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Article: Cognitive domain deficits in patients with aneurysmal subarachnoid haemorrhage at 1 year
Title | Cognitive domain deficits in patients with aneurysmal subarachnoid haemorrhage at 1 year |
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Authors | |
Issue Date | 2013 |
Citation | Journal of Neurology, Neurosurgery and Psychiatry, 2013, v. 84, n. 9, p. 1054-1058 How to Cite? |
Abstract | Background: Cognitive domain deficits can occur after aneurysmal subarachnoid haemorrhage (aSAH) though few studies systemically evaluate its impact on 1-year outcomes. Objective: We aimed to evaluate the pattern and functional outcome impact of cognitive domain deficits in aSAH patients at 1 year. Methods: We carried out a prospective observational study in Hong Kong, during which, 168 aSAH patients (aged 21-75 years and had been admitted within 96 h of ictus) were recruited over a 26-month period. The cognitive function was assessed by a domain-specific neuropsychological assessment battery at 1 year after ictus. The current study is registered at ClinicalTrials.gov of the US National Institutes of Health (NCT01038193). Results: Prevalence of individual domain deficits varied between 7% to 15%, and 13% had two or more domain deficits. After adjusting for abbreviated National Institute of Health Stroke Scale and Geriatric Depressive Scale scores, unfavourable outcome (Modified Rankin Scale 3-5) and dependent instrumental activity of daily living (Lawton Instrumental Activity of Daily Living<15) were significantly associated with two or more domain deficits and number of cognitive domain deficits at 1 year. Two or more domain deficits was independently associated with age (OR, 1.1; 95% CI 1.1 to 1.2; p<0.001) and delayed cerebral infarction (OR, 6.1; 95% CI 1.1 to 33.5; p=0.036), after adjustment for years of school education. Interpretation: In patients with aSAH, cognitive domain deficits worsened functional outcomes at 1 year. Delayed cerebral infarction was an independent risk factor for two or more domain deficits at 1 year. |
Persistent Identifier | http://hdl.handle.net/10722/325629 |
ISSN | 2023 Impact Factor: 8.7 2023 SCImago Journal Rankings: 2.959 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Wong, George Kwok Chu | - |
dc.contributor.author | Lam, Sandy Wai | - |
dc.contributor.author | Ngai, Karine | - |
dc.contributor.author | Wong, Adrian | - |
dc.contributor.author | Siu, Deyond | - |
dc.contributor.author | Poon, Wai Sang | - |
dc.contributor.author | Mok, Vincent | - |
dc.date.accessioned | 2023-02-27T07:34:53Z | - |
dc.date.available | 2023-02-27T07:34:53Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Journal of Neurology, Neurosurgery and Psychiatry, 2013, v. 84, n. 9, p. 1054-1058 | - |
dc.identifier.issn | 0022-3050 | - |
dc.identifier.uri | http://hdl.handle.net/10722/325629 | - |
dc.description.abstract | Background: Cognitive domain deficits can occur after aneurysmal subarachnoid haemorrhage (aSAH) though few studies systemically evaluate its impact on 1-year outcomes. Objective: We aimed to evaluate the pattern and functional outcome impact of cognitive domain deficits in aSAH patients at 1 year. Methods: We carried out a prospective observational study in Hong Kong, during which, 168 aSAH patients (aged 21-75 years and had been admitted within 96 h of ictus) were recruited over a 26-month period. The cognitive function was assessed by a domain-specific neuropsychological assessment battery at 1 year after ictus. The current study is registered at ClinicalTrials.gov of the US National Institutes of Health (NCT01038193). Results: Prevalence of individual domain deficits varied between 7% to 15%, and 13% had two or more domain deficits. After adjusting for abbreviated National Institute of Health Stroke Scale and Geriatric Depressive Scale scores, unfavourable outcome (Modified Rankin Scale 3-5) and dependent instrumental activity of daily living (Lawton Instrumental Activity of Daily Living<15) were significantly associated with two or more domain deficits and number of cognitive domain deficits at 1 year. Two or more domain deficits was independently associated with age (OR, 1.1; 95% CI 1.1 to 1.2; p<0.001) and delayed cerebral infarction (OR, 6.1; 95% CI 1.1 to 33.5; p=0.036), after adjustment for years of school education. Interpretation: In patients with aSAH, cognitive domain deficits worsened functional outcomes at 1 year. Delayed cerebral infarction was an independent risk factor for two or more domain deficits at 1 year. | - |
dc.language | eng | - |
dc.relation.ispartof | Journal of Neurology, Neurosurgery and Psychiatry | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.title | Cognitive domain deficits in patients with aneurysmal subarachnoid haemorrhage at 1 year | - |
dc.type | Article | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1136/jnnp-2012-304517 | - |
dc.identifier.pmid | 23606736 | - |
dc.identifier.pmcid | PMC3756437 | - |
dc.identifier.scopus | eid_2-s2.0-84881558373 | - |
dc.identifier.volume | 84 | - |
dc.identifier.issue | 9 | - |
dc.identifier.spage | 1054 | - |
dc.identifier.epage | 1058 | - |
dc.identifier.eissn | 1468-330X | - |
dc.identifier.isi | WOS:000323164000022 | - |