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Article: Realizing Highly Efficient Sonodynamic Bactericidal Capability through the Phonon-Electron Coupling Effect Using Two-Dimensional Catalytic Planar Defects

TitleRealizing Highly Efficient Sonodynamic Bactericidal Capability through the Phonon-Electron Coupling Effect Using Two-Dimensional Catalytic Planar Defects
Authors
Keywordsactivation energy
phonon–electron coupling
Schottky defects
sonodynamic therapy
two-dimensional catalytic planar defects
Issue Date9-Jan-2023
PublisherWiley
Citation
Advanced Materials, 2023, v. 35, n. 9 How to Cite?
Abstract

Conferring catalytic defects in sonosensitizers is of paramount importance in reinforcing sonodynamic therapy. However, the formation of such zero-dimensional (0D) defects is governed by the Schottky defect principle. We herein design two-dimensional (2D) catalytic planar defects within Ti3C2 sheets to address this challenge. These specific planar slip dislocations with abundant Ti3+ species [Ti3C2-SD(Ti3+)] can yield surface-bound O due to the effective activation of O2, thus resulting in a substantial amount of 1O2 generation and the 99.72% ± 0.03% bactericidal capability subject to ultrasound (US) stimulation. We discover that the 2D catalytic planar defects can intervene electron transfer through the phonon drag effect – a coupling effect between surface electrons and US-triggered phonons – that simultaneously contributes to a dramatic decrease in O2 activation energy from 1.65 to 0.06 eV. Our design has achieved a qualitative leap in which the US catalytic site has transformed from 0D to 2D. Moreover, we reveal that the electron origin, electron transfer, and visible O2 activation pathway triggered by US can be attributed to the phonon–electron coupling effect. After coated with neutrophil membrane (NM) proteins, the NM-Ti3C2-SD(Ti3+) sheets further demonstrate a 6-log10 reduction in methicillin-resistant Staphylococcus aureus burden in the infected bony tissue.


Persistent Identifierhttp://hdl.handle.net/10722/329119
ISSN
2023 Impact Factor: 27.4
2023 SCImago Journal Rankings: 9.191
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMao, Congyang-
dc.contributor.authorJin, Wanyu-
dc.contributor.authorXiang, Yiming-
dc.contributor.authorZhu, Yizhou-
dc.contributor.authorWu, Jun-
dc.contributor.authorLiu, Xiangmei-
dc.contributor.authorWu, Shuilin-
dc.contributor.authorZheng, Yufeng-
dc.contributor.authorCheung, Kenneth-
dc.contributor.authorYeung, Kelvin Wai Kwok-
dc.date.accessioned2023-08-05T07:55:26Z-
dc.date.available2023-08-05T07:55:26Z-
dc.date.issued2023-01-09-
dc.identifier.citationAdvanced Materials, 2023, v. 35, n. 9-
dc.identifier.issn0935-9648-
dc.identifier.urihttp://hdl.handle.net/10722/329119-
dc.description.abstract<p>Conferring catalytic defects in sonosensitizers is of paramount importance in reinforcing sonodynamic therapy. However, the formation of such zero-dimensional (0D) defects is governed by the Schottky defect principle. We herein design two-dimensional (2D) catalytic planar defects within Ti<sub>3</sub>C<sub>2</sub> sheets to address this challenge. These specific planar slip dislocations with abundant Ti<sup>3+</sup> species [Ti<sub>3</sub>C<sub>2</sub>-SD(Ti<sup>3+</sup>)] can yield surface-bound O due to the effective activation of O<sub>2</sub>, thus resulting in a substantial amount of <sup>1</sup>O<sub>2 </sub>generation and the 99.72% ± 0.03% bactericidal capability subject to ultrasound (US) stimulation. We discover that the 2D catalytic planar defects can intervene electron transfer through the phonon drag effect – a coupling effect between surface electrons and US-triggered phonons – that simultaneously contributes to a dramatic decrease in O<sub>2</sub> activation energy from 1.65 to 0.06 eV. Our design has achieved a qualitative leap in which the US catalytic site has transformed from 0D to 2D. Moreover, we reveal that the electron origin, electron transfer, and visible O<sub>2</sub> activation pathway triggered by US can be attributed to the phonon–electron coupling effect. After coated with neutrophil membrane (NM) proteins, the NM-Ti<sub>3</sub>C<sub>2</sub>-SD(Ti<sup>3+</sup>) sheets further demonstrate a 6-log<sub>10</sub> reduction in methicillin-resistant <em>Staphylococcus aureus</em> burden in the infected bony tissue.</p>-
dc.languageeng-
dc.publisherWiley-
dc.relation.ispartofAdvanced Materials-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectactivation energy-
dc.subjectphonon–electron coupling-
dc.subjectSchottky defects-
dc.subjectsonodynamic therapy-
dc.subjecttwo-dimensional catalytic planar defects-
dc.titleRealizing Highly Efficient Sonodynamic Bactericidal Capability through the Phonon-Electron Coupling Effect Using Two-Dimensional Catalytic Planar Defects-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1002/adma.202208681-
dc.identifier.scopuseid_2-s2.0-85146162889-
dc.identifier.volume35-
dc.identifier.issue9-
dc.identifier.eissn1521-4095-
dc.identifier.isiWOS:000913784500001-
dc.identifier.issnl0935-9648-

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