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- Publisher Website: 10.1155/2020/8815349
- Scopus: eid_2-s2.0-85099295280
- PMID: 33488934
- WOS: WOS:000609494100009
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Article: Pharmacological Modulation of Cardiac Remodeling after Myocardial Infarction
Title | Pharmacological Modulation of Cardiac Remodeling after Myocardial Infarction |
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Authors | |
Issue Date | 2020 |
Citation | Oxidative Medicine and Cellular Longevity, 2020, v. 2020, article no. 8815349 How to Cite? |
Abstract | Cardiac remodeling describes a series of structural and functional changes in the heart after myocardial infarction (MI). Adverse post-MI cardiac remodeling directly jeopardizes the recovery of cardiac functions and the survival rate in MI patients. Several classes of drugs are proven to be useful to reduce the mortality of MI patients. However, it is an ongoing challenge to prevent the adverse effects of cardiac remodeling. The present review aims to identify the pharmacological therapies from the existing clinical drugs for the treatment of adverse post-MI cardiac remodeling. Post-MI cardiac remodeling is a complex process involving ischemia/reperfusion, inflammation, cell death, and deposition of extracellular matrix (ECM). Thus, the present review included two parts: (1) to examine the basic pathophysiology in the cardiovascular system and the molecular basis of cardiac remodeling and (2) to identify the pathological aspects of cardiac remodeling and the potential of the existing pharmacotherapies. Ultimately, the present review highlights drug repositioning as a strategy to discover effective therapies from the existing drugs against post-MI cardiac remodeling. |
Persistent Identifier | http://hdl.handle.net/10722/327314 |
ISSN | 2021 Impact Factor: 7.310 2023 SCImago Journal Rankings: 1.477 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Zhao, Wei | - |
dc.contributor.author | Zhao, Jia | - |
dc.contributor.author | Rong, Jianhui | - |
dc.date.accessioned | 2023-03-31T05:30:27Z | - |
dc.date.available | 2023-03-31T05:30:27Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Oxidative Medicine and Cellular Longevity, 2020, v. 2020, article no. 8815349 | - |
dc.identifier.issn | 1942-0900 | - |
dc.identifier.uri | http://hdl.handle.net/10722/327314 | - |
dc.description.abstract | Cardiac remodeling describes a series of structural and functional changes in the heart after myocardial infarction (MI). Adverse post-MI cardiac remodeling directly jeopardizes the recovery of cardiac functions and the survival rate in MI patients. Several classes of drugs are proven to be useful to reduce the mortality of MI patients. However, it is an ongoing challenge to prevent the adverse effects of cardiac remodeling. The present review aims to identify the pharmacological therapies from the existing clinical drugs for the treatment of adverse post-MI cardiac remodeling. Post-MI cardiac remodeling is a complex process involving ischemia/reperfusion, inflammation, cell death, and deposition of extracellular matrix (ECM). Thus, the present review included two parts: (1) to examine the basic pathophysiology in the cardiovascular system and the molecular basis of cardiac remodeling and (2) to identify the pathological aspects of cardiac remodeling and the potential of the existing pharmacotherapies. Ultimately, the present review highlights drug repositioning as a strategy to discover effective therapies from the existing drugs against post-MI cardiac remodeling. | - |
dc.language | eng | - |
dc.relation.ispartof | Oxidative Medicine and Cellular Longevity | - |
dc.title | Pharmacological Modulation of Cardiac Remodeling after Myocardial Infarction | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1155/2020/8815349 | - |
dc.identifier.pmid | 33488934 | - |
dc.identifier.scopus | eid_2-s2.0-85099295280 | - |
dc.identifier.volume | 2020 | - |
dc.identifier.spage | article no. 8815349 | - |
dc.identifier.epage | article no. 8815349 | - |
dc.identifier.eissn | 1942-0994 | - |
dc.identifier.isi | WOS:000609494100009 | - |