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Article: Follicular helper T lymphocytes in the endometria of patients with reproductive failure: Association with pregnancy outcomes and inflammatory status of the endometria

TitleFollicular helper T lymphocytes in the endometria of patients with reproductive failure: Association with pregnancy outcomes and inflammatory status of the endometria
Authors
KeywordsB cells
chronic endometritis
helper T cells
reproductive failure
Tfh cells
Issue Date24-Apr-2023
PublisherAmerican Society for Reproductive Immunology
Citation
American Journal of Reproductive Immunology, 2023, v. 90 How to Cite?
Abstract

ProblemThe phenotypes and functions of B and CD4(+) T-helper cell subsets during chronic inflammation of the endometria remain largely unexplored. This study aimed to investigate the characteristics and functions of follicular helper T (Tfh) cells to understand the pathological mechanisms of chronic endometritis (CE). Method of studyEighty patients who underwent hysteroscopic and histopathological examinations for CE were divided into three groups-those with positive results for hysteroscopy and CD138 staining (DP), negative results for hysteroscopy but positive CD138 staining (SP), and negative results for hysteroscopy and CD138 staining (DN). The phenotypes of B cells and CD4(+) T-cell subsets were analyzed using flow cytometry. ResultsCD38(+) and CD138(+) cells were mainly expressed in the non-leukocyte population of the endometria, and the endometrial CD19(+)CD138(+) B cells were fewer than the CD3(+)CD138(+) T cells. The percentage of Tfh cells increased with chronic inflammation in the endometria. Additionally, the elevated percentage of Tfh cells correlated with the number of miscarriages. ConclusionsCD4(+) T cells, particularly Tfh cells, may be critical in chronic endometrial inflammation and affect its microenvironment, thereby regulating endometrial receptivity, compared to B cells.


Persistent Identifierhttp://hdl.handle.net/10722/329019
ISSN
2023 Impact Factor: 2.5
2023 SCImago Journal Rankings: 0.887
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTian, Y-
dc.contributor.authorZeng, QX-
dc.contributor.authorCheng, YF-
dc.contributor.authorWang, XH-
dc.contributor.authorCao, DD-
dc.contributor.authorYeung, WSB-
dc.contributor.authorLiu, QZ-
dc.contributor.authorDuan, YG-
dc.contributor.authorYao, YQ-
dc.date.accessioned2023-08-05T07:54:40Z-
dc.date.available2023-08-05T07:54:40Z-
dc.date.issued2023-04-24-
dc.identifier.citationAmerican Journal of Reproductive Immunology, 2023, v. 90-
dc.identifier.issn1046-7408-
dc.identifier.urihttp://hdl.handle.net/10722/329019-
dc.description.abstract<p> ProblemThe phenotypes and functions of B and CD4(+) T-helper cell subsets during chronic inflammation of the endometria remain largely unexplored. This study aimed to investigate the characteristics and functions of follicular helper T (Tfh) cells to understand the pathological mechanisms of chronic endometritis (CE). Method of studyEighty patients who underwent hysteroscopic and histopathological examinations for CE were divided into three groups-those with positive results for hysteroscopy and CD138 staining (DP), negative results for hysteroscopy but positive CD138 staining (SP), and negative results for hysteroscopy and CD138 staining (DN). The phenotypes of B cells and CD4(+) T-cell subsets were analyzed using flow cytometry. ResultsCD38(+) and CD138(+) cells were mainly expressed in the non-leukocyte population of the endometria, and the endometrial CD19(+)CD138(+) B cells were fewer than the CD3(+)CD138(+) T cells. The percentage of Tfh cells increased with chronic inflammation in the endometria. Additionally, the elevated percentage of Tfh cells correlated with the number of miscarriages. ConclusionsCD4(+) T cells, particularly Tfh cells, may be critical in chronic endometrial inflammation and affect its microenvironment, thereby regulating endometrial receptivity, compared to B cells. <br></p>-
dc.languageeng-
dc.publisherAmerican Society for Reproductive Immunology-
dc.relation.ispartofAmerican Journal of Reproductive Immunology-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectB cells-
dc.subjectchronic endometritis-
dc.subjecthelper T cells-
dc.subjectreproductive failure-
dc.subjectTfh cells-
dc.titleFollicular helper T lymphocytes in the endometria of patients with reproductive failure: Association with pregnancy outcomes and inflammatory status of the endometria-
dc.typeArticle-
dc.identifier.doi10.1111/aji.13708-
dc.identifier.scopuseid_2-s2.0-85153606561-
dc.identifier.volume90-
dc.identifier.eissn1600-0897-
dc.identifier.isiWOS:000973800800001-
dc.identifier.issnl1046-7408-

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