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Article: Whole-brain amide CEST imaging at 3T with a steady-state radial MRI acquisition

TitleWhole-brain amide CEST imaging at 3T with a steady-state radial MRI acquisition
Authors
Keywordschemical exhange saturation transfer (CEST)
magnetization transfer contrast (MTC)
MultiVane
periodically rotated overlapping parallel lines with enhanced reconstruction (PROPELLER)
steady-state pulsed CEST/MTC
steady-state radial
Issue Date2021
Citation
Magnetic Resonance in Medicine, 2021, v. 86, n. 2, p. 893-906 How to Cite?
AbstractPurpose: To develop a steady-state saturation with radial readout chemical exchange saturation transfer (starCEST) for acquiring CEST images at 3 Tesla (T). The polynomial Lorentzian line-shape fitting approach was further developed for extracting amideCEST intensities at this field. Method: StarCEST MRI using periodically rotated overlapping parallel lines with enhanced reconstruction-based spatial sampling was implemented to acquire Z-spectra that are robust to brain motion. Multi-linear singular value decomposition postprocessing was applied to enhance the CEST SNR. The egg white phantom studies were performed at 3T to reveal the contributions to the 3.5 ppm CEST signal. Based on the phantom validation, the amideCEST peak was quantified using the polynomial Lorentzian line-shape fitting, which exploits the inverse relationship between Z-spectral intensity and the longitudinal relaxation rate in the rotating frame. The 3D turbo spin echo CEST was also performed to compare with the starCEST method. Results: The amideCEST peak showed a negligible peak B1 dependence between 1.2 µT and 2.4 µT. The amideCEST images acquired with starCEST showed much improved image quality, SNR, and motion robustness compared to the conventional 3D turbo spin echo CEST method with the same scan time. The amideCEST contrast extracted by the polynomial Lorentzian line-shape fitting method trended toward a stronger gray matter signal (1.32% ± 0.30%) than white matter (0.92% ± 0.08%; P =.02, n = 5). When calculating the magnetization transfer contrast and T1-corrected rotating frame relaxation rate maps, amideCEST again was not significantly different for white matter and gray matter. Conclusion: Rapid multi-slice amideCEST mapping can be achieved by the starCEST method (< 5 min) at 3T by combing with the polynomial Lorentzian line-shape fitting method.
Persistent Identifierhttp://hdl.handle.net/10722/327993
ISSN
2023 Impact Factor: 3.0
2023 SCImago Journal Rankings: 1.343
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSui, Ran-
dc.contributor.authorChen, Lin-
dc.contributor.authorLi, Yuguo-
dc.contributor.authorHuang, Jianpan-
dc.contributor.authorChan, Kannie W.Y.-
dc.contributor.authorXu, Xiang-
dc.contributor.authorvan Zijl, Peter C.M.-
dc.contributor.authorXu, Jiadi-
dc.date.accessioned2023-06-05T06:53:11Z-
dc.date.available2023-06-05T06:53:11Z-
dc.date.issued2021-
dc.identifier.citationMagnetic Resonance in Medicine, 2021, v. 86, n. 2, p. 893-906-
dc.identifier.issn0740-3194-
dc.identifier.urihttp://hdl.handle.net/10722/327993-
dc.description.abstractPurpose: To develop a steady-state saturation with radial readout chemical exchange saturation transfer (starCEST) for acquiring CEST images at 3 Tesla (T). The polynomial Lorentzian line-shape fitting approach was further developed for extracting amideCEST intensities at this field. Method: StarCEST MRI using periodically rotated overlapping parallel lines with enhanced reconstruction-based spatial sampling was implemented to acquire Z-spectra that are robust to brain motion. Multi-linear singular value decomposition postprocessing was applied to enhance the CEST SNR. The egg white phantom studies were performed at 3T to reveal the contributions to the 3.5 ppm CEST signal. Based on the phantom validation, the amideCEST peak was quantified using the polynomial Lorentzian line-shape fitting, which exploits the inverse relationship between Z-spectral intensity and the longitudinal relaxation rate in the rotating frame. The 3D turbo spin echo CEST was also performed to compare with the starCEST method. Results: The amideCEST peak showed a negligible peak B1 dependence between 1.2 µT and 2.4 µT. The amideCEST images acquired with starCEST showed much improved image quality, SNR, and motion robustness compared to the conventional 3D turbo spin echo CEST method with the same scan time. The amideCEST contrast extracted by the polynomial Lorentzian line-shape fitting method trended toward a stronger gray matter signal (1.32% ± 0.30%) than white matter (0.92% ± 0.08%; P =.02, n = 5). When calculating the magnetization transfer contrast and T1-corrected rotating frame relaxation rate maps, amideCEST again was not significantly different for white matter and gray matter. Conclusion: Rapid multi-slice amideCEST mapping can be achieved by the starCEST method (< 5 min) at 3T by combing with the polynomial Lorentzian line-shape fitting method.-
dc.languageeng-
dc.relation.ispartofMagnetic Resonance in Medicine-
dc.subjectchemical exhange saturation transfer (CEST)-
dc.subjectmagnetization transfer contrast (MTC)-
dc.subjectMultiVane-
dc.subjectperiodically rotated overlapping parallel lines with enhanced reconstruction (PROPELLER)-
dc.subjectsteady-state pulsed CEST/MTC-
dc.subjectsteady-state radial-
dc.titleWhole-brain amide CEST imaging at 3T with a steady-state radial MRI acquisition-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/mrm.28770-
dc.identifier.pmid33772859-
dc.identifier.scopuseid_2-s2.0-85103256303-
dc.identifier.volume86-
dc.identifier.issue2-
dc.identifier.spage893-
dc.identifier.epage906-
dc.identifier.eissn1522-2594-
dc.identifier.isiWOS:000633507800001-

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