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- Publisher Website: 10.1016/j.envpol.2018.04.123
- Scopus: eid_2-s2.0-85048186400
- PMID: 29753251
- WOS: WOS:000438322100046
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Article: Long-term exposure to ambient particulate matter (PM2.5 ) is associated with platelet counts in adults
Title | Long-term exposure to ambient particulate matter (PM<inf>2.5</inf>) is associated with platelet counts in adults |
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Authors | |
Keywords | Blood coagulability Particulate matter Platelet count |
Issue Date | 2018 |
Citation | Environmental Pollution, 2018, v. 240, p. 432-439 How to Cite? |
Abstract | Background: The prothrombotic effects of particulate matter (PM) may underlie the association of air pollution with increased risks of cardiovascular disease. This study aimed to investigate the association between long-term exposure to PM with an aerodynamic diameter ≤2.5 μm (PM2.5) and platelet counts, a marker of coagulation profiles. Methods: The study participants were from a cohort consisting of 362,396 Taiwanese adults who participated in a standard medical examination program between 2001 and 2014. Platelet counts were measured through Complete Blood Count tests. A satellite-based spatio-temporal model was used to estimate 2-year average ambient PM2.5 concentration at each participant's address. Mixed-effects linear regression models were used to investigate the association between PM2.5 exposure and platelet counts. Results: This analysis included 175,959 men with 396,248 observations and 186,437 women with 397,877 observations. Every 10-μg/m3 increment in the 2-year average PM2.5 was associated with increases of 0.42% (95% CI: 0.38%, 0.47%) and 0.49% (95% CI: 0.44%, 0.54%) in platelet counts in men and women, respectively. A series of sensitivity analyses, including an analysis in participants free of cardiometabolic disorders, confirmed the robustness of the observed associations. Baseline data analyses showed that every 10-μg/m3 increment in PM2.5 was associated with higher risk of 17% and 14% of having elevated platelet counts (≥90th percentile) in men and women, respectively. Conclusions: Long-term exposure to PM2.5 appears to be associated with increased platelet counts, indicating potential adverse effects on blood coagulability. |
Persistent Identifier | http://hdl.handle.net/10722/324052 |
ISSN | 2023 Impact Factor: 7.6 2023 SCImago Journal Rankings: 2.132 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Zhang, Zilong | - |
dc.contributor.author | Chan, Ta Chien | - |
dc.contributor.author | Guo, Cui | - |
dc.contributor.author | Chang, Ly yun | - |
dc.contributor.author | Lin, Changqing | - |
dc.contributor.author | Chuang, Yuan Chieh | - |
dc.contributor.author | Jiang, Wun Kai | - |
dc.contributor.author | Ho, Kin Fai | - |
dc.contributor.author | Tam, Tony | - |
dc.contributor.author | Woo, Kam S. | - |
dc.contributor.author | Lau, Alexis K.H. | - |
dc.contributor.author | Lao, Xiang Qian | - |
dc.date.accessioned | 2023-01-13T03:01:09Z | - |
dc.date.available | 2023-01-13T03:01:09Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Environmental Pollution, 2018, v. 240, p. 432-439 | - |
dc.identifier.issn | 0269-7491 | - |
dc.identifier.uri | http://hdl.handle.net/10722/324052 | - |
dc.description.abstract | Background: The prothrombotic effects of particulate matter (PM) may underlie the association of air pollution with increased risks of cardiovascular disease. This study aimed to investigate the association between long-term exposure to PM with an aerodynamic diameter ≤2.5 μm (PM2.5) and platelet counts, a marker of coagulation profiles. Methods: The study participants were from a cohort consisting of 362,396 Taiwanese adults who participated in a standard medical examination program between 2001 and 2014. Platelet counts were measured through Complete Blood Count tests. A satellite-based spatio-temporal model was used to estimate 2-year average ambient PM2.5 concentration at each participant's address. Mixed-effects linear regression models were used to investigate the association between PM2.5 exposure and platelet counts. Results: This analysis included 175,959 men with 396,248 observations and 186,437 women with 397,877 observations. Every 10-μg/m3 increment in the 2-year average PM2.5 was associated with increases of 0.42% (95% CI: 0.38%, 0.47%) and 0.49% (95% CI: 0.44%, 0.54%) in platelet counts in men and women, respectively. A series of sensitivity analyses, including an analysis in participants free of cardiometabolic disorders, confirmed the robustness of the observed associations. Baseline data analyses showed that every 10-μg/m3 increment in PM2.5 was associated with higher risk of 17% and 14% of having elevated platelet counts (≥90th percentile) in men and women, respectively. Conclusions: Long-term exposure to PM2.5 appears to be associated with increased platelet counts, indicating potential adverse effects on blood coagulability. | - |
dc.language | eng | - |
dc.relation.ispartof | Environmental Pollution | - |
dc.subject | Blood coagulability | - |
dc.subject | Particulate matter | - |
dc.subject | Platelet count | - |
dc.title | Long-term exposure to ambient particulate matter (PM<inf>2.5</inf>) is associated with platelet counts in adults | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.envpol.2018.04.123 | - |
dc.identifier.pmid | 29753251 | - |
dc.identifier.scopus | eid_2-s2.0-85048186400 | - |
dc.identifier.volume | 240 | - |
dc.identifier.spage | 432 | - |
dc.identifier.epage | 439 | - |
dc.identifier.eissn | 1873-6424 | - |
dc.identifier.isi | WOS:000438322100046 | - |