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Article: Sex-dependent neural effect of oxytocin during subliminal processing of negative emotion faces

TitleSex-dependent neural effect of oxytocin during subliminal processing of negative emotion faces
Authors
KeywordsAnxiety
Cingulate cortex
Face emotion
Inferior frontal gyrus
Oxytocin
Sex difference
Issue Date2017
Citation
NeuroImage, 2017, v. 162, p. 127-137 How to Cite?
AbstractIn line with animal models indicating sexually dimorphic effects of oxytocin (OXT) on social-emotional processing, a growing number of OXT-administration studies in humans have also reported sex-dependent effects during social information processing. To explore whether sex-dependent effects already occur during early, subliminal, processing stages the present pharmacological fMRI-study combined the intranasal-application of either OXT or placebo (n = 86–43 males) with a backward-masking emotional face paradigm. Results showed that while OXT suppressed inferior frontal gyrus, dorsal anterior cingulate and anterior insula responses to threatening face stimuli in men it increased them in women. In women increased anterior cingulate reactivity during subliminal threat processing was also positively associated with trait anxiety. On the network level, sex-dependent effects were observed on amygdala, anterior cingulate and inferior frontal gyrus functional connectivity that were mainly driven by reduced coupling in women following OXT. Our findings demonstrate that OXT produces sex-dependent effects even at the early stages of social-emotional processing, and suggest that while it attenuates neural responses to threatening social stimuli in men it increases them in women. Thus in a therapeutic context OXT may potentially produce different effects on anxiety disorders in men and women.
Persistent Identifierhttp://hdl.handle.net/10722/330552
ISSN
2023 Impact Factor: 4.7
2023 SCImago Journal Rankings: 2.436
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLuo, Lizhu-
dc.contributor.authorBecker, Benjamin-
dc.contributor.authorGeng, Yayuan-
dc.contributor.authorZhao, Zhiying-
dc.contributor.authorGao, Shan-
dc.contributor.authorZhao, Weihua-
dc.contributor.authorYao, Shuxia-
dc.contributor.authorZheng, Xiaoxiao-
dc.contributor.authorMa, Xiaole-
dc.contributor.authorGao, Zhao-
dc.contributor.authorHu, Jiehui-
dc.contributor.authorKendrick, Keith M.-
dc.date.accessioned2023-09-05T12:11:43Z-
dc.date.available2023-09-05T12:11:43Z-
dc.date.issued2017-
dc.identifier.citationNeuroImage, 2017, v. 162, p. 127-137-
dc.identifier.issn1053-8119-
dc.identifier.urihttp://hdl.handle.net/10722/330552-
dc.description.abstractIn line with animal models indicating sexually dimorphic effects of oxytocin (OXT) on social-emotional processing, a growing number of OXT-administration studies in humans have also reported sex-dependent effects during social information processing. To explore whether sex-dependent effects already occur during early, subliminal, processing stages the present pharmacological fMRI-study combined the intranasal-application of either OXT or placebo (n = 86–43 males) with a backward-masking emotional face paradigm. Results showed that while OXT suppressed inferior frontal gyrus, dorsal anterior cingulate and anterior insula responses to threatening face stimuli in men it increased them in women. In women increased anterior cingulate reactivity during subliminal threat processing was also positively associated with trait anxiety. On the network level, sex-dependent effects were observed on amygdala, anterior cingulate and inferior frontal gyrus functional connectivity that were mainly driven by reduced coupling in women following OXT. Our findings demonstrate that OXT produces sex-dependent effects even at the early stages of social-emotional processing, and suggest that while it attenuates neural responses to threatening social stimuli in men it increases them in women. Thus in a therapeutic context OXT may potentially produce different effects on anxiety disorders in men and women.-
dc.languageeng-
dc.relation.ispartofNeuroImage-
dc.subjectAnxiety-
dc.subjectCingulate cortex-
dc.subjectFace emotion-
dc.subjectInferior frontal gyrus-
dc.subjectOxytocin-
dc.subjectSex difference-
dc.titleSex-dependent neural effect of oxytocin during subliminal processing of negative emotion faces-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.neuroimage.2017.08.079-
dc.identifier.pmid28877512-
dc.identifier.scopuseid_2-s2.0-85028746477-
dc.identifier.volume162-
dc.identifier.spage127-
dc.identifier.epage137-
dc.identifier.eissn1095-9572-
dc.identifier.isiWOS:000416502800013-

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