechanism, we designed robust particle capture surfaces by significantly inhibiting the contact transfer of particles from fomite surfaces. For the proof-of-concept, interconnected hexagonal and inverted pyramidal microwall were fabricated using ultraviolet-based nanoimprint lithography, which is considered to be a promising scalable manufacturing process. We demonstrated the potentials of an engineered microcavity surface to limit the contact transfer of particle aggregates deposited with the evaporation of microdroplets by 93% for hexagonal microwall and by 96% for inverted pyramidal microwall. The particle capture potential of the interconnected microstructures was also investigated using biological particles, including adenoviruses and lung-derived extracellular vesicles. The findings indicate that the proposed microstructured surfaces can reduce the indirect fomite transmission of highly infectious agents, including norovirus, rotavirus, or SARS-CoV-2, via respiratory droplets.-
dc.languageeng-
dc.relation.ispartofACS Nano-
dc.subjectdirectional particle aggregation-
dc.subjectfomite transmission-
dc.subjectmicrostructured surfaces-
dc.subjectnanoparticles-
dc.subjectrespiratory droplets-
dc.subjectvirus particles-
dc.titleMicrostructured Surfaces for Reducing Chances of Fomite Transmission via Virus-Containing Respiratory Droplets-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/acsnano.1c01636-
dc.identifier.pmid34339604-
dc.identifier.scopuseid_2-s2.0-85113628514-
dc.identifier.volume15-
dc.identifier.issue9-
dc.identifier.spage14049-
dc.identifier.epage14060-
dc.identifier.eissn1936-086X-
dc.identifier.isiWOS:000703553600009-

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