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Article: Soybean-derived Bowman-Birk inhibitor (BBI) blocks HIV entry into macrophages

TitleSoybean-derived Bowman-Birk inhibitor (BBI) blocks HIV entry into macrophages
Authors
KeywordsBowman-Birk inhibitor
CC chemokine
CCR5
CD4
HIV
Issue Date2018
Citation
Virology, 2018, v. 513, p. 91-97 How to Cite?
AbstractBowman-Birk inhibitor (BBI) is a soybean-derived protease inhibitor that has anti-inflammation and anti-HIV effect. Here, we further investigated the anti-HIV action of BBI in macrophages, focusing on its effect on viral entry. We found that BBI could significantly block HIV entry into macrophages. Investigation of the mechanism(s) of the BBI action on HIV inhibition showed that BBI down-regulated the expression of CD4 receptor (as much as 80%) and induced the production of the CC chemokines (up to 60 folds at protein level) in macrophages. This inhibitory effect of BBI on HIV entry could be blocked by the neutralization antibodies to CC chemokines. These findings indicate that BBI may have therapeutic potential as a viral entry inhibitor for the prevention and treatment of HIV infection.
Persistent Identifierhttp://hdl.handle.net/10722/321757
ISSN
2021 Impact Factor: 3.513
2020 SCImago Journal Rankings: 1.389

 

DC FieldValueLanguage
dc.contributor.authorMa, Tong Cui-
dc.contributor.authorGuo, Le-
dc.contributor.authorZhou, Run Hong-
dc.contributor.authorWang, Xu-
dc.contributor.authorLiu, Jin Biao-
dc.contributor.authorLi, Jie Liang-
dc.contributor.authorZhou, Yu-
dc.contributor.authorHou, Wei-
dc.contributor.authorHo, Wen Zhe-
dc.date.accessioned2022-11-03T02:21:14Z-
dc.date.available2022-11-03T02:21:14Z-
dc.date.issued2018-
dc.identifier.citationVirology, 2018, v. 513, p. 91-97-
dc.identifier.issn0042-6822-
dc.identifier.urihttp://hdl.handle.net/10722/321757-
dc.description.abstractBowman-Birk inhibitor (BBI) is a soybean-derived protease inhibitor that has anti-inflammation and anti-HIV effect. Here, we further investigated the anti-HIV action of BBI in macrophages, focusing on its effect on viral entry. We found that BBI could significantly block HIV entry into macrophages. Investigation of the mechanism(s) of the BBI action on HIV inhibition showed that BBI down-regulated the expression of CD4 receptor (as much as 80%) and induced the production of the CC chemokines (up to 60 folds at protein level) in macrophages. This inhibitory effect of BBI on HIV entry could be blocked by the neutralization antibodies to CC chemokines. These findings indicate that BBI may have therapeutic potential as a viral entry inhibitor for the prevention and treatment of HIV infection.-
dc.languageeng-
dc.relation.ispartofVirology-
dc.subjectBowman-Birk inhibitor-
dc.subjectCC chemokine-
dc.subjectCCR5-
dc.subjectCD4-
dc.subjectHIV-
dc.titleSoybean-derived Bowman-Birk inhibitor (BBI) blocks HIV entry into macrophages-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.virol.2017.08.030-
dc.identifier.pmid29040829-
dc.identifier.scopuseid_2-s2.0-85031793968-
dc.identifier.volume513-
dc.identifier.spage91-
dc.identifier.epage97-
dc.identifier.eissn1096-0341-

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