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Article: Reprogramming transcription after DNA damage: recognition, response, repair, and restart

TitleReprogramming transcription after DNA damage: recognition, response, repair, and restart
Authors
KeywordsDNA damage response
DNA damage-induced transcriptional silencing
RNA Pol II
transcription restart after DNA damage
transcription-coupled DNA repair
Issue Date2022
Citation
Trends in Cell Biology, 2022 How to Cite?
AbstractGenome integrity is constantly challenged by endogenous and exogenous insults that cause DNA damage. To cope with these threats, cells have a surveillance mechanism, known as the DNA damage response (DDR), to repair any lesions. Although transcription has long been implicated in DNA repair, how transcriptional reprogramming is coordinated with the DDR is just beginning to be understood. In this review, we highlight recent advances in elucidating the molecular mechanisms underlying major transcriptional events, including RNA polymerase (Pol) II stalling and transcriptional silencing and recovery, which occur in response to DNA damage. Furthermore, we discuss how such transcriptional adaptation contributes to sensing and eliminating damaged DNA and how it can jeopardize genome integrity when it goes awry.
Persistent Identifierhttp://hdl.handle.net/10722/324240
ISSN
2023 Impact Factor: 13.0
2023 SCImago Journal Rankings: 6.002
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLu, Huasong-
dc.contributor.authorYang, Min-
dc.contributor.authorZhou, Qiang-
dc.date.accessioned2023-01-13T03:02:27Z-
dc.date.available2023-01-13T03:02:27Z-
dc.date.issued2022-
dc.identifier.citationTrends in Cell Biology, 2022-
dc.identifier.issn0962-8924-
dc.identifier.urihttp://hdl.handle.net/10722/324240-
dc.description.abstractGenome integrity is constantly challenged by endogenous and exogenous insults that cause DNA damage. To cope with these threats, cells have a surveillance mechanism, known as the DNA damage response (DDR), to repair any lesions. Although transcription has long been implicated in DNA repair, how transcriptional reprogramming is coordinated with the DDR is just beginning to be understood. In this review, we highlight recent advances in elucidating the molecular mechanisms underlying major transcriptional events, including RNA polymerase (Pol) II stalling and transcriptional silencing and recovery, which occur in response to DNA damage. Furthermore, we discuss how such transcriptional adaptation contributes to sensing and eliminating damaged DNA and how it can jeopardize genome integrity when it goes awry.-
dc.languageeng-
dc.relation.ispartofTrends in Cell Biology-
dc.subjectDNA damage response-
dc.subjectDNA damage-induced transcriptional silencing-
dc.subjectRNA Pol II-
dc.subjecttranscription restart after DNA damage-
dc.subjecttranscription-coupled DNA repair-
dc.titleReprogramming transcription after DNA damage: recognition, response, repair, and restart-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.tcb.2022.11.010-
dc.identifier.pmid36513571-
dc.identifier.scopuseid_2-s2.0-85145194849-
dc.identifier.eissn1879-3088-
dc.identifier.isiWOS:001047800000001-

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