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Article: Ultrasensitive Detection of SARS‐CoV‑2 by Flexible Metal Oxide Field‐Effect Transistors

TitleUltrasensitive Detection of SARS‐CoV‑2 by Flexible Metal Oxide Field‐Effect Transistors
Authors
KeywordsCOVID-19
electrolyte-gated field-effect transistors
flexible biosensors
metal oxides
PEI doping
SARS-CoV-2 detections
Issue Date19-Jun-2023
PublisherWiley
Citation
Advanced Functional Materials, 2023 How to Cite?
Abstract

The pandemic of coronavirus disease 2019 (COVID-19) reflects the great significance of rapid and accurate detection of pathogens by new sensing technologies. Antibody based biosensors with high sensitivity comparable to golden standard polymerase chain reaction (PCR) and miniaturized device features allow the detection of pathogens in portable and flexible formats. Herein, flexible metal oxide electrolyte-gated field-effect transistors (EGFETs) are reported to serve as the biosensors for rapid and ultrasensitive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection. The semiconducting layer of the EGFETs associates with hybrid material of PEI doped metal oxides that not only improves the transistor performance, but also regulates microstructure forming higher surface-to-volume ratio, which brings more antibodies immobilization, resulting in higher sensitive, and faster response for detecting SARS-CoV-2. Comprehensive studies of materials and interfacing engineering of the EGFETs not only build the strong foundation for the EGFET sensors to show excellent sensitivity with a limit of detection from 0.14 fg ml−1 for SARS-CoV-2 S1 proteins, and 0.09 copies µl−1 for SARS-CoV-2 viruses, but also offer good mechanical properties to enable thin, soft flexible sensing platforms. This work provides a new strategy from materials to devices as innovative schemes for virus/pathogens detection.


Persistent Identifierhttp://hdl.handle.net/10722/329037
ISSN
2023 Impact Factor: 18.5
2023 SCImago Journal Rankings: 5.496
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHou, S-
dc.contributor.authorWu, M-
dc.contributor.authorLi, H-
dc.contributor.authorGong, HR-
dc.contributor.authorGao, Z-
dc.contributor.authorShi, R-
dc.contributor.authorHuang, X-
dc.contributor.authorLi, D-
dc.contributor.authorHuang, JD-
dc.contributor.authorYu, J-
dc.contributor.authorYu, X-
dc.date.accessioned2023-08-05T07:54:48Z-
dc.date.available2023-08-05T07:54:48Z-
dc.date.issued2023-06-19-
dc.identifier.citationAdvanced Functional Materials, 2023-
dc.identifier.issn1616-301X-
dc.identifier.urihttp://hdl.handle.net/10722/329037-
dc.description.abstract<p>The pandemic of coronavirus disease 2019 (COVID-19) reflects the great significance of rapid and accurate detection of pathogens by new sensing technologies. Antibody based biosensors with high sensitivity comparable to golden standard polymerase chain reaction (PCR) and miniaturized device features allow the detection of pathogens in portable and flexible formats. Herein, flexible metal oxide electrolyte-gated field-effect transistors (EGFETs) are reported to serve as the biosensors for rapid and ultrasensitive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection. The semiconducting layer of the EGFETs associates with hybrid material of PEI doped metal oxides that not only improves the transistor performance, but also regulates microstructure forming higher surface-to-volume ratio, which brings more antibodies immobilization, resulting in higher sensitive, and faster response for detecting SARS-CoV-2. Comprehensive studies of materials and interfacing engineering of the EGFETs not only build the strong foundation for the EGFET sensors to show excellent sensitivity with a limit of detection from 0.14 fg ml<sup>−1</sup> for SARS-CoV-2 S1 proteins, and 0.09 copies µl<sup>−1</sup> for SARS-CoV-2 viruses, but also offer good mechanical properties to enable thin, soft flexible sensing platforms. This work provides a new strategy from materials to devices as innovative schemes for virus/pathogens detection.<br></p>-
dc.languageeng-
dc.publisherWiley-
dc.relation.ispartofAdvanced Functional Materials-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectCOVID-19-
dc.subjectelectrolyte-gated field-effect transistors-
dc.subjectflexible biosensors-
dc.subjectmetal oxides-
dc.subjectPEI doping-
dc.subjectSARS-CoV-2 detections-
dc.titleUltrasensitive Detection of SARS‐CoV‑2 by Flexible Metal Oxide Field‐Effect Transistors-
dc.typeArticle-
dc.identifier.doi10.1002/adfm.202301268-
dc.identifier.scopuseid_2-s2.0-85162233328-
dc.identifier.eissn1616-3028-
dc.identifier.isiWOS:001010509000001-
dc.identifier.issnl1616-301X-

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