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Article: Mindfulness-based therapy for drug-resistant epilepsy

TitleMindfulness-based therapy for drug-resistant epilepsy
Authors
Issue Date2015
Citation
Neurology, 2015, v. 85, n. 13, p. 1100-1107 How to Cite?
AbstractObjective: To investigate the effectiveness of mindfulness-based therapy (MT) and social support (SS) in patients with drug-resistant epilepsy. Methods: We performed an assessor-blinded randomized control trial. Sixty patients with drug-resistant epilepsy were randomly allocated to MT or SS (30 per group). Each group received 4 biweekly intervention sessions. The primary outcome was the change in the total score of the Patient-Weighted Quality of Life in Epilepsy Inventory (QOLIE-31-P). Secondary outcomes included seizure frequency, mood symptoms, and neurocognitive functions. The assessors were blinded to the patient's intervention grouping. Results were analyzed using general linear model with repeated measure. Results: Following intervention, both the MT (n 30) and SS (n 30) groups had an improved total QOLIE-31-P, with an improvement of +6.23 for MT (95% confidence interval [CI] +4.22 to +10.40) and +3.30 for SS (95% CI +1.03 to +5.58). Significantly more patients in the MT group had a clinically important improvement in QOLIE-31-P (+11.8 or above) compared to those who received SS (11 patients vs 4 patients). Significantly greater reduction in depressive and anxiety symptoms, seizure frequency, and improvement in delayed memory was observed in the MT group compared with the SS group. Conclusions: We found benefits of short-term psychotherapy on patients with drug-resistant epilepsy. Mindfulness therapy was associated with greater benefits than SS alone in quality of life, mood, seizure frequency, and verbal memory. Classification of evidence: This study provides Class II evidence that mindfulness-based therapy significantly improves quality of life in patients with drug-resistant epilepsy.
Persistent Identifierhttp://hdl.handle.net/10722/325304
ISSN
2023 Impact Factor: 7.7
2023 SCImago Journal Rankings: 2.404
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTang, Venus-
dc.contributor.authorPoon, Wai S.-
dc.contributor.authorKwan, Patrick-
dc.date.accessioned2023-02-27T07:31:23Z-
dc.date.available2023-02-27T07:31:23Z-
dc.date.issued2015-
dc.identifier.citationNeurology, 2015, v. 85, n. 13, p. 1100-1107-
dc.identifier.issn0028-3878-
dc.identifier.urihttp://hdl.handle.net/10722/325304-
dc.description.abstractObjective: To investigate the effectiveness of mindfulness-based therapy (MT) and social support (SS) in patients with drug-resistant epilepsy. Methods: We performed an assessor-blinded randomized control trial. Sixty patients with drug-resistant epilepsy were randomly allocated to MT or SS (30 per group). Each group received 4 biweekly intervention sessions. The primary outcome was the change in the total score of the Patient-Weighted Quality of Life in Epilepsy Inventory (QOLIE-31-P). Secondary outcomes included seizure frequency, mood symptoms, and neurocognitive functions. The assessors were blinded to the patient's intervention grouping. Results were analyzed using general linear model with repeated measure. Results: Following intervention, both the MT (n 30) and SS (n 30) groups had an improved total QOLIE-31-P, with an improvement of +6.23 for MT (95% confidence interval [CI] +4.22 to +10.40) and +3.30 for SS (95% CI +1.03 to +5.58). Significantly more patients in the MT group had a clinically important improvement in QOLIE-31-P (+11.8 or above) compared to those who received SS (11 patients vs 4 patients). Significantly greater reduction in depressive and anxiety symptoms, seizure frequency, and improvement in delayed memory was observed in the MT group compared with the SS group. Conclusions: We found benefits of short-term psychotherapy on patients with drug-resistant epilepsy. Mindfulness therapy was associated with greater benefits than SS alone in quality of life, mood, seizure frequency, and verbal memory. Classification of evidence: This study provides Class II evidence that mindfulness-based therapy significantly improves quality of life in patients with drug-resistant epilepsy.-
dc.languageeng-
dc.relation.ispartofNeurology-
dc.titleMindfulness-based therapy for drug-resistant epilepsy-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1212/WNL.0000000000001967-
dc.identifier.pmid26333801-
dc.identifier.scopuseid_2-s2.0-84948985825-
dc.identifier.volume85-
dc.identifier.issue13-
dc.identifier.spage1100-
dc.identifier.epage1107-
dc.identifier.eissn1526-632X-
dc.identifier.isiWOS:000365644800004-

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