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Article: The effect of hypermagnesemic treatment on cerebrospinal fluid magnesium level in patients with aneurysmal subarachnoid hemorrhage

TitleThe effect of hypermagnesemic treatment on cerebrospinal fluid magnesium level in patients with aneurysmal subarachnoid hemorrhage
Authors
KeywordsCerebrospinal fluid
Intracranial aneurysm
Magnesium
Subarachnoid hemorrhage
Issue Date2009
Citation
Magnesium Research, 2009, v. 22, n. 2, p. 60-65 How to Cite?
AbstractPreliminary evidence has suggested that magnesium sulfate infusion reduces delayed ischemic neurological deficit and improves clinical outcome after aneurysmal subarachnoid hemorrhage. However, little is known about its site of action in vivo. We studied 22 aneurysmal subarachnoid hemorrhage patients with or without magnesium sulfate infusion for 10-14 days. Thirteen patients had external ventricular drains inserted for hydrocephalus and daily cerebrospinal fluid magnesium levels were measured. For patients given magnesium sulfate infusion, the aim was to raise the plasma magnesium level to double the baseline level. We found that the magnesium sulfate infusion bought an 11% to 21% increase in cerebrospinal fluid magnesium. The elevation of cerebrospinal fluid magnesium was sustained for at least nine days. Whether this mild elevation in cerebrospinal fluid magnesium level was adequate for neuroprotection awaits the results of ongoing clinical trials.
Persistent Identifierhttp://hdl.handle.net/10722/325611
ISSN
2023 Impact Factor: 1.5
2023 SCImago Journal Rankings: 0.290
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWong, George K.C.-
dc.contributor.authorLam, Christopher W.K.-
dc.contributor.authorChan, Mathew T.V.-
dc.contributor.authorGin, Tony-
dc.contributor.authorPoon, Wai S.-
dc.date.accessioned2023-02-27T07:34:45Z-
dc.date.available2023-02-27T07:34:45Z-
dc.date.issued2009-
dc.identifier.citationMagnesium Research, 2009, v. 22, n. 2, p. 60-65-
dc.identifier.issn0953-1424-
dc.identifier.urihttp://hdl.handle.net/10722/325611-
dc.description.abstractPreliminary evidence has suggested that magnesium sulfate infusion reduces delayed ischemic neurological deficit and improves clinical outcome after aneurysmal subarachnoid hemorrhage. However, little is known about its site of action in vivo. We studied 22 aneurysmal subarachnoid hemorrhage patients with or without magnesium sulfate infusion for 10-14 days. Thirteen patients had external ventricular drains inserted for hydrocephalus and daily cerebrospinal fluid magnesium levels were measured. For patients given magnesium sulfate infusion, the aim was to raise the plasma magnesium level to double the baseline level. We found that the magnesium sulfate infusion bought an 11% to 21% increase in cerebrospinal fluid magnesium. The elevation of cerebrospinal fluid magnesium was sustained for at least nine days. Whether this mild elevation in cerebrospinal fluid magnesium level was adequate for neuroprotection awaits the results of ongoing clinical trials.-
dc.languageeng-
dc.relation.ispartofMagnesium Research-
dc.subjectCerebrospinal fluid-
dc.subjectIntracranial aneurysm-
dc.subjectMagnesium-
dc.subjectSubarachnoid hemorrhage-
dc.titleThe effect of hypermagnesemic treatment on cerebrospinal fluid magnesium level in patients with aneurysmal subarachnoid hemorrhage-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1684/mrh.2009.0167-
dc.identifier.pmid19658274-
dc.identifier.scopuseid_2-s2.0-67650818943-
dc.identifier.volume22-
dc.identifier.issue2-
dc.identifier.spage60-
dc.identifier.epage65-
dc.identifier.eissn1952-4021-
dc.identifier.isiWOS:000267673200002-

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