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Article: Relationship between viral load and pregnancy outcomes among hepatitis B carriers

TitleRelationship between viral load and pregnancy outcomes among hepatitis B carriers
Authors
KeywordsComplications
Gestational diabetes
Hepatitis B virus
Pre-eclampsia
Pregnancy
Issue Date2022
Citation
Taiwanese Journal of Obstetrics and Gynecology, 2022, v. 61 n. 4, p. 630-633 How to Cite?
AbstractObjective: Pregnant hepatitis B carriers may have a higher risk of adverse pregnancy outcomes. Current evidences are conflicting regarding the relationship between hepatitis B virus (HBV) and various pregnancy complications, owing to the inclusion of women with different viral activity. This study is to evaluate the relationship between hepatitis B e antigen (HBeAg) status/HBV DNA level and pregnancy outcomes among pregnant hepatitis B carriers in Hong Kong. Materials and methods: This was a retrospective analysis of a prospective multicenter observational study carried out in Hong Kong between 2014 and 2016. Pregnant HBV carriers were recruited. HBeAg was tested. HBV DNA level was quantified at 28–30 weeks of gestation. The rates of gestational diabetes mellitus (GDM), gestational hypertension, pre-eclampsia, preterm prelabour rupture of membranes (PPROM), preterm birth, low birth weight (LBW), macrosomia and mode of delivery were recorded. Results: 679 pregnancies were analyzed. 23.3% of women were seropositive for HBeAg. The mean viral load (SD) at 28–30 weeks of gestation was 3.6 (2.5) log10IU/ml. No statistically significant differences were found in the rates of GDM, gestational hypertension, pre-eclampsia, PPROM, preterm birth, LBW, macrosomia and mode of delivery among women with different viral load levels (≤2 log10IU/ml, 2.01–6 log10IU/ml and >6 log10IU/ml). Positive maternal HBeAg status was not associated with pregnancy complications compared to seronegative women. Conclusion: Seropositive HBeAg status or a higher level of HBV DNA during pregnancy did not pose a significant negative impact to the pregnancy outcomes.
Persistent Identifierhttp://hdl.handle.net/10722/320323
ISSN
2023 Impact Factor: 2.0
2023 SCImago Journal Rankings: 0.632
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCheung, KW-
dc.contributor.authorWang, W-
dc.contributor.authorSo, PL-
dc.contributor.authorWong, D-
dc.contributor.authorMak, SLA-
dc.contributor.authorHui, W-
dc.contributor.authorSeto, TYM-
dc.date.accessioned2022-10-21T07:51:10Z-
dc.date.available2022-10-21T07:51:10Z-
dc.date.issued2022-
dc.identifier.citationTaiwanese Journal of Obstetrics and Gynecology, 2022, v. 61 n. 4, p. 630-633-
dc.identifier.issn1028-4559-
dc.identifier.urihttp://hdl.handle.net/10722/320323-
dc.description.abstractObjective: Pregnant hepatitis B carriers may have a higher risk of adverse pregnancy outcomes. Current evidences are conflicting regarding the relationship between hepatitis B virus (HBV) and various pregnancy complications, owing to the inclusion of women with different viral activity. This study is to evaluate the relationship between hepatitis B e antigen (HBeAg) status/HBV DNA level and pregnancy outcomes among pregnant hepatitis B carriers in Hong Kong. Materials and methods: This was a retrospective analysis of a prospective multicenter observational study carried out in Hong Kong between 2014 and 2016. Pregnant HBV carriers were recruited. HBeAg was tested. HBV DNA level was quantified at 28–30 weeks of gestation. The rates of gestational diabetes mellitus (GDM), gestational hypertension, pre-eclampsia, preterm prelabour rupture of membranes (PPROM), preterm birth, low birth weight (LBW), macrosomia and mode of delivery were recorded. Results: 679 pregnancies were analyzed. 23.3% of women were seropositive for HBeAg. The mean viral load (SD) at 28–30 weeks of gestation was 3.6 (2.5) log10IU/ml. No statistically significant differences were found in the rates of GDM, gestational hypertension, pre-eclampsia, PPROM, preterm birth, LBW, macrosomia and mode of delivery among women with different viral load levels (≤2 log10IU/ml, 2.01–6 log10IU/ml and >6 log10IU/ml). Positive maternal HBeAg status was not associated with pregnancy complications compared to seronegative women. Conclusion: Seropositive HBeAg status or a higher level of HBV DNA during pregnancy did not pose a significant negative impact to the pregnancy outcomes.-
dc.languageeng-
dc.relation.ispartofTaiwanese Journal of Obstetrics and Gynecology-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectComplications-
dc.subjectGestational diabetes-
dc.subjectHepatitis B virus-
dc.subjectPre-eclampsia-
dc.subjectPregnancy-
dc.titleRelationship between viral load and pregnancy outcomes among hepatitis B carriers-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1016/j.tjog.2021.08.006-
dc.identifier.pmid35779912-
dc.identifier.scopuseid_2-s2.0-85132358065-
dc.identifier.hkuros339829-
dc.identifier.volume61-
dc.identifier.issue4-
dc.identifier.spage630-
dc.identifier.epage633-
dc.identifier.isiWOS:000830075600014-

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