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Article: ST36 acupoint injection with anisodamine for postoperative nausea and vomiting in female patients after bariatric surgery: a prospective, randomized controlled trial

TitleST36 acupoint injection with anisodamine for postoperative nausea and vomiting in female patients after bariatric surgery: a prospective, randomized controlled trial
Authors
KeywordsAnisodamine
Laparoscopic sleeve gastrectomy
Multimodal antiemetic prophylaxis
Postoperative nausea and vomiting
ST36 acupoint
Issue Date24-Apr-2023
PublisherSpringer
Citation
Surgical Endoscopy, 2023, v. 37, n. 8, p. 5999-6007 How to Cite?
Abstract

Background:  The use of multimodal pharmacological prophylactic regimes has decreased postoperative nausea and vomiting(PONV) in general but it still occurs in over 60% of female patients after bariatric surgery. This study aimed to evaluate the efficacy of ST36 acupoint injection with anisodamine in prevention of PONV among female patients after bariatric surgery.

Methods: Ninety patients undergoing laparoscopic sleeve gastrectomy were randomly allocated to anisodamine or control group at the ratio of 2:1. Anisodamine or normal saline was injected into Zusanli (ST36) bilaterally after induction of general anesthesia. The incidence and severity of PONV were assessed during the first 3 postoperative days and at 3 months. The quality of early recovery of anesthesia, gastrointestinal function, sleep quality, anxiety, depression, and complications were also evaluated.

Results: Baseline and perioperative characteristics were comparable between two groups. In the anisodamine group, 25 patients (42.4%) experienced vomiting within postoperative 24 h compared with 21 (72.4%) in the control group (relative risk 0.59; 95% confidence interval 0.40–0.85). Time to first rescue antiemetic was 6.5 h in anisodamine group, and 1.7 h in

the control group (P = 0.011). Less rescue antiemetic was required during the first 24 h in the anisodamine group (P = 0.024). There were no differences in either postoperative nausea or other recovery characteristics.

Conclusions:  The addition of ST36 acupoint injection with anisodamine significantly reduced postoperative vomiting without affecting nausea in female patients with obesity undergoing laparoscopic sleeve gastrectomy.


Persistent Identifierhttp://hdl.handle.net/10722/329215
ISSN
2023 Impact Factor: 2.4
2023 SCImago Journal Rankings: 1.120
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorXue, Q-
dc.contributor.authorXing, QJ-
dc.contributor.authorDong, L-
dc.contributor.authorGuo, M-
dc.contributor.authorZhang, XY-
dc.contributor.authorWei, XC-
dc.contributor.authorJia, BL-
dc.contributor.authorWang, Y-
dc.contributor.authorChen, H-
dc.contributor.authorHu, XW-
dc.contributor.authorLiu, H-
dc.contributor.authorZhang, Y-
dc.contributor.authorWong, GTC-
dc.contributor.authorHuang, CX -
dc.date.accessioned2023-08-05T07:56:10Z-
dc.date.available2023-08-05T07:56:10Z-
dc.date.issued2023-04-24-
dc.identifier.citationSurgical Endoscopy, 2023, v. 37, n. 8, p. 5999-6007-
dc.identifier.issn0930-2794-
dc.identifier.urihttp://hdl.handle.net/10722/329215-
dc.description.abstract<p>Background:  The use of multimodal pharmacological prophylactic regimes has decreased postoperative nausea and vomiting(PONV) in general but it still occurs in over 60% of female patients after bariatric surgery. This study aimed to evaluate the efficacy of ST36 acupoint injection with anisodamine in prevention of PONV among female patients after bariatric surgery.<br></p><p>Methods: Ninety patients undergoing laparoscopic sleeve gastrectomy were randomly allocated to anisodamine or control group at the ratio of 2:1. Anisodamine or normal saline was injected into Zusanli (ST36) bilaterally after induction of general anesthesia. The incidence and severity of PONV were assessed during the first 3 postoperative days and at 3 months. The quality of early recovery of anesthesia, gastrointestinal function, sleep quality, anxiety, depression, and complications were also evaluated.<br></p><p>Results: Baseline and perioperative characteristics were comparable between two groups. In the anisodamine group, 25 patients (42.4%) experienced vomiting within postoperative 24 h compared with 21 (72.4%) in the control group (relative risk 0.59; 95% confidence interval 0.40–0.85). Time to first rescue antiemetic was 6.5 h in anisodamine group, and 1.7 h in</p><p>the control group (P = 0.011). Less rescue antiemetic was required during the first 24 h in the anisodamine group (P = 0.024). There were no differences in either postoperative nausea or other recovery characteristics.<br></p><p>Conclusions:  The addition of ST36 acupoint injection with anisodamine significantly reduced postoperative vomiting without affecting nausea in female patients with obesity undergoing laparoscopic sleeve gastrectomy.</p>-
dc.languageeng-
dc.publisherSpringer-
dc.relation.ispartofSurgical Endoscopy-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectAnisodamine-
dc.subjectLaparoscopic sleeve gastrectomy-
dc.subjectMultimodal antiemetic prophylaxis-
dc.subjectPostoperative nausea and vomiting-
dc.subjectST36 acupoint-
dc.titleST36 acupoint injection with anisodamine for postoperative nausea and vomiting in female patients after bariatric surgery: a prospective, randomized controlled trial-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1007/s00464-023-10037-6-
dc.identifier.scopuseid_2-s2.0-85153339985-
dc.identifier.volume37-
dc.identifier.issue8-
dc.identifier.spage5999-
dc.identifier.epage6007-
dc.identifier.eissn1432-2218-
dc.identifier.isiWOS:000974771400003-
dc.identifier.issnl0930-2794-

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