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- Publisher Website: 10.1038/s41443-021-00492-x
- Scopus: eid_2-s2.0-85118618151
- PMID: 34743192
- WOS: WOS:000715010700002
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Article: The relationship between testicular tumour characteristics and azoospermia: a systematic review
Title | The relationship between testicular tumour characteristics and azoospermia: a systematic review |
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Authors | |
Issue Date | 2022 |
Citation | International Journal of Impotence Research, 2022, v. 34, n. 6, p. 543-551 How to Cite? |
Abstract | Subfertility is a risk factor for testicular cancers (TT), and conversely, TT may induce subfertility due to local and regional toxic effects. We aimed to identify the association between TT characteristics and pre-orchidectomy azoospermia. A systematic review of the literature was performed according to the PRISMA checklist. Overall, eight non-randomised studies involving 469 men with TT (azoospermia, n = 57; no azoospermia n = 412) were included in the qualitative analysis. Bilateral TT (12.3% vs 2.9% in non-azoospermia), non-seminoma germ cell tumours (6.4% vs 1.9%), germ cell neoplasia in-situ (GCNIS) (11.1% vs 1.2%), stage 2–3 disease (22.2% vs 0%), Sertoli Cell only (SCO) on biopsy (60% vs 37.5%) and a history of undescended testis (UDT) (66.7% vs 50%) were more common in azoospermic men. FSH levels are higher (18.7–23.2 mIU/L vs <0.1–8 mIU/L in non-azoospermia), testosterone is lower, and testis size are smaller (lower range 1 mL vs 10 mL) in men with azoospermia. Leydig cell tumours and hyperplasia were only detected in men with azoospermia. In summary, bilateral TT, GCNIS, higher tumour stage, smaller testes, SCO and history of UDT may have direct effects on spermatogenesis. Small testis, raised FSH and low testosterone may reflect reduced testicular function in azoospermic men. Performing a pre-orchidectomy semen analysis is important to identify those with azoospermia or severe oligospermia in order to plan for cryopreservation or onco-TESE in young men who wish to conceive. |
Persistent Identifier | http://hdl.handle.net/10722/328816 |
ISSN | 2023 Impact Factor: 2.8 2023 SCImago Journal Rankings: 0.513 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Pang, Karl H. | - |
dc.contributor.author | Osman, Nadir I. | - |
dc.contributor.author | Muneer, Asif | - |
dc.contributor.author | Alnajjar, Hussain M. | - |
dc.date.accessioned | 2023-07-22T06:24:16Z | - |
dc.date.available | 2023-07-22T06:24:16Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | International Journal of Impotence Research, 2022, v. 34, n. 6, p. 543-551 | - |
dc.identifier.issn | 0955-9930 | - |
dc.identifier.uri | http://hdl.handle.net/10722/328816 | - |
dc.description.abstract | Subfertility is a risk factor for testicular cancers (TT), and conversely, TT may induce subfertility due to local and regional toxic effects. We aimed to identify the association between TT characteristics and pre-orchidectomy azoospermia. A systematic review of the literature was performed according to the PRISMA checklist. Overall, eight non-randomised studies involving 469 men with TT (azoospermia, n = 57; no azoospermia n = 412) were included in the qualitative analysis. Bilateral TT (12.3% vs 2.9% in non-azoospermia), non-seminoma germ cell tumours (6.4% vs 1.9%), germ cell neoplasia in-situ (GCNIS) (11.1% vs 1.2%), stage 2–3 disease (22.2% vs 0%), Sertoli Cell only (SCO) on biopsy (60% vs 37.5%) and a history of undescended testis (UDT) (66.7% vs 50%) were more common in azoospermic men. FSH levels are higher (18.7–23.2 mIU/L vs <0.1–8 mIU/L in non-azoospermia), testosterone is lower, and testis size are smaller (lower range 1 mL vs 10 mL) in men with azoospermia. Leydig cell tumours and hyperplasia were only detected in men with azoospermia. In summary, bilateral TT, GCNIS, higher tumour stage, smaller testes, SCO and history of UDT may have direct effects on spermatogenesis. Small testis, raised FSH and low testosterone may reflect reduced testicular function in azoospermic men. Performing a pre-orchidectomy semen analysis is important to identify those with azoospermia or severe oligospermia in order to plan for cryopreservation or onco-TESE in young men who wish to conceive. | - |
dc.language | eng | - |
dc.relation.ispartof | International Journal of Impotence Research | - |
dc.title | The relationship between testicular tumour characteristics and azoospermia: a systematic review | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1038/s41443-021-00492-x | - |
dc.identifier.pmid | 34743192 | - |
dc.identifier.scopus | eid_2-s2.0-85118618151 | - |
dc.identifier.volume | 34 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | 543 | - |
dc.identifier.epage | 551 | - |
dc.identifier.eissn | 1476-5489 | - |
dc.identifier.isi | WOS:000715010700002 | - |