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Conference Paper: Magnesium sulphate for aneurysmal subarachnoid hemorrhage: Why, how, and current controversy

TitleMagnesium sulphate for aneurysmal subarachnoid hemorrhage: Why, how, and current controversy
Authors
Wong, George Kwok ChuPoon, Wai Sang
KeywordsClinical outcome
Delayed cerebral ischemia
Magnesium
Stroke
Subarachnoid hemorrhage
Issue Date2013
PublisherSpringer
Citation
11th International Conference on Cerebral Vasospasm, Cincinnati, Ohio, USA, July 2011. In Zuccarello, M, Clark, JF, Pyne-Geithman, G, et al. (Eds.), Cerebral Vasospasm: Neurovascular Events After Subarachnoid Hemorrhage, p. 45-48. Vienna: Springer, 2013 How to Cite?
DOI: http://dx.doi.org/10.1007/978-3-7091-1192-5_10
AbstractThe neuroprotective effect of magnesium sulphate infusion has been confirmed in experimental models. Pilot clinical trials using magnesium sulphate in patients with acute aneurysmal subarachnoid hemorrhage (SAH) have reported a trend toward a reduction in clinical deterioration due to delayed cerebral ischemia (DCI) and an improvement in clinical outcomes. However, our recent multicenter trials and systemic review failed to confirm benefit in neurological outcome. In post hoc analysis, data also did not support that a higher dose of magnesium sulphate infusion might improve clinical outcome. We here review the current literature, highlight these discrepancies, and explore alternatives. © 2013 Springer-Verlag Wien.
Persistent Identifierhttp://hdl.handle.net/10722/325401
ISBN
9783709111918
ISSN
0065-1419
2019 SCImago Journal Rankings: 0.320
Series/Report no.Acta Neurochirurgica. Supplement ; 115

 

DC FieldValueLanguage
dc.contributor.authorWong, George Kwok Chu-
dc.contributor.authorPoon, Wai Sang-
dc.date.accessioned2023-02-27T07:32:34Z-
dc.date.available2023-02-27T07:32:34Z-
dc.date.issued2013-
dc.identifier.citation11th International Conference on Cerebral Vasospasm, Cincinnati, Ohio, USA, July 2011. In Zuccarello, M, Clark, JF, Pyne-Geithman, G, et al. (Eds.), Cerebral Vasospasm: Neurovascular Events After Subarachnoid Hemorrhage, p. 45-48. Vienna: Springer, 2013-
dc.identifier.isbn9783709111918-
dc.identifier.issn0065-1419-
dc.identifier.urihttp://hdl.handle.net/10722/325401-
dc.description.abstractThe neuroprotective effect of magnesium sulphate infusion has been confirmed in experimental models. Pilot clinical trials using magnesium sulphate in patients with acute aneurysmal subarachnoid hemorrhage (SAH) have reported a trend toward a reduction in clinical deterioration due to delayed cerebral ischemia (DCI) and an improvement in clinical outcomes. However, our recent multicenter trials and systemic review failed to confirm benefit in neurological outcome. In post hoc analysis, data also did not support that a higher dose of magnesium sulphate infusion might improve clinical outcome. We here review the current literature, highlight these discrepancies, and explore alternatives. © 2013 Springer-Verlag Wien.-
dc.languageeng-
dc.publisherSpringer-
dc.relation.ispartofCerebral Vasospasm: Neurovascular Events After Subarachnoid Hemorrhage-
dc.relation.ispartofseriesActa Neurochirurgica. Supplement ; 115-
dc.subjectClinical outcome-
dc.subjectDelayed cerebral ischemia-
dc.subjectMagnesium-
dc.subjectStroke-
dc.subjectSubarachnoid hemorrhage-
dc.titleMagnesium sulphate for aneurysmal subarachnoid hemorrhage: Why, how, and current controversy-
dc.typeConference_Paper-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/978-3-7091-1192-5_10-
dc.identifier.pmid22890642-
dc.identifier.scopuseid_2-s2.0-85052608807-
dc.identifier.volume115-
dc.identifier.spage45-
dc.identifier.epage48-
dc.identifier.eissn0001-6268-
dc.publisher.placeVienna-

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