Corrigendum to “Late-breaking abstracts” [Int. J. Psychophysiol. volume 168, supplement, October 2021, page S223–233] (International Journal of Psychophysiology (2021) 168(S), (S0167876021008059))

Abstract

We, the organizing committee for the International Organization of Psychophysiology 20th World Congress, regret that not all authors were listed on the initial publication of the following late-breaking poster presentations. The corrigendum represents the corrected abstracts with all authors listed. The Relationship Between Amygdala - Insula Functional Connectivity and Childhood Trauma and Depression Lizhu Luoa,*, Ting Yanga, Xiaoxiao Zhenga, Qiyuan Lina, Yunge Lia, Benjamin Beckera, Keith KendrickaaThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for NeuroInformation, University of Electronic Science and Technology of China ⁎Presenter. Background: Childhood trauma has been significantly associated with the prevalence of mental disorders in adulthood such as depression and altered brain structure and function particularly in limbic systems such as amygdala engaged in emotional processing and regulation. The present study aimed at exploring the association between childhood trauma and amygdala-based emotional network, and the relevant effect on depression. Methods: A total of 90 subjects (47 males, age range = 18-27 years, M ± SD = 21.71 ± 2.24) participated in the present resting state fMRI study in a 3T GE Discovery MR750 scanner. Levels of childhood trauma and depression were assessed using Childhood Trauma Questionnaire (CTQ) and Beck Depression Inventory (BDI-II) separately. Resting-state fMRI data analyses were conducted using SPM12 based on Matlab (R2014b). ROI-to-ROI approach was employed within the following regions: bilateral hippocampus (HIP), insula (INS), medial orbitofrontal cortex (mOFC), anterior cingulate gyrus (ACC), precuneus (PCU) and putamen (PUT). Multiple regression analyses were conducted to evaluate associations between CTQ and FC of amygdala, controlling for gender and age. Results were shown with small volume correction (kN = 10, pb0.05, FWE corrected). Results: The CTQ total scores were significantly correlated with the decreased functional connectivity between left amygdala and left anterior insula (k = 16, t = 3.89, p = 0.012, x/y/z: −36/6/−15; t = 3.78, p = 0.017, x/y/z: −33/9/−18), and between left CMA and left anterior INS (k = 18, t = 4.06,p = 0.007, x/y/z: −42/6/−12), controlling the effect of age and gender. The permutation test revealed a significant negative association between CTQ total scores and the FC of left AMY-INS (pb0.001, r = −0.382) and that of left CMA-INS (pb0.001, r = −0.36). Further analyses showed a significant negative correlation between FC of left CMA-INS and emotional abuse (p = 0.021, r = −0.229), controlling the effect of the other four CTQ subtypes, age and gender. The moderation analysis revealed a significant moderation effect (R2 = 0.09, F3,86 = 3.06, p = 0.03), reflecting that the interaction between functional connectivity of left CMA-INS and CTQ total scores significantly predicted the level of depression (B = 0.89, S.E. = 0.38, t86 = 2.36, p = 0.02). Conclusions: The present findings reflect a negative association between childhood trauma and amygdala-insula circuit, specifically between childhood emotional abuse and the central medial amygdala-insula functional connectivity, which then interactively predicts the level of depression. -Supported by the National Natural Science Foundation of China (31800961); the Project of Science and Technology Department of Sichuan Province (2018JY0361; 2020ZYD013). -Correspondence: Lizhu Luo, luolizhu@uestc.edu.cn