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Article: Hydrogel-Forming Microneedles with Applications in Oral Diseases Management

TitleHydrogel-Forming Microneedles with Applications in Oral Diseases Management
Authors
Keywordsdrug administration routes
drug delivery systems
drug implants
hydrogels
Issue Date3-Jul-2023
PublisherMDPI
Citation
Materials, 2023, v. 16, n. 13 How to Cite?
Abstract

Controlled drug delivery in the oral cavity poses challenges such as bacterial contamination, saliva dilution, and inactivation by salivary enzymes upon ingestion. Microneedles offer a location-specific, minimally invasive, and retentive approach. Hydrogel-forming microneedles (HFMs) have emerged for dental diagnostics and therapeutics. HFMs penetrate the stratum corneum, undergo swelling upon contact, secure attachment, and enable sustained transdermal or transmucosal drug delivery. Commonly employed polymers such as polyvinyl alcohol (PVA) and polyvinyl pyrrolidone are crosslinked with tartaric acid or its derivatives while incorporating therapeutic agents. Microneedle patches provide suture-free and painless drug delivery to keratinized or non-keratinized mucosa, facilitating site-specific treatment and patient compliance. This review comprehensively discusses HFMs’ applications in dentistry such as local anesthesia, oral ulcer management, periodontal treatment, etc., encompassing animal experiments, clinical trials, and their fundamental impact and limitations, for example, restricted drug carrying capacity and, until now, a low number of dental clinical trial reports. The review explores the advantages and future perspectives of HFMs for oral drug delivery.


Persistent Identifierhttp://hdl.handle.net/10722/329110
ISSN
2021 Impact Factor: 3.748
2020 SCImago Journal Rankings: 0.682
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, Yuqing-
dc.contributor.authorBi, Duohang-
dc.contributor.authorHu, Zhekai-
dc.contributor.authorYang, Yanqi-
dc.contributor.authorLiu, Yijing-
dc.contributor.authorLeung, Wai Keung-
dc.date.accessioned2023-08-05T07:55:22Z-
dc.date.available2023-08-05T07:55:22Z-
dc.date.issued2023-07-03-
dc.identifier.citationMaterials, 2023, v. 16, n. 13-
dc.identifier.issn1996-1944-
dc.identifier.urihttp://hdl.handle.net/10722/329110-
dc.description.abstract<p>Controlled drug delivery in the oral cavity poses challenges such as bacterial contamination, saliva dilution, and inactivation by salivary enzymes upon ingestion. Microneedles offer a location-specific, minimally invasive, and retentive approach. Hydrogel-forming microneedles (HFMs) have emerged for dental diagnostics and therapeutics. HFMs penetrate the stratum corneum, undergo swelling upon contact, secure attachment, and enable sustained transdermal or transmucosal drug delivery. Commonly employed polymers such as polyvinyl alcohol (PVA) and polyvinyl pyrrolidone are crosslinked with tartaric acid or its derivatives while incorporating therapeutic agents. Microneedle patches provide suture-free and painless drug delivery to keratinized or non-keratinized mucosa, facilitating site-specific treatment and patient compliance. This review comprehensively discusses HFMs’ applications in dentistry such as local anesthesia, oral ulcer management, periodontal treatment, etc., encompassing animal experiments, clinical trials, and their fundamental impact and limitations, for example, restricted drug carrying capacity and, until now, a low number of dental clinical trial reports. The review explores the advantages and future perspectives of HFMs for oral drug delivery.</p>-
dc.languageeng-
dc.publisherMDPI-
dc.relation.ispartofMaterials-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectdrug administration routes-
dc.subjectdrug delivery systems-
dc.subjectdrug implants-
dc.subjecthydrogels-
dc.titleHydrogel-Forming Microneedles with Applications in Oral Diseases Management-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3390/ma16134805-
dc.identifier.scopuseid_2-s2.0-85164794756-
dc.identifier.volume16-
dc.identifier.issue13-
dc.identifier.eissn1996-1944-
dc.identifier.isiWOS:001028575600001-
dc.identifier.issnl1996-1944-

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