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Article: Association between proto-oncoprotein Rel and TATA-binding protein mediates transcriptional activation by NF-κB

TitleAssociation between proto-oncoprotein Rel and TATA-binding protein mediates transcriptional activation by NF-κB
Authors
Kerr, Lawrence D.Ransone, Lynn J.Wamsley, PennySchmitt, Mark J.Boyer, Thomas G.Zhou, QiangBerk, Arnold J.Verma, Inder M.
Issue Date1993
Citation
Nature, 1993, v. 365, n. 6445, p. 412-419 How to Cite?
DOI: http://dx.doi.org/10.1038/365412a0
AbstractThe c-Rel protein is able to associate in vitro and in vivo with the TATA-binding protein (TBP) of the TFIID complex. Coexpression of TBP with c-Rel augments transactivation from the κB site in Drosophila Schneider cells. DNA-binding mutants of TBP not only fail to cooperate, but they repress transactivation by c-Rel. There may be a direct communication between κB enhancer binding proteins and basal transcription factors which leads to enhanced transcription. © 1993 Nature Publishing Group.
Persistent Identifierhttp://hdl.handle.net/10722/324981
ISSN
0028-0836
2023 Impact Factor: 50.5
2023 SCImago Journal Rankings: 18.509
ISI Accession Number ID
WOS:A1993LZ63300047

 

DC FieldValueLanguage
dc.contributor.authorKerr, Lawrence D.-
dc.contributor.authorRansone, Lynn J.-
dc.contributor.authorWamsley, Penny-
dc.contributor.authorSchmitt, Mark J.-
dc.contributor.authorBoyer, Thomas G.-
dc.contributor.authorZhou, Qiang-
dc.contributor.authorBerk, Arnold J.-
dc.contributor.authorVerma, Inder M.-
dc.date.accessioned2023-02-27T07:28:43Z-
dc.date.available2023-02-27T07:28:43Z-
dc.date.issued1993-
dc.identifier.citationNature, 1993, v. 365, n. 6445, p. 412-419-
dc.identifier.issn0028-0836-
dc.identifier.urihttp://hdl.handle.net/10722/324981-
dc.description.abstractThe c-Rel protein is able to associate in vitro and in vivo with the TATA-binding protein (TBP) of the TFIID complex. Coexpression of TBP with c-Rel augments transactivation from the κB site in Drosophila Schneider cells. DNA-binding mutants of TBP not only fail to cooperate, but they repress transactivation by c-Rel. There may be a direct communication between κB enhancer binding proteins and basal transcription factors which leads to enhanced transcription. © 1993 Nature Publishing Group.-
dc.languageeng-
dc.relation.ispartofNature-
dc.titleAssociation between proto-oncoprotein Rel and TATA-binding protein mediates transcriptional activation by NF-κB-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/365412a0-
dc.identifier.pmid8413585-
dc.identifier.scopuseid_2-s2.0-0027454228-
dc.identifier.volume365-
dc.identifier.issue6445-
dc.identifier.spage412-
dc.identifier.epage419-
dc.identifier.isiWOS:A1993LZ63300047-

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