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Article: Neural networks during delay discounting as trans-disease marker: A meta-analytical review

TitleNeural networks during delay discounting as trans-disease marker: A meta-analytical review
Authors
KeywordsADHD
Meta-analysis
NeuroImaging
Trans-disease process
Triple network system
Issue Date2021
Citation
Journal of Psychiatric Research, 2021, v. 139, p. 62-70 How to Cite?
AbstractDelay discounting reflects a devaluation of delayed long-term benefits but pursuing immediate rewards. Higher discounting rates (h-DR) are found ubiquitous in many diseases and unhealthy conditions, particularly in addiction disorder (AD), attention-deficit/hyperactivity disorder (ADHD), and obesity. Thus, h-DR was considered to be a common benchmark across many diseases facilitating to understand one disease to relevant others, which was called trans-disease process. However, the common and specific neural biomarkers associated with this process has not yet been studied well. We performed a voxel-wise task-related neuroimaging meta-analysis to clarify the neural pattern of trans-disease process across AD, ADHD and obesity. We recruited 19 eligible papers, including 9 AD papers (154 patients), 6 ADHD papers (106 patients) and 4 obesity studies (94 patients). Neuroimaging meta-analysis demonstrated the presence of neural biomarkers of trans-disease process: these patients showed inadequate brain response in caudate, ventromedial and dorsolateral prefrontal cortex (dlPFC) than do of healthy controls (HCs). Disease-specific neural patterns were also found, with prominent hypoactivation in parahippocampal-striatum network for AD, hyperactivation in dopamine-projection striatum network for ADHD and decreased activity in dorsal anterior cingulate cortex and dlPFC for obesity. This study provided robust evidence to reveal the neural substrates of trans-disease process, as well further promoted the triple brain network model in favor of the theoretical developments of these neuropsychiatric disorders.
Persistent Identifierhttp://hdl.handle.net/10722/330705
ISSN
2023 Impact Factor: 3.7
2023 SCImago Journal Rankings: 1.553
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChen, Zhiyi-
dc.contributor.authorBecker, Benjamin-
dc.contributor.authorQin, Pengmin-
dc.contributor.authorLei, Wei-
dc.contributor.authorChen, Jing-
dc.contributor.authorLiu, Peiwei-
dc.contributor.authorLin, Tian-
dc.contributor.authorZhang, Chenyan-
dc.contributor.authorZhang, Rong-
dc.contributor.authorWang, Mengmeng-
dc.contributor.authorXu, Ting-
dc.contributor.authorYang, Yaqi-
dc.contributor.authorFeng, Pan-
dc.contributor.authorFeng, Tingyong-
dc.date.accessioned2023-09-05T12:13:26Z-
dc.date.available2023-09-05T12:13:26Z-
dc.date.issued2021-
dc.identifier.citationJournal of Psychiatric Research, 2021, v. 139, p. 62-70-
dc.identifier.issn0022-3956-
dc.identifier.urihttp://hdl.handle.net/10722/330705-
dc.description.abstractDelay discounting reflects a devaluation of delayed long-term benefits but pursuing immediate rewards. Higher discounting rates (h-DR) are found ubiquitous in many diseases and unhealthy conditions, particularly in addiction disorder (AD), attention-deficit/hyperactivity disorder (ADHD), and obesity. Thus, h-DR was considered to be a common benchmark across many diseases facilitating to understand one disease to relevant others, which was called trans-disease process. However, the common and specific neural biomarkers associated with this process has not yet been studied well. We performed a voxel-wise task-related neuroimaging meta-analysis to clarify the neural pattern of trans-disease process across AD, ADHD and obesity. We recruited 19 eligible papers, including 9 AD papers (154 patients), 6 ADHD papers (106 patients) and 4 obesity studies (94 patients). Neuroimaging meta-analysis demonstrated the presence of neural biomarkers of trans-disease process: these patients showed inadequate brain response in caudate, ventromedial and dorsolateral prefrontal cortex (dlPFC) than do of healthy controls (HCs). Disease-specific neural patterns were also found, with prominent hypoactivation in parahippocampal-striatum network for AD, hyperactivation in dopamine-projection striatum network for ADHD and decreased activity in dorsal anterior cingulate cortex and dlPFC for obesity. This study provided robust evidence to reveal the neural substrates of trans-disease process, as well further promoted the triple brain network model in favor of the theoretical developments of these neuropsychiatric disorders.-
dc.languageeng-
dc.relation.ispartofJournal of Psychiatric Research-
dc.subjectADHD-
dc.subjectMeta-analysis-
dc.subjectNeuroImaging-
dc.subjectTrans-disease process-
dc.subjectTriple network system-
dc.titleNeural networks during delay discounting as trans-disease marker: A meta-analytical review-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jpsychires.2021.05.008-
dc.identifier.pmid34044265-
dc.identifier.scopuseid_2-s2.0-85106600964-
dc.identifier.volume139-
dc.identifier.spage62-
dc.identifier.epage70-
dc.identifier.eissn1879-1379-
dc.identifier.isiWOS:000659230100009-

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