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- Publisher Website: 10.1021/acsami.2c10493
- Scopus: eid_2-s2.0-85143494322
- PMID: 36448714
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Article: Monitor Tumor pHe and Response Longitudinally during Treatment Using CEST MRI-Detectable Alginate Microbeads
Title | Monitor Tumor pHe and Response Longitudinally during Treatment Using CEST MRI-Detectable Alginate Microbeads |
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Authors | |
Keywords | bicarbonate treatment CEST Iopamidol microfluidics pH monitor |
Issue Date | 2022 |
Citation | ACS Applied Materials and Interfaces, 2022, v. 14, n. 49, p. 54401-54410 How to Cite? |
Abstract | Imaging pHe of the tumor microenvironment has paramount importance for characterizing aggressive, invasive tumors, as well as therapeutic responses. Here, a robust approach to image pH changes in the tumor microenvironment longitudinally and during sodium bicarbonate treatment was reported. The pH-sensing microbeads were designed and prepared based on materials approved for clinical use, i.e., alginate microbead-containing computed tomography (CT) contrast-agent (iopamidol)-loaded liposomes (Iop-lipobeads). This Iop-lipobead prepared using a customized microfluidic device generated a CEST contrast of 10.6% at 4.2 ppm at pH 7.0, which was stable for 20 days in vitro. The CEST contrast decreased by 11.8% when the pH decreased from 7.0 to 6.5 in vitro. Optimized Iop-lipobeads next to tumors showed a significant increase of 19.7 ± 6.1% (p < 0.01) in CEST contrast at 4.2 ppm during the first 3 days of treatment and decreased to 15.2 ± 4.8% when treatment stopped. Notably, percentage changes in Iop-lipobeads were higher than that of amide CEST (11.7% and 9.1%) in tumors during and after treatment. These findings demonstrated that the Iop-lipobead could provide an independent and sensitive assessment of the pHe changes for a noninvasive and longitudinal monitoring of the treatment effects using multiple CEST contrast. |
Persistent Identifier | http://hdl.handle.net/10722/328005 |
ISSN | 2021 Impact Factor: 10.383 2020 SCImago Journal Rankings: 2.535 |
DC Field | Value | Language |
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dc.contributor.author | Xiao, Peng | - |
dc.contributor.author | Huang, Jianpan | - |
dc.contributor.author | Han, Xiongqi | - |
dc.contributor.author | Cheu, Jacinth W.S. | - |
dc.contributor.author | Liu, Yang | - |
dc.contributor.author | Law, Lok Hin | - |
dc.contributor.author | Lai, Joseph H.C. | - |
dc.contributor.author | Li, Jiyu | - |
dc.contributor.author | Park, Se Weon | - |
dc.contributor.author | Wong, Carmen C.L. | - |
dc.contributor.author | Lam, Raymond H.W. | - |
dc.contributor.author | Chan, Kannie W.Y. | - |
dc.date.accessioned | 2023-06-05T06:53:16Z | - |
dc.date.available | 2023-06-05T06:53:16Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | ACS Applied Materials and Interfaces, 2022, v. 14, n. 49, p. 54401-54410 | - |
dc.identifier.issn | 1944-8244 | - |
dc.identifier.uri | http://hdl.handle.net/10722/328005 | - |
dc.description.abstract | Imaging pHe of the tumor microenvironment has paramount importance for characterizing aggressive, invasive tumors, as well as therapeutic responses. Here, a robust approach to image pH changes in the tumor microenvironment longitudinally and during sodium bicarbonate treatment was reported. The pH-sensing microbeads were designed and prepared based on materials approved for clinical use, i.e., alginate microbead-containing computed tomography (CT) contrast-agent (iopamidol)-loaded liposomes (Iop-lipobeads). This Iop-lipobead prepared using a customized microfluidic device generated a CEST contrast of 10.6% at 4.2 ppm at pH 7.0, which was stable for 20 days in vitro. The CEST contrast decreased by 11.8% when the pH decreased from 7.0 to 6.5 in vitro. Optimized Iop-lipobeads next to tumors showed a significant increase of 19.7 ± 6.1% (p < 0.01) in CEST contrast at 4.2 ppm during the first 3 days of treatment and decreased to 15.2 ± 4.8% when treatment stopped. Notably, percentage changes in Iop-lipobeads were higher than that of amide CEST (11.7% and 9.1%) in tumors during and after treatment. These findings demonstrated that the Iop-lipobead could provide an independent and sensitive assessment of the pHe changes for a noninvasive and longitudinal monitoring of the treatment effects using multiple CEST contrast. | - |
dc.language | eng | - |
dc.relation.ispartof | ACS Applied Materials and Interfaces | - |
dc.subject | bicarbonate treatment | - |
dc.subject | CEST | - |
dc.subject | Iopamidol | - |
dc.subject | microfluidics | - |
dc.subject | pH monitor | - |
dc.title | Monitor Tumor pHe and Response Longitudinally during Treatment Using CEST MRI-Detectable Alginate Microbeads | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1021/acsami.2c10493 | - |
dc.identifier.pmid | 36448714 | - |
dc.identifier.scopus | eid_2-s2.0-85143494322 | - |
dc.identifier.volume | 14 | - |
dc.identifier.issue | 49 | - |
dc.identifier.spage | 54401 | - |
dc.identifier.epage | 54410 | - |
dc.identifier.eissn | 1944-8252 | - |