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Article: Comparison of COVID-19 with influenza A in the ICU: a territory-wide, retrospective, propensity matched cohort on mortality and length of stay

TitleComparison of COVID-19 with influenza A in the ICU: a territory-wide, retrospective, propensity matched cohort on mortality and length of stay
Authors
KeywordsAdult intensive & critical care
COVID-19
Respiratory infections
Issue Date10-Jul-2023
PublisherBMJ Publishing Group
Citation
BMJ Open, 2023, v. 13, n. 7 How to Cite?
Abstract

Objectives Direct comparisons between COVID-19 and influenza A in the critical care setting are limited. The objective of this study was to compare their outcomes and identify risk factors for hospital mortality. Design and setting This was a territory-wide, retrospective study on all adult (≥18 years old) patients admitted to public hospital intensive care units in Hong Kong. We compared COVID-19 patients admitted between 27 January 2020 and 26 January 2021 with a propensity-matched historical cohort of influenza A patients admitted between 27 January 2015 and 26 January 2020. We reported outcomes of hospital mortality and time to death or discharge. Multivariate analysis using Poisson regression and relative risk (RR) was used to identify risk factors for hospital mortality. Results After propensity matching, 373 COVID-19 and 373 influenza A patients were evenly matched for baseline characteristics. COVID-19 patients had higher unadjusted hospital mortality than influenza A patients (17.5% vs 7.5%, p<0.001). The Acute Physiology and Chronic Health Evaluation IV (APACHE IV) adjusted standardised mortality ratio was also higher for COVID-19 than influenza A patients ((0.79 (95% CI 0.61 to 1.00) vs 0.42 (95% CI 0.28 to 0.60)), p[removed]


Persistent Identifierhttp://hdl.handle.net/10722/330947
ISSN
2023 Impact Factor: 2.4
2023 SCImago Journal Rankings: 0.971
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChu, RBH-
dc.contributor.authorZhao, S-
dc.contributor.authorZhang, JZ-
dc.contributor.authorChan, KCK-
dc.contributor.authorNg PY-
dc.contributor.authorChan, C-
dc.contributor.authorFong, KM-
dc.contributor.authorAu, SY-
dc.contributor.authorYeung, AWT-
dc.contributor.authorChan, JKH-
dc.contributor.authorTsang, HH-
dc.contributor.authorLaw KI-
dc.contributor.authorChow, FL-
dc.contributor.authorLam KN-
dc.contributor.authorChan, KM-
dc.contributor.authorDharmangadan, M-
dc.contributor.authorWong, WT-
dc.contributor.authorJoynt, GM-
dc.contributor.authorWang, MH-
dc.contributor.authorLing, L-
dc.date.accessioned2023-09-21T06:51:23Z-
dc.date.available2023-09-21T06:51:23Z-
dc.date.issued2023-07-10-
dc.identifier.citationBMJ Open, 2023, v. 13, n. 7-
dc.identifier.issn2044-6055-
dc.identifier.urihttp://hdl.handle.net/10722/330947-
dc.description.abstract<p> Objectives Direct comparisons between COVID-19 and influenza A in the critical care setting are limited. The objective of this study was to compare their outcomes and identify risk factors for hospital mortality. Design and setting This was a territory-wide, retrospective study on all adult (≥18 years old) patients admitted to public hospital intensive care units in Hong Kong. We compared COVID-19 patients admitted between 27 January 2020 and 26 January 2021 with a propensity-matched historical cohort of influenza A patients admitted between 27 January 2015 and 26 January 2020. We reported outcomes of hospital mortality and time to death or discharge. Multivariate analysis using Poisson regression and relative risk (RR) was used to identify risk factors for hospital mortality. Results After propensity matching, 373 COVID-19 and 373 influenza A patients were evenly matched for baseline characteristics. COVID-19 patients had higher unadjusted hospital mortality than influenza A patients (17.5% vs 7.5%, p<0.001). The Acute Physiology and Chronic Health Evaluation IV (APACHE IV) adjusted standardised mortality ratio was also higher for COVID-19 than influenza A patients ((0.79 (95% CI 0.61 to 1.00) vs 0.42 (95% CI 0.28 to 0.60)), p[removed] <br></p>-
dc.languageeng-
dc.publisherBMJ Publishing Group-
dc.relation.ispartofBMJ Open-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectAdult intensive & critical care-
dc.subjectCOVID-19-
dc.subjectRespiratory infections-
dc.titleComparison of COVID-19 with influenza A in the ICU: a territory-wide, retrospective, propensity matched cohort on mortality and length of stay-
dc.typeArticle-
dc.identifier.doi10.1136/bmjopen-2022-067101-
dc.identifier.scopuseid_2-s2.0-85164298794-
dc.identifier.volume13-
dc.identifier.issue7-
dc.identifier.eissn2044-6055-
dc.identifier.isiWOS:001034612700041-
dc.identifier.issnl2044-6055-

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