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- Publisher Website: 10.1111/crj.13624
- Scopus: eid_2-s2.0-85153725434
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Article: Blood eosinophil percentage as a predictor of response to inhaled corticosteroid in bronchiectasis
Title | Blood eosinophil percentage as a predictor of response to inhaled corticosteroid in bronchiectasis |
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Authors | |
Keywords | bronchiectasis bronchiectasis exacerbation eosinophil inhaled corticosteroid phenotype |
Issue Date | 26-Apr-2023 |
Publisher | Wiley Open Access |
Citation | The Clinical Respiratory Journal, 2023, v. 17, n. 6, p. 548-555 How to Cite? |
Abstract | IntroductionThe role of inhaled corticosteroid (ICS) among patients with bronchiectasis remains controversial. There is limited evidence of using baseline eosinophil count (absolute and percentage) as a marker to predict the role of ICS among patients with bronchiectasis. MethodsA retrospective case–control study was conducted in a major regional hospital and tertiary respiratory referral centre in Hong Kong, including 140 Chinese patients with noncystic fibrosis (CF) bronchiectasis, to investigate the exacerbation risks of bronchiectasis among ICS users and nonusers with different baseline eosinophil counts. ResultsICS user had significantly lower risk to develop bronchiectasis exacerbation with adjusted odds ratio (OR) of 0.461 (95% confidence interval [CI] 0.225–0.945, p-value 0.035). Univariate logistic regression was performed for different cut-offs of blood eosinophil count (by percentage) from 2% to 4% (with a 0.5% grid each time). Baseline eosinophil 3.5% was found to be the best cut-off among all with adjusted OR of 0.138 (95% CI = 0.023–0.822, p-value = 0.030). ConclusionBaseline eosinophil count of 3.5% might serve as a marker to predict the benefits of ICS on exacerbation risk among patients with non-CF bronchiectasis. |
Persistent Identifier | http://hdl.handle.net/10722/329008 |
ISSN | 2023 Impact Factor: 1.9 2023 SCImago Journal Rankings: 0.561 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Kwok, Wang Chun | - |
dc.contributor.author | Tam, Terence Chi Chun | - |
dc.contributor.author | Lam, David Chi Leung | - |
dc.contributor.author | Ip, Mary Sau Man | - |
dc.contributor.author | Ho, James Chung Man | - |
dc.date.accessioned | 2023-08-05T07:54:35Z | - |
dc.date.available | 2023-08-05T07:54:35Z | - |
dc.date.issued | 2023-04-26 | - |
dc.identifier.citation | The Clinical Respiratory Journal, 2023, v. 17, n. 6, p. 548-555 | - |
dc.identifier.issn | 1752-6981 | - |
dc.identifier.uri | http://hdl.handle.net/10722/329008 | - |
dc.description.abstract | <h3>Introduction</h3><p>The role of inhaled corticosteroid (ICS) among patients with bronchiectasis remains controversial. There is limited evidence of using baseline eosinophil count (absolute and percentage) as a marker to predict the role of ICS among patients with bronchiectasis.</p><h3>Methods</h3><p>A retrospective case–control study was conducted in a major regional hospital and tertiary respiratory referral centre in Hong Kong, including 140 Chinese patients with noncystic fibrosis (CF) bronchiectasis, to investigate the exacerbation risks of bronchiectasis among ICS users and nonusers with different baseline eosinophil counts.</p><h3>Results</h3><p>ICS user had significantly lower risk to develop bronchiectasis exacerbation with adjusted odds ratio (OR) of 0.461 (95% confidence interval [CI] 0.225–0.945, <em>p</em>-value 0.035). Univariate logistic regression was performed for different cut-offs of blood eosinophil count (by percentage) from 2% to 4% (with a 0.5% grid each time). Baseline eosinophil 3.5% was found to be the best cut-off among all with adjusted OR of 0.138 (95% CI = 0.023–0.822, <em>p</em>-value = 0.030).</p><h3>Conclusion</h3><p>Baseline eosinophil count of 3.5% might serve as a marker to predict the benefits of ICS on exacerbation risk among patients with non-CF bronchiectasis.</p> | - |
dc.language | eng | - |
dc.publisher | Wiley Open Access | - |
dc.relation.ispartof | The Clinical Respiratory Journal | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | bronchiectasis | - |
dc.subject | bronchiectasis exacerbation | - |
dc.subject | eosinophil | - |
dc.subject | inhaled corticosteroid | - |
dc.subject | phenotype | - |
dc.title | Blood eosinophil percentage as a predictor of response to inhaled corticosteroid in bronchiectasis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1111/crj.13624 | - |
dc.identifier.scopus | eid_2-s2.0-85153725434 | - |
dc.identifier.volume | 17 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | 548 | - |
dc.identifier.epage | 555 | - |
dc.identifier.eissn | 1752-699X | - |
dc.identifier.isi | WOS:000975154400001 | - |
dc.identifier.issnl | 1752-6981 | - |