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Article: Thicker Retinal Nerve Fiber Layer with Age among Schoolchildren: The Hong Kong Children Eye Study
Title | Thicker Retinal Nerve Fiber Layer with Age among Schoolchildren: The Hong Kong Children Eye Study |
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Authors | |
Issue Date | 2022 |
Citation | Diagnostics, 2022, v. 12, p. 500 How to Cite? |
Abstract | This study aims to investigate the effect of age on the peripapillary retinal nerve fiber layer (p-RNFL) thickness among schoolchildren. A total of 4034 children aged 6-8 years old received comprehensive ophthalmological examinations. p-RNFL thickness was measured from a circular scan (⌀ = 3.4 mm) captured using spectral-domain optical coherence tomography (SD-OCT). Associations between p-RNFL thickness with ocular and systemic factors were determined by multivariate linear regression after adjusting potential confounders using generalized estimating equations (GEE). The mean global p-RNFL thickness was 106.60 ± 9.41 μm (range: 72 to 171 μm) in the right eyes, 105.99 ± 9.30 μm (range: 76 to 163 μm) in the left eyes, and 106.29 ± 9.36 μm (range: 72 to 171 μm) across both eyes. Age was positively correlated with p-RNFL after adjusting for axial length (AL) and confounding factors (β = 0.509; p = 0.001). Upon multivariable analysis, AL was positively associated with temporal p-RNFL thickness (β = 3.186, p < 0.001) but negatively with non-temporal p-RNFL thickness (β = (10.003, -2.294), p < 0.001). Sectoral p-RNFL was the thickest in the inferior temporal region (155.12 ± 19.42 μm, range 68 to 271 μm), followed by the superior temporal region (154.67 ± 19.99 μm, range 32 to 177 μm). To conclude, p-RNFL increased significantly with older age among children 6 to 8 years old in a converse trend compared to adults. Our results provide a reference for interpreting OCT information in children and suggest that stable p-RNFL thickness may not indicate a stable disease status in pediatric patients due to the age effects. |
Persistent Identifier | http://hdl.handle.net/10722/320263 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Zhang, XJ | - |
dc.contributor.author | Lau, YH | - |
dc.contributor.author | Wang, YM | - |
dc.contributor.author | Chan, HN | - |
dc.contributor.author | Chan, PP | - |
dc.contributor.author | Kam, KW | - |
dc.contributor.author | Ip, P | - |
dc.contributor.author | Zhang, W | - |
dc.contributor.author | Young, AL | - |
dc.contributor.author | Tham, CC | - |
dc.contributor.author | Pang, CP | - |
dc.contributor.author | Chen, LJ | - |
dc.contributor.author | Yam, JC | - |
dc.date.accessioned | 2022-10-21T07:50:01Z | - |
dc.date.available | 2022-10-21T07:50:01Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | Diagnostics, 2022, v. 12, p. 500 | - |
dc.identifier.uri | http://hdl.handle.net/10722/320263 | - |
dc.description.abstract | This study aims to investigate the effect of age on the peripapillary retinal nerve fiber layer (p-RNFL) thickness among schoolchildren. A total of 4034 children aged 6-8 years old received comprehensive ophthalmological examinations. p-RNFL thickness was measured from a circular scan (⌀ = 3.4 mm) captured using spectral-domain optical coherence tomography (SD-OCT). Associations between p-RNFL thickness with ocular and systemic factors were determined by multivariate linear regression after adjusting potential confounders using generalized estimating equations (GEE). The mean global p-RNFL thickness was 106.60 ± 9.41 μm (range: 72 to 171 μm) in the right eyes, 105.99 ± 9.30 μm (range: 76 to 163 μm) in the left eyes, and 106.29 ± 9.36 μm (range: 72 to 171 μm) across both eyes. Age was positively correlated with p-RNFL after adjusting for axial length (AL) and confounding factors (β = 0.509; p = 0.001). Upon multivariable analysis, AL was positively associated with temporal p-RNFL thickness (β = 3.186, p < 0.001) but negatively with non-temporal p-RNFL thickness (β = (10.003, -2.294), p < 0.001). Sectoral p-RNFL was the thickest in the inferior temporal region (155.12 ± 19.42 μm, range 68 to 271 μm), followed by the superior temporal region (154.67 ± 19.99 μm, range 32 to 177 μm). To conclude, p-RNFL increased significantly with older age among children 6 to 8 years old in a converse trend compared to adults. Our results provide a reference for interpreting OCT information in children and suggest that stable p-RNFL thickness may not indicate a stable disease status in pediatric patients due to the age effects. | - |
dc.language | eng | - |
dc.relation.ispartof | Diagnostics | - |
dc.title | Thicker Retinal Nerve Fiber Layer with Age among Schoolchildren: The Hong Kong Children Eye Study | - |
dc.type | Article | - |
dc.identifier.email | Ip, P: patricip@hku.hk | - |
dc.identifier.authority | Ip, P=rp01337 | - |
dc.identifier.doi | 10.3390/diagnostics12020500 | - |
dc.identifier.hkuros | 340106 | - |
dc.identifier.volume | 12 | - |
dc.identifier.spage | 500 | - |
dc.identifier.epage | 500 | - |
dc.identifier.isi | WOS:000770896400001 | - |