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Article: Contribution of Epstein-Barr Virus Lytic Proteins to Cancer Hallmarks and Implications from Other Oncoviruses
| Title | Contribution of Epstein-Barr Virus Lytic Proteins to Cancer Hallmarks and Implications from Other Oncoviruses |
|---|---|
| Authors | |
| Keywords | cancer hallmarks Epstein–Barr virus (EBV) herpesvirus lytic proteins oncovirus |
| Issue Date | 2-Apr-2023 |
| Publisher | MDPI |
| Citation | Cancers, 2023, v. 15, n. 7 How to Cite? |
| Abstract | Epstein–Barr virus (EBV) is a prevalent human gamma-herpesvirus that infects the majority of the adult population worldwide and is associated with several lymphoid and epithelial malignancies. EBV displays a biphasic life cycle, namely, latent and lytic replication cycles, expressing a diversity of viral proteins. Among the EBV proteins being expressed during both latent and lytic cycles, the oncogenic roles of EBV lytic proteins are largely uncharacterized. In this review, the established contributions of EBV lytic proteins in tumorigenesis are summarized according to the cancer hallmarks displayed. We further postulate the oncogenic properties of several EBV lytic proteins by comparing the evolutionary conserved oncogenic mechanisms in other herpesviruses and oncoviruses. |
| Persistent Identifier | http://hdl.handle.net/10722/328966 |
| ISSN | 2023 Impact Factor: 4.5 2023 SCImago Journal Rankings: 1.391 |
| ISI Accession Number ID |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Dorothea, Mike | - |
| dc.contributor.author | Xie, Jia | - |
| dc.contributor.author | Yiu, Stephanie Pei Tung | - |
| dc.contributor.author | Chiang, Alan Kwok Shing | - |
| dc.date.accessioned | 2023-08-05T07:54:17Z | - |
| dc.date.available | 2023-08-05T07:54:17Z | - |
| dc.date.issued | 2023-04-02 | - |
| dc.identifier.citation | Cancers, 2023, v. 15, n. 7 | - |
| dc.identifier.issn | 2072-6694 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/328966 | - |
| dc.description.abstract | <p>Epstein–Barr virus (EBV) is a prevalent human gamma-herpesvirus that infects the majority of the adult population worldwide and is associated with several lymphoid and epithelial malignancies. EBV displays a biphasic life cycle, namely, latent and lytic replication cycles, expressing a diversity of viral proteins. Among the EBV proteins being expressed during both latent and lytic cycles, the oncogenic roles of EBV lytic proteins are largely uncharacterized. In this review, the established contributions of EBV lytic proteins in tumorigenesis are summarized according to the cancer hallmarks displayed. We further postulate the oncogenic properties of several EBV lytic proteins by comparing the evolutionary conserved oncogenic mechanisms in other herpesviruses and oncoviruses.</p> | - |
| dc.language | eng | - |
| dc.publisher | MDPI | - |
| dc.relation.ispartof | Cancers | - |
| dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
| dc.subject | cancer hallmarks | - |
| dc.subject | Epstein–Barr virus (EBV) | - |
| dc.subject | herpesvirus | - |
| dc.subject | lytic proteins | - |
| dc.subject | oncovirus | - |
| dc.title | Contribution of Epstein-Barr Virus Lytic Proteins to Cancer Hallmarks and Implications from Other Oncoviruses | - |
| dc.type | Article | - |
| dc.description.nature | published_or_final_version | - |
| dc.identifier.doi | 10.3390/cancers15072120 | - |
| dc.identifier.scopus | eid_2-s2.0-85152956316 | - |
| dc.identifier.volume | 15 | - |
| dc.identifier.issue | 7 | - |
| dc.identifier.eissn | 2072-6694 | - |
| dc.identifier.isi | WOS:000969350500001 | - |
| dc.identifier.issnl | 2072-6694 | - |