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Article: Novel 3D printed alginate–BFP1 hybrid scaffolds for enhanced bone regeneration

TitleNovel 3D printed alginate–BFP1 hybrid scaffolds for enhanced bone regeneration
Authors
Heo, Eun YoungKo, Na ReBae, Min SooLee, Sang JinChoi, Byung JoonKim, Jung HoKim, Hyung KeunPark, Su A.Kwon, Il Keun
Keywords3D printing
BFP1
Bone regeneration
Hydrogel scaffold
Tissue engineering
Issue Date2017
Citation
Journal of Industrial and Engineering Chemistry, 2017, v. 45, p. 61-67 How to Cite?
DOI: http://dx.doi.org/10.1016/j.jiec.2016.09.003
AbstractIn this research, novel 3D printed alginate–peptide hybrid scaffolds were explored for enhanced bone regeneration. Bone formation peptide-1 (BFP1) was loaded into the scaffolds to promote bone regeneration. The alginate–BFP1 conjugates were synthesized via a facile EDC/NHS coupling reaction and then cross-linked in the presence of calcium ions to form hydrogel networks. The dose-dependent cytotoxicity of CaCl2 was evaluated to optimize the amount of Ca2+ for fabrication of scaffolds. In vitro and in vivo studies indicated that the alginate-based scaffolds provided a stable environment for the growth of human adipose-derived stem cells (hADSCs) and led to a synergistically enhanced bone regeneration.
Persistent Identifierhttp://hdl.handle.net/10722/323998
ISSN
1226-086X
2021 Impact Factor: 6.760
2020 SCImago Journal Rankings: 1.103

 

DC FieldValueLanguage
dc.contributor.authorHeo, Eun Young-
dc.contributor.authorKo, Na Re-
dc.contributor.authorBae, Min Soo-
dc.contributor.authorLee, Sang Jin-
dc.contributor.authorChoi, Byung Joon-
dc.contributor.authorKim, Jung Ho-
dc.contributor.authorKim, Hyung Keun-
dc.contributor.authorPark, Su A.-
dc.contributor.authorKwon, Il Keun-
dc.date.accessioned2023-01-13T03:00:47Z-
dc.date.available2023-01-13T03:00:47Z-
dc.date.issued2017-
dc.identifier.citationJournal of Industrial and Engineering Chemistry, 2017, v. 45, p. 61-67-
dc.identifier.issn1226-086X-
dc.identifier.urihttp://hdl.handle.net/10722/323998-
dc.description.abstractIn this research, novel 3D printed alginate–peptide hybrid scaffolds were explored for enhanced bone regeneration. Bone formation peptide-1 (BFP1) was loaded into the scaffolds to promote bone regeneration. The alginate–BFP1 conjugates were synthesized via a facile EDC/NHS coupling reaction and then cross-linked in the presence of calcium ions to form hydrogel networks. The dose-dependent cytotoxicity of CaCl2 was evaluated to optimize the amount of Ca2+ for fabrication of scaffolds. In vitro and in vivo studies indicated that the alginate-based scaffolds provided a stable environment for the growth of human adipose-derived stem cells (hADSCs) and led to a synergistically enhanced bone regeneration.-
dc.languageeng-
dc.relation.ispartofJournal of Industrial and Engineering Chemistry-
dc.subject3D printing-
dc.subjectBFP1-
dc.subjectBone regeneration-
dc.subjectHydrogel scaffold-
dc.subjectTissue engineering-
dc.titleNovel 3D printed alginate–BFP1 hybrid scaffolds for enhanced bone regeneration-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jiec.2016.09.003-
dc.identifier.scopuseid_2-s2.0-84998953506-
dc.identifier.volume45-
dc.identifier.spage61-
dc.identifier.epage67-
dc.identifier.eissn2234-5957-

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