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- Publisher Website: 10.1016/j.jocn.2007.03.011
- Scopus: eid_2-s2.0-43049089107
- PMID: 18342513
- WOS: WOS:000256065700010
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Article: Use of ventricular cerebrospinal fluid lactate measurement to diagnose cerebrospinal fluid infection in patients with intraventricular haemorrhage
Title | Use of ventricular cerebrospinal fluid lactate measurement to diagnose cerebrospinal fluid infection in patients with intraventricular haemorrhage |
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Authors | |
Keywords | Cerebrospinal fluid Intraventricular haemorrhage Lactate Subarachnoid haemorrhage Ventriculitis |
Issue Date | 2008 |
Citation | Journal of Clinical Neuroscience, 2008, v. 15, n. 6, p. 654-655 How to Cite? |
Abstract | Early diagnosis of ventriculostomy-associated cerebrospinal fluid (CSF) infection in acute neurosurgical patients can be difficult. The use of prophylactic antibiotics in intraventricular or subarachnoid haemorrhage decreases the sensitivity of cell counts, Gram staining and bacterial culture as diagnostic tools. We prospectively collected clinical and cerebrospinal data for 16 patients with intraventricular haemorrhage, with an external ventricular drain inserted, with or without spontaneous subarachnoid haemorrhage. Three (18.8%) patients had cerebrospinal fluid infection, with appropriate changes in antibiotic regimens needed. All three patients had CSF lactate levels of >4 mmol/L (6.4 mmol/L, 7.8 mmol/L, 7.9 mmol/L). Eleven out of 13 patients without CSF infection had CSF lactate levels of below 4 mmol/L. The two patients with CSF lactate levels of 4-6 mmol/L were grade 5 subarachnoid haemorrhage patients, one with renal impairment. Using a cut-off lactate level of 4 mmol/L, the positive predictive value was 60% and negative predictive value was 100% for CSF infection. A CSF lactate level of above 4 mmol/L should prompt suspicion of CSF infection in intraventricular haemorrhage patients with an external ventricular drain. © 2007 Elsevier Ltd. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/325163 |
ISSN | 2023 Impact Factor: 1.9 2023 SCImago Journal Rankings: 0.609 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Wong, G. K. | - |
dc.contributor.author | Poon, W. S. | - |
dc.contributor.author | Ip, M. | - |
dc.date.accessioned | 2023-02-27T07:30:15Z | - |
dc.date.available | 2023-02-27T07:30:15Z | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | Journal of Clinical Neuroscience, 2008, v. 15, n. 6, p. 654-655 | - |
dc.identifier.issn | 0967-5868 | - |
dc.identifier.uri | http://hdl.handle.net/10722/325163 | - |
dc.description.abstract | Early diagnosis of ventriculostomy-associated cerebrospinal fluid (CSF) infection in acute neurosurgical patients can be difficult. The use of prophylactic antibiotics in intraventricular or subarachnoid haemorrhage decreases the sensitivity of cell counts, Gram staining and bacterial culture as diagnostic tools. We prospectively collected clinical and cerebrospinal data for 16 patients with intraventricular haemorrhage, with an external ventricular drain inserted, with or without spontaneous subarachnoid haemorrhage. Three (18.8%) patients had cerebrospinal fluid infection, with appropriate changes in antibiotic regimens needed. All three patients had CSF lactate levels of >4 mmol/L (6.4 mmol/L, 7.8 mmol/L, 7.9 mmol/L). Eleven out of 13 patients without CSF infection had CSF lactate levels of below 4 mmol/L. The two patients with CSF lactate levels of 4-6 mmol/L were grade 5 subarachnoid haemorrhage patients, one with renal impairment. Using a cut-off lactate level of 4 mmol/L, the positive predictive value was 60% and negative predictive value was 100% for CSF infection. A CSF lactate level of above 4 mmol/L should prompt suspicion of CSF infection in intraventricular haemorrhage patients with an external ventricular drain. © 2007 Elsevier Ltd. All rights reserved. | - |
dc.language | eng | - |
dc.relation.ispartof | Journal of Clinical Neuroscience | - |
dc.subject | Cerebrospinal fluid | - |
dc.subject | Intraventricular haemorrhage | - |
dc.subject | Lactate | - |
dc.subject | Subarachnoid haemorrhage | - |
dc.subject | Ventriculitis | - |
dc.title | Use of ventricular cerebrospinal fluid lactate measurement to diagnose cerebrospinal fluid infection in patients with intraventricular haemorrhage | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.jocn.2007.03.011 | - |
dc.identifier.pmid | 18342513 | - |
dc.identifier.scopus | eid_2-s2.0-43049089107 | - |
dc.identifier.volume | 15 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | 654 | - |
dc.identifier.epage | 655 | - |
dc.identifier.isi | WOS:000256065700010 | - |