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- Publisher Website: 10.1007/BF02013639
- Scopus: eid_2-s2.0-0030112019
- PMID: 10887489
- WOS: WOS:000208468100003
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Article: Cyclins and breast cancer.
Title | Cyclins and breast cancer. |
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Authors | |
Issue Date | 1996 |
Citation | Journal of mammary gland biology and neoplasia, 1996, v. 1, n. 2, p. 153-162 How to Cite? |
Abstract | Recent advances in the understanding of cell cycle control by cyclins and cyclin-dependent kinases provide a basis for delineating the molecular mechanisms of proliferation control by steroids and the development and progression of hormone-dependent cancers. Cyclin D1 is necessary, rate-limiting and sufficient for G1 progression in breast cancer cells and regulation of cyclin D1 expression or function is an early response to steroid and steroid antagonist regulation of proliferation. The cyclin D1 gene is amplified in approximately 15%, and its product overexpressed in 40-50%, of primary breast carcinomas. The strong evidence that cyclin D1 plays a major role in cell cycle control in breast epithelial cells suggests that its deregulated expression may have effects on disease progression and phenotype including sensitivity to endocrine therapies. |
Persistent Identifier | http://hdl.handle.net/10722/326441 |
ISSN | 2023 Impact Factor: 3.0 2023 SCImago Journal Rankings: 0.964 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Musgrove, E. A. | - |
dc.contributor.author | Hui, R. | - |
dc.contributor.author | Sweeney, K. J. | - |
dc.contributor.author | Watts, C. K. | - |
dc.contributor.author | Sutherland, R. L. | - |
dc.date.accessioned | 2023-03-10T02:19:18Z | - |
dc.date.available | 2023-03-10T02:19:18Z | - |
dc.date.issued | 1996 | - |
dc.identifier.citation | Journal of mammary gland biology and neoplasia, 1996, v. 1, n. 2, p. 153-162 | - |
dc.identifier.issn | 1083-3021 | - |
dc.identifier.uri | http://hdl.handle.net/10722/326441 | - |
dc.description.abstract | Recent advances in the understanding of cell cycle control by cyclins and cyclin-dependent kinases provide a basis for delineating the molecular mechanisms of proliferation control by steroids and the development and progression of hormone-dependent cancers. Cyclin D1 is necessary, rate-limiting and sufficient for G1 progression in breast cancer cells and regulation of cyclin D1 expression or function is an early response to steroid and steroid antagonist regulation of proliferation. The cyclin D1 gene is amplified in approximately 15%, and its product overexpressed in 40-50%, of primary breast carcinomas. The strong evidence that cyclin D1 plays a major role in cell cycle control in breast epithelial cells suggests that its deregulated expression may have effects on disease progression and phenotype including sensitivity to endocrine therapies. | - |
dc.language | eng | - |
dc.relation.ispartof | Journal of mammary gland biology and neoplasia | - |
dc.title | Cyclins and breast cancer. | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1007/BF02013639 | - |
dc.identifier.pmid | 10887489 | - |
dc.identifier.scopus | eid_2-s2.0-0030112019 | - |
dc.identifier.volume | 1 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 153 | - |
dc.identifier.epage | 162 | - |
dc.identifier.isi | WOS:000208468100003 | - |