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Article: The Resolution Rate of Pulmonary Embolism on CT Pulmonary Angiography: a Prospective Study
Title | The Resolution Rate of Pulmonary Embolism on CT Pulmonary Angiography: a Prospective Study |
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Authors | |
Issue Date | 30-Oct-2022 |
Citation | EUROPEAN JOURNAL OF RADIOLOGY, 2022, v. 155 How to Cite? |
Abstract | PurposeTo prospectively assess the rate of clot resolution from CT pulmonary angiography (CTPA) in patients with acute pulmonary embolism (PE). Materials and MethodsThis prospective cohort study included 290 patients (136 men, 154 women; mean age, 51.9 years) with acute PE. All patients had a CTPA at the presentation and had at least one follow-up within 6 months (mean 72.7 days). Sixty-four percent of patients had follow-up scans for research purposes within a pre-determined period (between 28 and 184 days; mean, 78.27 days) and 36 % had (between 2 and 184 days; mean, 62.78 days) for a clinical indication. The volume of each clot was measured using a semi-automated quantification program. The resolution rate was evaluated by interval-censored analysis. ResultsThe overall estimated probability of complete resolution was 42 % at 7 days, 56 % at 10 days, and 71 % at 45 days. Achieving complete resolution was significantly faster in patients with peripheral clots (HR: 1.78; CI: 1.05–3.03, p = 0.032) but slower in patients with consolidation and history of venous thromboembolism (VTE), (HR: 0.37; CI: 0.18–0.79, p = 0.01 and HR: 0.57; CI: 0.35–0.91, p = 0.019, respectively). Although the patients with cancer showed a faster resolution rate (HR: 1.67; CI: 1.05–2.68, p = 0.032), the mortality rate was significantly higher than non-cancer patients. ConclusionThe resolution rate of clot burden in acute PE was associated with patients' clinical presentation variables and CTPA imaging biomarkers. This information may be incorporated into designing a prediction rule and determining the appropriate duration of anticoagulation therapy in patients with acute PE. |
Persistent Identifier | http://hdl.handle.net/10722/331047 |
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ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Ak, M | - |
dc.contributor.author | Gumus, S | - |
dc.contributor.author | Aghayev, A | - |
dc.contributor.author | Chang, C | - |
dc.contributor.author | Fu, B | - |
dc.contributor.author | Roberts, MS | - |
dc.contributor.author | Woodard, PK | - |
dc.contributor.author | Bae, KT | - |
dc.date.accessioned | 2023-09-21T06:52:19Z | - |
dc.date.available | 2023-09-21T06:52:19Z | - |
dc.date.issued | 2022-10-30 | - |
dc.identifier.citation | EUROPEAN JOURNAL OF RADIOLOGY, 2022, v. 155 | - |
dc.identifier.issn | 1111-0041 | - |
dc.identifier.uri | http://hdl.handle.net/10722/331047 | - |
dc.description.abstract | <h3>Purpose</h3><p>To prospectively assess the rate of clot resolution from <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/computed-tomography" title="Learn more about CT from ScienceDirect's AI-generated Topic Pages">CT</a> <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/pulmonary-angiography" title="Learn more about pulmonary angiography from ScienceDirect's AI-generated Topic Pages">pulmonary angiography</a> (CTPA) in <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/patient" title="Learn more about patients from ScienceDirect's AI-generated Topic Pages">patients</a> with <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/acute-pulmonary-embolism" title="Learn more about acute pulmonary embolism from ScienceDirect's AI-generated Topic Pages">acute pulmonary embolism</a> (PE).</p><h3>Materials and Methods</h3><p>This <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/prospective-cohort-study" title="Learn more about prospective cohort study from ScienceDirect's AI-generated Topic Pages">prospective cohort study</a> included 290 <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/patient" title="Learn more about patients from ScienceDirect's AI-generated Topic Pages">patients</a> (136 men, 154 women; mean age, 51.9 years) with acute PE. All patients had a CTPA at the presentation and had at least one follow-up within 6 months (mean 72.7 days). Sixty-four percent of patients had follow-up scans for research purposes within a pre-determined period (between 28 and 184 days; mean, 78.27 days) and 36 % had (between 2 and 184 days; mean, 62.78 days) for a clinical indication. The volume of each clot was measured using a semi-automated quantification program. The resolution rate was evaluated by interval-censored analysis.</p><h3>Results</h3><p>The overall estimated probability of complete resolution was 42 % at 7 days, 56 % <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/dihydrotachysterol" title="Learn more about at 10 from ScienceDirect's AI-generated Topic Pages">at 10</a> days, and 71 % at 45 days. Achieving complete resolution was significantly faster <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/inpatient" title="Learn more about in patients from ScienceDirect's AI-generated Topic Pages">in patients</a> with peripheral clots (HR: 1.78; CI: 1.05–3.03, p = 0.032) but slower <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/inpatient" title="Learn more about in patients from ScienceDirect's AI-generated Topic Pages">in patients</a> with consolidation and history of <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/venous-thromboembolism" title="Learn more about venous thromboembolism from ScienceDirect's AI-generated Topic Pages">venous thromboembolism</a> (VTE), (HR: 0.37; CI: 0.18–0.79, p = 0.01 and HR: 0.57; CI: 0.35–0.91, p = 0.019, respectively). Although the patients with cancer showed a faster resolution rate (HR: 1.67; CI: 1.05–2.68, p = 0.032), the mortality rate was significantly higher than non-cancer patients.</p><h3>Conclusion</h3><p>The resolution rate of clot burden in acute PE was associated with patients' clinical presentation variables and CTPA imaging biomarkers. This information may be incorporated into designing a prediction rule and determining the appropriate duration of <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/anticoagulant-therapy" title="Learn more about anticoagulation therapy from ScienceDirect's AI-generated Topic Pages">anticoagulation therapy</a> in patients with acute PE.</p> | - |
dc.language | eng | - |
dc.relation.ispartof | EUROPEAN JOURNAL OF RADIOLOGY | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.title | The Resolution Rate of Pulmonary Embolism on CT Pulmonary Angiography: a Prospective Study | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.ejrad.2022.110466 | - |
dc.identifier.scopus | eid_2-s2.0-85136180533 | - |
dc.identifier.volume | 155 | - |
dc.identifier.isi | WOS:000862837700010 | - |