File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Management outcome of NPC-related and non-NPC-related brain abscess in Hong Kong

TitleManagement outcome of NPC-related and non-NPC-related brain abscess in Hong Kong
Authors
KeywordsBrain abscess
Drainage
Infection
Nasopharyngeal carcinoma
Radiation necrosis
Issue Date2012
Citation
Clinical Neurology and Neurosurgery, 2012, v. 114, n. 6, p. 560-563 How to Cite?
AbstractObjectives: (1) To review the patient profile, management outcome and prognostic factors of brain abscess; (2) To compare the neurological outcome of nasopharyngeal carcinoma (NPC)-related brain abscess with non-NPC related brain abscess. Method: Retrospective review of consecutive patients diagnosed (radiologically and/or microbiologically) with brain abscess in a regional neurosurgical center in Hong Kong over a nine year period. Results: Fifty-four patients were recruited into this study. There were 37 male and 17 female patients. Eighteen (33%) patients had previous radiotherapy for nasopharyngeal carcinoma. Only 31 (57%) patients had fever on presentation. White cell count and/or C-reactive protein, was raised in 41 (76%) patients on admission. Surgical drainage was carried out in 49 (91%) patients, either by aspiration through a craniotomy, by drainage with corticotomy, or excision of the abscess. Abscess culture was positive in 45 (83%) patients. Common organisms isolated included Streptococcus species (35%) and Peptostreptococcus species (18%). Anaerobes were isolated in 50% of the NPC-related abscesses. The mean follow-up time was 34 months. At the 6 months interval, 24 (44%) patients had good recovery. Favorable outcome was achieved in 30 (55%) patients. NPC-related brain abscess was associated with unfavorable neurological outcome (33%, p = 0.04). There was also a trend towards higher in-patient mortality in patients with NPC-related brain abscess (22%, p = 0.08). Conclusion: Brain abscess carried a substantial morbidity and mortality despite aggressive surgical and medical treatment. Patients with NPC-related brain abscess had a higher mortality and unfavorable neurological outcome. © 2011 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/325234
ISSN
2023 Impact Factor: 1.8
2023 SCImago Journal Rankings: 0.608
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTam, Mandy Ho Man-
dc.contributor.authorWong, George Kwok Chu-
dc.contributor.authorIp, Margaret-
dc.contributor.authorKam, Michael Koon Ming-
dc.contributor.authorAbrigo, Jill Morales-
dc.contributor.authorZhu, Xian Lun-
dc.contributor.authorPoon, Wai Sang-
dc.date.accessioned2023-02-27T07:30:51Z-
dc.date.available2023-02-27T07:30:51Z-
dc.date.issued2012-
dc.identifier.citationClinical Neurology and Neurosurgery, 2012, v. 114, n. 6, p. 560-563-
dc.identifier.issn0303-8467-
dc.identifier.urihttp://hdl.handle.net/10722/325234-
dc.description.abstractObjectives: (1) To review the patient profile, management outcome and prognostic factors of brain abscess; (2) To compare the neurological outcome of nasopharyngeal carcinoma (NPC)-related brain abscess with non-NPC related brain abscess. Method: Retrospective review of consecutive patients diagnosed (radiologically and/or microbiologically) with brain abscess in a regional neurosurgical center in Hong Kong over a nine year period. Results: Fifty-four patients were recruited into this study. There were 37 male and 17 female patients. Eighteen (33%) patients had previous radiotherapy for nasopharyngeal carcinoma. Only 31 (57%) patients had fever on presentation. White cell count and/or C-reactive protein, was raised in 41 (76%) patients on admission. Surgical drainage was carried out in 49 (91%) patients, either by aspiration through a craniotomy, by drainage with corticotomy, or excision of the abscess. Abscess culture was positive in 45 (83%) patients. Common organisms isolated included Streptococcus species (35%) and Peptostreptococcus species (18%). Anaerobes were isolated in 50% of the NPC-related abscesses. The mean follow-up time was 34 months. At the 6 months interval, 24 (44%) patients had good recovery. Favorable outcome was achieved in 30 (55%) patients. NPC-related brain abscess was associated with unfavorable neurological outcome (33%, p = 0.04). There was also a trend towards higher in-patient mortality in patients with NPC-related brain abscess (22%, p = 0.08). Conclusion: Brain abscess carried a substantial morbidity and mortality despite aggressive surgical and medical treatment. Patients with NPC-related brain abscess had a higher mortality and unfavorable neurological outcome. © 2011 Elsevier B.V. All rights reserved.-
dc.languageeng-
dc.relation.ispartofClinical Neurology and Neurosurgery-
dc.subjectBrain abscess-
dc.subjectDrainage-
dc.subjectInfection-
dc.subjectNasopharyngeal carcinoma-
dc.subjectRadiation necrosis-
dc.titleManagement outcome of NPC-related and non-NPC-related brain abscess in Hong Kong-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.clineuro.2011.11.028-
dc.identifier.scopuseid_2-s2.0-84862022410-
dc.identifier.volume114-
dc.identifier.issue6-
dc.identifier.spage560-
dc.identifier.epage563-
dc.identifier.eissn1872-6968-
dc.identifier.isiWOS:000306044900007-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats