File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Scaffold protein Homer 1: Implications for neurological diseases

TitleScaffold protein Homer 1: Implications for neurological diseases
Authors
KeywordsAddiction
Fragile X syndrome
Homer protein
Metabotropic glutamate receptor
Neuropathic pain
Postsynaptic density
Schizophrenia
Transient receptor potential channel
Traumatic brain injury
X-linked mental retardation
Issue Date2012
Citation
Neurochemistry International, 2012, v. 61, n. 5, p. 731-738 How to Cite?
AbstractHomer proteins are commonly known as scaffold proteins at postsynaptic density. Homer 1 is a widely studied member of the Homer protein family, comprising both synaptic structure and mediating postsynaptic signaling transduction. Both an immediate-early gene encoding a Homer 1 variant and a constitutively expressed Homer 1 variant regulate receptor clustering and trafficking, intracellular calcium homeostasis, and intracellular molecule complex formation. Substantial preclinical investigations have implicated that each of these Homer 1 variants are associated with the etiology of many neurological diseases, such as pain, mental retardation syndromes, Alzheimer's disease, schizophrenia, drug-induced addiction, and traumatic brain injury. © 2012 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/325249
ISSN
2023 Impact Factor: 4.4
2023 SCImago Journal Rankings: 1.049
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLuo, Peng-
dc.contributor.authorLi, Xia-
dc.contributor.authorFei, Zhou-
dc.contributor.authorPoon, Waisang-
dc.date.accessioned2023-02-27T07:30:57Z-
dc.date.available2023-02-27T07:30:57Z-
dc.date.issued2012-
dc.identifier.citationNeurochemistry International, 2012, v. 61, n. 5, p. 731-738-
dc.identifier.issn0197-0186-
dc.identifier.urihttp://hdl.handle.net/10722/325249-
dc.description.abstractHomer proteins are commonly known as scaffold proteins at postsynaptic density. Homer 1 is a widely studied member of the Homer protein family, comprising both synaptic structure and mediating postsynaptic signaling transduction. Both an immediate-early gene encoding a Homer 1 variant and a constitutively expressed Homer 1 variant regulate receptor clustering and trafficking, intracellular calcium homeostasis, and intracellular molecule complex formation. Substantial preclinical investigations have implicated that each of these Homer 1 variants are associated with the etiology of many neurological diseases, such as pain, mental retardation syndromes, Alzheimer's disease, schizophrenia, drug-induced addiction, and traumatic brain injury. © 2012 Elsevier Ltd. All rights reserved.-
dc.languageeng-
dc.relation.ispartofNeurochemistry International-
dc.subjectAddiction-
dc.subjectFragile X syndrome-
dc.subjectHomer protein-
dc.subjectMetabotropic glutamate receptor-
dc.subjectNeuropathic pain-
dc.subjectPostsynaptic density-
dc.subjectSchizophrenia-
dc.subjectTransient receptor potential channel-
dc.subjectTraumatic brain injury-
dc.subjectX-linked mental retardation-
dc.titleScaffold protein Homer 1: Implications for neurological diseases-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.neuint.2012.06.014-
dc.identifier.pmid22749857-
dc.identifier.scopuseid_2-s2.0-84867494020-
dc.identifier.volume61-
dc.identifier.issue5-
dc.identifier.spage731-
dc.identifier.epage738-
dc.identifier.eissn1872-9754-
dc.identifier.isiWOS:000310946100014-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats