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Article: Worsening of asthma control after recovery from mild to moderate COVID-19 in patients from Hong Kong

TitleWorsening of asthma control after recovery from mild to moderate COVID-19 in patients from Hong Kong
Authors
KeywordsAsthma
Asthma control
Asthma exacerbation
COVID-19
Issue Date14-Feb-2023
PublisherBioMed Central
Citation
Respiratory Research, 2023, v. 24, n. 1 How to Cite?
Abstract

Background

While there are postulations that asthma is potentially associated with severe coronavirus disease 2019 (COVID-19), there has been conflicting results from studies on the impact mild-to-moderate COVID-19 on asthma control after recovery.

Methods

A case control study on the association between mild-to-moderate COVID-19 and asthma control post infection was conducted. The primary outcome was a reduction in Asthma Control Test (ACT) score by ≥ 3 points post-COVID infection. The secondary outcomes included the change in ACT score, the proportion of patient with ACT score who dropped to ≤ 15 on enrolment visit and the need for escalation of asthma maintenance therapy.

Results

Out of the total of 221 adult patients with asthma recruited, 111 had mild-to-moderate COVID-19 within 30 to 270 days prior to study enrolment. The adjusted odds ratio (aOR) for a reduction in ACT score by ≥ 3 points after COVID-19 was 3.105 (95% CI = 1.385–6.959, p = 0.006). The odds of escalation of asthma maintenance therapy by at least 1 Global Initiative for Asthma (GINA) step was 4.733 (95% CI = 1.151–19.467, p = 0.031) and asthma patient are more likely to become uncontrolled after COVID-19 [aOR = 5.509 (95% CI = 1.061–28.600, p = 0.042)].

Conclusion

Mild-to-moderate COVID-19 among asthma patients, upon recovery, was associated with worsening of asthma symptom, lower ACT score, a higher need for escalation of asthma maintenance therapy and more uncontrolled asthma.


Persistent Identifierhttp://hdl.handle.net/10722/329012
ISSN
2010 Impact Factor: 2.859
2023 SCImago Journal Rankings: 1.498
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKwok, Wang Chun-
dc.contributor.authorTam, Terence Chi Chun-
dc.contributor.authorLam, David Chi Leung-
dc.contributor.authorLeung, Jackson Ka Chun-
dc.contributor.authorChan, King Pui Florence-
dc.contributor.authorChan, Shung Kay Samuel-
dc.contributor.authorChiang, Ka Yan-
dc.contributor.authorIp, Mary Sau Man-
dc.contributor.authorHo, James Chung Man-
dc.date.accessioned2023-08-05T07:54:36Z-
dc.date.available2023-08-05T07:54:36Z-
dc.date.issued2023-02-14-
dc.identifier.citationRespiratory Research, 2023, v. 24, n. 1-
dc.identifier.issn1465-9921-
dc.identifier.urihttp://hdl.handle.net/10722/329012-
dc.description.abstract<h3>Background</h3><p>While there are postulations that asthma is potentially associated with severe coronavirus disease 2019 (COVID-19), there has been conflicting results from studies on the impact mild-to-moderate COVID-19 on asthma control after recovery.</p><h3>Methods</h3><p>A case control study on the association between mild-to-moderate COVID-19 and asthma control post infection was conducted. The primary outcome was a reduction in Asthma Control Test (ACT) score by ≥ 3 points post-COVID infection. The secondary outcomes included the change in ACT score, the proportion of patient with ACT score who dropped to ≤ 15 on enrolment visit and the need for escalation of asthma maintenance therapy.</p><h3>Results</h3><p>Out of the total of 221 adult patients with asthma recruited, 111 had mild-to-moderate COVID-19 within 30 to 270 days prior to study enrolment. The adjusted odds ratio (aOR) for a reduction in ACT score by ≥ 3 points after COVID-19 was 3.105 (95% CI = 1.385–6.959, p = 0.006). The odds of escalation of asthma maintenance therapy by at least 1 Global Initiative for Asthma (GINA) step was 4.733 (95% CI = 1.151–19.467, p = 0.031) and asthma patient are more likely to become uncontrolled after COVID-19 [aOR = 5.509 (95% CI = 1.061–28.600, p = 0.042)].</p><h3>Conclusion</h3><p>Mild-to-moderate COVID-19 among asthma patients, upon recovery, was associated with worsening of asthma symptom, lower ACT score, a higher need for escalation of asthma maintenance therapy and more uncontrolled asthma.</p>-
dc.languageeng-
dc.publisherBioMed Central-
dc.relation.ispartofRespiratory Research-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectAsthma-
dc.subjectAsthma control-
dc.subjectAsthma exacerbation-
dc.subjectCOVID-19-
dc.titleWorsening of asthma control after recovery from mild to moderate COVID-19 in patients from Hong Kong-
dc.typeArticle-
dc.identifier.doi10.1186/s12931-023-02363-z-
dc.identifier.scopuseid_2-s2.0-85148082603-
dc.identifier.volume24-
dc.identifier.issue1-
dc.identifier.eissn1465-993X-
dc.identifier.isiWOS:000935533000002-
dc.identifier.issnl1465-9921-

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