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Article: Long-term exposure to ambient fine particles and gastrointestinal cancer mortality in Taiwan: A cohort study

TitleLong-term exposure to ambient fine particles and gastrointestinal cancer mortality in Taiwan: A cohort study
Authors
KeywordsGastrointestinal cancer mortality
Live cancer mortality
Long-term exposure
PM air pollution 2.5
Taiwan
Issue Date2020
Citation
Environment International, 2020, v. 138, article no. 105640 How to Cite?
AbstractBackground: Information on the association between long-term exposure to PM2.5 and gastrointestinal cancer mortality is scarce. Objectives: This study investigated the association between long-term exposure to PM2.5 and deaths from gastrointestinal cancer and its subtypes in adults in Taiwan. Methods: A total of 385,650 Taiwanese adults (≥18 years old) jointed a standard medical examination program between 2001 and 2014 and were followed up until 2016. Their vital data were obtained from the National Death Registry maintained by the Ministry of Health and Welfare in Taiwan. We estimated the ambient PM2.5 concentration at individual's address utilising a satellite-based spatiotemporal model at a resolution of 1 km2. Cox proportional hazard regression model was used to investigate the associations between ambient PM2.5 and deaths from gastrointestinal, stomach, colorectal and liver cancers. Results: We found that each 10 µg/m3 increase in PM2.5 was associated with an increased hazard risk (HR) of 1.09 (95% confidence interval (CI): 1.03–1.16) and 1.13 (95%CI: 1.02–1.24) in deaths from gastrointestinal and liver cancers, respectively. The association between PM2.5 and death from colorectal cancer was marginally statistically significant [HR: 1.13 (95%CI: 1.00–1.26)]. We did not find significant associations between PM2.5 and mortality from stomach cancer. Conclusions: Long-term exposure to ambient PM2.5 was associated with an increased risk of deaths from gastrointestinal cancers, liver cancer and also potentially colorectal cancer. Air pollution control strategies are necessary to reduce the burden of gastrointestinal cancer.
Persistent Identifierhttp://hdl.handle.net/10722/324120
ISSN
2023 Impact Factor: 10.3
2023 SCImago Journal Rankings: 3.015
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorGuo, Cui-
dc.contributor.authorChan, Ta Chien-
dc.contributor.authorTeng, Yung Chu-
dc.contributor.authorLin, Changqing-
dc.contributor.authorBo, Yacong-
dc.contributor.authorChang, Ly yun-
dc.contributor.authorLau, Alexis K.H.-
dc.contributor.authorTam, Tony-
dc.contributor.authorWong, Martin C.S.-
dc.contributor.authorQian Lao, Xiang-
dc.date.accessioned2023-01-13T03:01:38Z-
dc.date.available2023-01-13T03:01:38Z-
dc.date.issued2020-
dc.identifier.citationEnvironment International, 2020, v. 138, article no. 105640-
dc.identifier.issn0160-4120-
dc.identifier.urihttp://hdl.handle.net/10722/324120-
dc.description.abstractBackground: Information on the association between long-term exposure to PM2.5 and gastrointestinal cancer mortality is scarce. Objectives: This study investigated the association between long-term exposure to PM2.5 and deaths from gastrointestinal cancer and its subtypes in adults in Taiwan. Methods: A total of 385,650 Taiwanese adults (≥18 years old) jointed a standard medical examination program between 2001 and 2014 and were followed up until 2016. Their vital data were obtained from the National Death Registry maintained by the Ministry of Health and Welfare in Taiwan. We estimated the ambient PM2.5 concentration at individual's address utilising a satellite-based spatiotemporal model at a resolution of 1 km2. Cox proportional hazard regression model was used to investigate the associations between ambient PM2.5 and deaths from gastrointestinal, stomach, colorectal and liver cancers. Results: We found that each 10 µg/m3 increase in PM2.5 was associated with an increased hazard risk (HR) of 1.09 (95% confidence interval (CI): 1.03–1.16) and 1.13 (95%CI: 1.02–1.24) in deaths from gastrointestinal and liver cancers, respectively. The association between PM2.5 and death from colorectal cancer was marginally statistically significant [HR: 1.13 (95%CI: 1.00–1.26)]. We did not find significant associations between PM2.5 and mortality from stomach cancer. Conclusions: Long-term exposure to ambient PM2.5 was associated with an increased risk of deaths from gastrointestinal cancers, liver cancer and also potentially colorectal cancer. Air pollution control strategies are necessary to reduce the burden of gastrointestinal cancer.-
dc.languageeng-
dc.relation.ispartofEnvironment International-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectGastrointestinal cancer mortality-
dc.subjectLive cancer mortality-
dc.subjectLong-term exposure-
dc.subjectPM air pollution 2.5-
dc.subjectTaiwan-
dc.titleLong-term exposure to ambient fine particles and gastrointestinal cancer mortality in Taiwan: A cohort study-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1016/j.envint.2020.105640-
dc.identifier.pmid32179321-
dc.identifier.scopuseid_2-s2.0-85081228276-
dc.identifier.volume138-
dc.identifier.spagearticle no. 105640-
dc.identifier.epagearticle no. 105640-
dc.identifier.eissn1873-6750-
dc.identifier.isiWOS:000522749900046-

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