File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1162/jocn_a_00383
- Scopus: eid_2-s2.0-84878400011
- WOS: WOS:000319735800001
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Nicotinic acetylcholine receptors contribute to learning-induced Metaplasticity in the hippocampus
Title | Nicotinic acetylcholine receptors contribute to learning-induced Metaplasticity in the hippocampus |
---|---|
Authors | |
Issue Date | 2013 |
Citation | Journal of Cognitive Neuroscience, 2013, v. 25, n. 7, p. 986-997 How to Cite? |
Abstract | Hippocampal learning is thought to induce metaplasticity, which can facilitate subsequent learning. Administered at single low doses, the N-methyl-D-aspartate-type glutamate receptor antagonist memantine predominantly blocks α7 nicotinic acetyl-choline receptors (α7 nAChRs). Placebo-controlled administration of a single low dose of memantine in a pharmaco-fMRI experiment may thus help characterize the role of α7 nAChRs in hippocampal metaplasticity. We hypothesized that if α7 nAChRs contribute to learning-induced metaplasticity in the hippocampus, blockade of these receptors with low-dose memantine would selectively interfere with a facilitation of subsequent learning without impairing hippocampal learning per se. To specifically test this hypothesis, we devised a randomized controlled trial in which healthy volunteers were administered a 20-mg single oral dose of meman-tine or placebo and scanned on three subsequent runs of a hippo-campal learning task. Our results indicate no discrepancies in behavioral learning between low-dose memantine- and placebo-treated participants in the first and second run of this task. In the third run, however, only the placebo-treated group showed facilitated behavioral learning, an effect paralleled by decreased neural responses in the hippocampal cornu ammonis region. Our findings suggest that blockade of α7 nAChRs selectively interfered with a learning-induced facilitation of subsequent learning while leaving unimpaired hippocampal learning per se. Taken together, our results provide support for a relevant contribution of α7 nAChRs to learning-associated metaplasticity in the hippocampus. © 2013 Massachusetts Institute of Technology. |
Persistent Identifier | http://hdl.handle.net/10722/330512 |
ISSN | 2023 Impact Factor: 3.1 2023 SCImago Journal Rankings: 1.402 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Becker, Benjamin | - |
dc.contributor.author | Klein, Eva M. | - |
dc.contributor.author | Striepens, Nadine | - |
dc.contributor.author | Mihov, Yoan | - |
dc.contributor.author | Schlaepfer, Thomas E. | - |
dc.contributor.author | Reul, Juergen | - |
dc.contributor.author | Goossens, Liesbet | - |
dc.contributor.author | Schruers, Koen | - |
dc.contributor.author | Kendrick, Keith M. | - |
dc.contributor.author | Hurlemann, René | - |
dc.date.accessioned | 2023-09-05T12:11:20Z | - |
dc.date.available | 2023-09-05T12:11:20Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Journal of Cognitive Neuroscience, 2013, v. 25, n. 7, p. 986-997 | - |
dc.identifier.issn | 0898-929X | - |
dc.identifier.uri | http://hdl.handle.net/10722/330512 | - |
dc.description.abstract | Hippocampal learning is thought to induce metaplasticity, which can facilitate subsequent learning. Administered at single low doses, the N-methyl-D-aspartate-type glutamate receptor antagonist memantine predominantly blocks α7 nicotinic acetyl-choline receptors (α7 nAChRs). Placebo-controlled administration of a single low dose of memantine in a pharmaco-fMRI experiment may thus help characterize the role of α7 nAChRs in hippocampal metaplasticity. We hypothesized that if α7 nAChRs contribute to learning-induced metaplasticity in the hippocampus, blockade of these receptors with low-dose memantine would selectively interfere with a facilitation of subsequent learning without impairing hippocampal learning per se. To specifically test this hypothesis, we devised a randomized controlled trial in which healthy volunteers were administered a 20-mg single oral dose of meman-tine or placebo and scanned on three subsequent runs of a hippo-campal learning task. Our results indicate no discrepancies in behavioral learning between low-dose memantine- and placebo-treated participants in the first and second run of this task. In the third run, however, only the placebo-treated group showed facilitated behavioral learning, an effect paralleled by decreased neural responses in the hippocampal cornu ammonis region. Our findings suggest that blockade of α7 nAChRs selectively interfered with a learning-induced facilitation of subsequent learning while leaving unimpaired hippocampal learning per se. Taken together, our results provide support for a relevant contribution of α7 nAChRs to learning-associated metaplasticity in the hippocampus. © 2013 Massachusetts Institute of Technology. | - |
dc.language | eng | - |
dc.relation.ispartof | Journal of Cognitive Neuroscience | - |
dc.title | Nicotinic acetylcholine receptors contribute to learning-induced Metaplasticity in the hippocampus | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1162/jocn_a_00383 | - |
dc.identifier.scopus | eid_2-s2.0-84878400011 | - |
dc.identifier.volume | 25 | - |
dc.identifier.issue | 7 | - |
dc.identifier.spage | 986 | - |
dc.identifier.epage | 997 | - |
dc.identifier.eissn | 1530-8898 | - |
dc.identifier.isi | WOS:000319735800001 | - |