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Article: Transcriptional and epigenetic regulation of human microRNAs

TitleTranscriptional and epigenetic regulation of human microRNAs
Authors
Wang, ZifengYao, HongLin, ShengZhu, XiaoShen, ZanLu, GangPoon, Wai SangXie, DanLin, Marie Chia MiKung, Hsiang Fu
KeywordsCancer
Epigenetic regulation
MiRNA
Transcription machinery
Transcriptional regulation
Issue Date2013
Citation
Cancer Letters, 2013, v. 331, n. 1, p. 1-10 How to Cite?
DOI: http://dx.doi.org/10.1016/j.canlet.2012.12.006
AbstractMicroRNAs (miRNAs) are members of non-coding RNAs. They are involved in diverse biological functions. MiRNAs are precisely regulated in a tissue- and developmental-specific manner, but dysregulated in many human diseases, in particular cancers. Transcriptional regulation, post-transcriptional regulation, as well as genetic alterations, are the three major mechanisms controlling the spatial and temporal expression of miRNAs. Emerging evidence now indicates that transcriptional and epigenetic regulations play major roles in miRNA expression. This review summarizes the current knowledge and discusses the future challenges. © 2012 Elsevier Ireland Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/325258
ISSN
0304-3835
2023 Impact Factor: 9.1
2023 SCImago Journal Rankings: 2.595
ISI Accession Number ID
WOS:000315610100001

 

DC FieldValueLanguage
dc.contributor.authorWang, Zifeng-
dc.contributor.authorYao, Hong-
dc.contributor.authorLin, Sheng-
dc.contributor.authorZhu, Xiao-
dc.contributor.authorShen, Zan-
dc.contributor.authorLu, Gang-
dc.contributor.authorPoon, Wai Sang-
dc.contributor.authorXie, Dan-
dc.contributor.authorLin, Marie Chia Mi-
dc.contributor.authorKung, Hsiang Fu-
dc.date.accessioned2023-02-27T07:31:01Z-
dc.date.available2023-02-27T07:31:01Z-
dc.date.issued2013-
dc.identifier.citationCancer Letters, 2013, v. 331, n. 1, p. 1-10-
dc.identifier.issn0304-3835-
dc.identifier.urihttp://hdl.handle.net/10722/325258-
dc.description.abstractMicroRNAs (miRNAs) are members of non-coding RNAs. They are involved in diverse biological functions. MiRNAs are precisely regulated in a tissue- and developmental-specific manner, but dysregulated in many human diseases, in particular cancers. Transcriptional regulation, post-transcriptional regulation, as well as genetic alterations, are the three major mechanisms controlling the spatial and temporal expression of miRNAs. Emerging evidence now indicates that transcriptional and epigenetic regulations play major roles in miRNA expression. This review summarizes the current knowledge and discusses the future challenges. © 2012 Elsevier Ireland Ltd.-
dc.languageeng-
dc.relation.ispartofCancer Letters-
dc.subjectCancer-
dc.subjectEpigenetic regulation-
dc.subjectMiRNA-
dc.subjectTranscription machinery-
dc.subjectTranscriptional regulation-
dc.titleTranscriptional and epigenetic regulation of human microRNAs-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.canlet.2012.12.006-
dc.identifier.pmid23246373-
dc.identifier.scopuseid_2-s2.0-84873523265-
dc.identifier.volume331-
dc.identifier.issue1-
dc.identifier.spage1-
dc.identifier.epage10-
dc.identifier.eissn1872-7980-
dc.identifier.isiWOS:000315610100001-

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