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Article: Risk of air and surface contamination during application of different noninvasive respiratory support for patients with COVID-19

TitleRisk of air and surface contamination during application of different noninvasive respiratory support for patients with COVID-19
Authors
KeywordsAir
HFNC
NIV
Oxygen therapy
Surface sampling
Issue Date12-May-2023
PublisherElsevier
Citation
International Journal of Infectious Diseases, 2023, v. 133, p. 60-66 How to Cite?
Abstract

Objectives

We compared the risk of environmental contamination among patients with COVID-19 who received high-flow nasal cannula (HFNC), noninvasive ventilation (NIV), and conventional oxygen therapy (COT) via nasal cannula for respiratory failure.

Methods

Air was sampled from the hospital isolation rooms with 12 air changes/hr where 26 patients with COVID-19 received HFNC (up to 60 l/min, n = 6), NIV (n = 6), or COT (up to 5 l/min of oxygen, n = 14). Surface samples were collected from 16 patients during air sampling.

Results

Viral RNA was detected at comparable frequency in air samples collected from patients receiving HFNC (3/54, 5.6%), NIV (1/54, 1.9%), and COT (4/117, 3.4%) (P = 0.579). Similarly, the risk of surface contamination was comparable among patients receiving HFNC (3/46, 6.5%), NIV (14/72, 19.4%), and COT (8/59, 13.6%) (P = 0.143). An increment in the cyclic thresholds of the upper respiratory specimen prior to air sampling was associated with a reduced SARS-CoV-2 detection risk in air (odds ratio 0.83 [95% confidence interval 0.69-0.96], P = 0.027) by univariate logistic regression.

Conclusion

No increased risk of environmental contamination in the isolation rooms was observed in the use of HFNC and NIV vs COT among patients with COVID-19 with respiratory failure. Higher viral load in the respiratory samples was associated with positive air samples.


Persistent Identifierhttp://hdl.handle.net/10722/329140
ISSN
2023 Impact Factor: 4.8
2023 SCImago Journal Rankings: 1.435
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHui, David-
dc.contributor.authorYung, Louise-
dc.contributor.authorChan, Ken-
dc.contributor.authorNg, Susanna-
dc.contributor.authorLui, Grace-
dc.contributor.authorKo, Fanny-
dc.contributor.authorChan, Tat On-
dc.contributor.authorYiu, Karen-
dc.contributor.authorLi, Yuguo-
dc.contributor.authorChan, Matthew-
dc.contributor.authorYen, Hui Ling-
dc.date.accessioned2023-08-05T07:55:36Z-
dc.date.available2023-08-05T07:55:36Z-
dc.date.issued2023-05-12-
dc.identifier.citationInternational Journal of Infectious Diseases, 2023, v. 133, p. 60-66-
dc.identifier.issn1201-9712-
dc.identifier.urihttp://hdl.handle.net/10722/329140-
dc.description.abstract<h3>Objectives</h3><p>We compared the risk of environmental contamination among patients with COVID-19 who received high-flow nasal cannula (HFNC), noninvasive ventilation (NIV), and conventional oxygen therapy (COT) via nasal cannula for respiratory failure.</p><h3>Methods</h3><p>Air was sampled from the hospital isolation rooms with 12 air changes/hr where 26 patients with COVID-19 received HFNC (up to 60 l/min, n = 6), NIV (n = 6), or COT (up to 5 l/min of oxygen, n = 14). Surface samples were collected from 16 patients during air sampling.</p><h3>Results</h3><p>Viral RNA was detected at comparable frequency in air samples collected from patients receiving HFNC (3/54, 5.6%), NIV (1/54, 1.9%), and COT (4/117, 3.4%) (<em>P</em> = 0.579). Similarly, the risk of surface contamination was comparable among patients receiving HFNC (3/46, 6.5%), NIV (14/72, 19.4%), and COT (8/59, 13.6%) (<em>P</em> = 0.143). An increment in the cyclic thresholds of the upper respiratory specimen prior to air sampling was associated with a reduced SARS-CoV-2 detection risk in air (odds ratio 0.83 [95% confidence interval 0.69-0.96], <em>P</em> = 0.027) by univariate logistic regression.</p><h3>Conclusion</h3><p>No increased risk of environmental contamination in the isolation rooms was observed in the use of HFNC and NIV vs COT among patients with COVID-19 with respiratory failure. Higher viral load in the respiratory samples was associated with positive air samples.</p>-
dc.languageeng-
dc.publisherElsevier-
dc.relation.ispartofInternational Journal of Infectious Diseases-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectAir-
dc.subjectHFNC-
dc.subjectNIV-
dc.subjectOxygen therapy-
dc.subjectSurface sampling-
dc.titleRisk of air and surface contamination during application of different noninvasive respiratory support for patients with COVID-19-
dc.typeArticle-
dc.identifier.doi10.1016/j.ijid.2023.05.008-
dc.identifier.scopuseid_2-s2.0-85160436543-
dc.identifier.volume133-
dc.identifier.spage60-
dc.identifier.epage66-
dc.identifier.isiWOS:001013331200001-
dc.identifier.issnl1201-9712-

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