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Article: D-Glucose uptake and clearance in the tauopathy Alzheimer’s disease mouse brain detected by on-resonance variable delay multiple pulse MRI

TitleD-Glucose uptake and clearance in the tauopathy Alzheimer’s disease mouse brain detected by on-resonance variable delay multiple pulse MRI
Authors
KeywordsAlzheimer’s diseases
chemical exchange saturation transfer
dynamic glucose enhanced
Glucose uptake
on-resonance variable delay multiple pulse
tau pathology
Issue Date2021
Citation
Journal of Cerebral Blood Flow and Metabolism, 2021, v. 41, n. 5, p. 1013-1025 How to Cite?
AbstractIn this study, we applied on-resonance variable delay multiple pulse (onVDMP) MRI to study D-glucose uptake in a mouse model of Alzheimer’s disease (AD) tauopathy and demonstrated its feasibility in discriminating AD mice from wild-type mice. The D-glucose uptake in the cortex of AD mice (1.70 ± 1.33%) was significantly reduced compared to that of wild-type mice (5.42 ± 0.70%, p = 0.0051). Also, a slower D-glucose uptake rate was found in the cerebrospinal fluid (CSF) of AD mice (0.08 ± 0.01 min−1) compared to their wild-type counterpart (0.56 ± 0.1 min−1, p < 0.001), which suggests the presence of an impaired glucose transporter on both blood–brain and blood–CSF barriers of these AD mice. Clearance of D-glucose was observed in the CSF of wild-type mice but not AD mice, which suggests dysfunction of the glymphatic system in the AD mice. The results in this study indicate that onVDMP MRI could be a cost-effective and widely available method for simultaneously evaluating glucose transporter and glymphatic function of AD. This study also suggests that tau protein affects the D-glucose uptake and glymphatic impairment in AD at a time point preceding neurofibrillary tangle pathology.
Persistent Identifierhttp://hdl.handle.net/10722/327987
ISSN
2023 Impact Factor: 4.9
2023 SCImago Journal Rankings: 1.937
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChen, Lin-
dc.contributor.authorWei, Zhiliang-
dc.contributor.authorChan, Kannie W.Y.-
dc.contributor.authorLi, Yuguo-
dc.contributor.authorSuchal, Kapil-
dc.contributor.authorBi, Sheng-
dc.contributor.authorHuang, Jianpan-
dc.contributor.authorXu, Xiang-
dc.contributor.authorWong, Philip C.-
dc.contributor.authorLu, Hanzhang-
dc.contributor.authorvan Zijl, Peter C.M.-
dc.contributor.authorLi, Tong-
dc.contributor.authorXu, Jiadi-
dc.date.accessioned2023-06-05T06:53:08Z-
dc.date.available2023-06-05T06:53:08Z-
dc.date.issued2021-
dc.identifier.citationJournal of Cerebral Blood Flow and Metabolism, 2021, v. 41, n. 5, p. 1013-1025-
dc.identifier.issn0271-678X-
dc.identifier.urihttp://hdl.handle.net/10722/327987-
dc.description.abstractIn this study, we applied on-resonance variable delay multiple pulse (onVDMP) MRI to study D-glucose uptake in a mouse model of Alzheimer’s disease (AD) tauopathy and demonstrated its feasibility in discriminating AD mice from wild-type mice. The D-glucose uptake in the cortex of AD mice (1.70 ± 1.33%) was significantly reduced compared to that of wild-type mice (5.42 ± 0.70%, p = 0.0051). Also, a slower D-glucose uptake rate was found in the cerebrospinal fluid (CSF) of AD mice (0.08 ± 0.01 min−1) compared to their wild-type counterpart (0.56 ± 0.1 min−1, p < 0.001), which suggests the presence of an impaired glucose transporter on both blood–brain and blood–CSF barriers of these AD mice. Clearance of D-glucose was observed in the CSF of wild-type mice but not AD mice, which suggests dysfunction of the glymphatic system in the AD mice. The results in this study indicate that onVDMP MRI could be a cost-effective and widely available method for simultaneously evaluating glucose transporter and glymphatic function of AD. This study also suggests that tau protein affects the D-glucose uptake and glymphatic impairment in AD at a time point preceding neurofibrillary tangle pathology.-
dc.languageeng-
dc.relation.ispartofJournal of Cerebral Blood Flow and Metabolism-
dc.subjectAlzheimer’s diseases-
dc.subjectchemical exchange saturation transfer-
dc.subjectdynamic glucose enhanced-
dc.subjectGlucose uptake-
dc.subjecton-resonance variable delay multiple pulse-
dc.subjecttau pathology-
dc.titleD-Glucose uptake and clearance in the tauopathy Alzheimer’s disease mouse brain detected by on-resonance variable delay multiple pulse MRI-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1177/0271678X20941264-
dc.identifier.pmid32669023-
dc.identifier.scopuseid_2-s2.0-85088007895-
dc.identifier.volume41-
dc.identifier.issue5-
dc.identifier.spage1013-
dc.identifier.epage1025-
dc.identifier.eissn1559-7016-
dc.identifier.isiWOS:000549920000001-

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