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- Publisher Website: 10.1002/nbm.4640
- Scopus: eid_2-s2.0-85118613878
- PMID: 34750891
- WOS: WOS:000715882200001
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Article: Sensitivity schemes for dynamic glucose-enhanced magnetic resonance imaging to detect glucose uptake and clearance in mouse brain at 3 T
Title | Sensitivity schemes for dynamic glucose-enhanced magnetic resonance imaging to detect glucose uptake and clearance in mouse brain at 3 T |
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Authors | |
Keywords | Carr–Purcell–Meiboom–Gill cerebrospinal fluid dynamic glucose-enhanced multilinear singular value decomposition on-resonance spin-lock on-resonance variable delay multipulse parenchyma |
Issue Date | 2022 |
Citation | NMR in Biomedicine, 2022, v. 35, n. 3, article no. e4640 How to Cite? |
Abstract | We investigated three dynamic glucose-enhanced (DGE) MRI methods for sensitively monitoring glucose uptake and clearance in both brain parenchyma and cerebrospinal fluid (CSF) at clinical field strength (3 T). By comparing three sequences, namely, Carr–Purcell–Meiboom–Gill (CPMG), on-resonance variable delay multipulse (onVDMP), and on-resonance spin-lock (onSL), a high-sensitivity DGE MRI scheme with truncated multilinear singular value decomposition (MLSVD) denoising was proposed. The CPMG method showed the highest sensitivity in detecting the parenchymal DGE signal among the three methods, while both onVDMP and onSL were more robust for CSF DGE imaging. Here, onVDMP was applied for CSF imaging, as it displayed the best stability of the DGE results in this study. The truncated MLSVD denoising method was incorporated to further improve the sensitivity. The proposed DGE MRI scheme was examined in mouse brain with 50%/25%/12.5% w/w D-glucose injections. The results showed that this combination could detect DGE signal changes from the brain parenchyma and CSF with as low as a 12.5% w/w D-glucose injection. The proposed DGE MRI schemes could sensitively detect the glucose signal change from brain parenchyma and CSF after D-glucose injection at a clinically relevant concentration, demonstrating high potential for clinical translation. |
Persistent Identifier | http://hdl.handle.net/10722/327913 |
ISSN | 2023 Impact Factor: 2.7 2023 SCImago Journal Rankings: 0.949 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Huang, Jianpan | - |
dc.contributor.author | Lai, Joseph H.C. | - |
dc.contributor.author | Han, Xiongqi | - |
dc.contributor.author | Chen, Zilin | - |
dc.contributor.author | Xiao, Peng | - |
dc.contributor.author | Liu, Yang | - |
dc.contributor.author | Chen, Lin | - |
dc.contributor.author | Xu, Jiadi | - |
dc.contributor.author | Chan, Kannie W.Y. | - |
dc.date.accessioned | 2023-06-05T06:52:37Z | - |
dc.date.available | 2023-06-05T06:52:37Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | NMR in Biomedicine, 2022, v. 35, n. 3, article no. e4640 | - |
dc.identifier.issn | 0952-3480 | - |
dc.identifier.uri | http://hdl.handle.net/10722/327913 | - |
dc.description.abstract | We investigated three dynamic glucose-enhanced (DGE) MRI methods for sensitively monitoring glucose uptake and clearance in both brain parenchyma and cerebrospinal fluid (CSF) at clinical field strength (3 T). By comparing three sequences, namely, Carr–Purcell–Meiboom–Gill (CPMG), on-resonance variable delay multipulse (onVDMP), and on-resonance spin-lock (onSL), a high-sensitivity DGE MRI scheme with truncated multilinear singular value decomposition (MLSVD) denoising was proposed. The CPMG method showed the highest sensitivity in detecting the parenchymal DGE signal among the three methods, while both onVDMP and onSL were more robust for CSF DGE imaging. Here, onVDMP was applied for CSF imaging, as it displayed the best stability of the DGE results in this study. The truncated MLSVD denoising method was incorporated to further improve the sensitivity. The proposed DGE MRI scheme was examined in mouse brain with 50%/25%/12.5% w/w D-glucose injections. The results showed that this combination could detect DGE signal changes from the brain parenchyma and CSF with as low as a 12.5% w/w D-glucose injection. The proposed DGE MRI schemes could sensitively detect the glucose signal change from brain parenchyma and CSF after D-glucose injection at a clinically relevant concentration, demonstrating high potential for clinical translation. | - |
dc.language | eng | - |
dc.relation.ispartof | NMR in Biomedicine | - |
dc.subject | Carr–Purcell–Meiboom–Gill | - |
dc.subject | cerebrospinal fluid | - |
dc.subject | dynamic glucose-enhanced | - |
dc.subject | multilinear singular value decomposition | - |
dc.subject | on-resonance spin-lock | - |
dc.subject | on-resonance variable delay multipulse | - |
dc.subject | parenchyma | - |
dc.title | Sensitivity schemes for dynamic glucose-enhanced magnetic resonance imaging to detect glucose uptake and clearance in mouse brain at 3 T | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1002/nbm.4640 | - |
dc.identifier.pmid | 34750891 | - |
dc.identifier.scopus | eid_2-s2.0-85118613878 | - |
dc.identifier.volume | 35 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | article no. e4640 | - |
dc.identifier.epage | article no. e4640 | - |
dc.identifier.eissn | 1099-1492 | - |
dc.identifier.isi | WOS:000715882200001 | - |